Search results for " GABA"
showing 7 items of 127 documents
GABA and its receptors in the enteric nervous system of the gastrointestinal tract.
2009
Distribution and Function of Gap Junction Coupling in Cortical GABAergic Neurons.
2013
Although gap junctions have been observed in GABAergic interneurons of several brain regions, this chapter focuses on the distribution and functions of gap junctions and connexins in inhibitory interneurons of the cerebral cortex and hippocampus. Evidence for interconnections mediated by electrical synapses is reported for at least eight cerebral cortex interneuron types, classified on the basis of morphology, electrophysiology and molecular markers. The main differences in the organization of these interneuronal networks are summarized in terms of homologous and heterologous electrical coupling and mutual chemical inhibition. The role of connexin36 (Cx36) in forming neuronal electrical syn…
?-Carboline binding indicates the presence of benzodiazepine receptor subclasses in the bovine central nervous system
1982
Receptor binding studies were performed with tritiated propyl β-carboline-3-carboxylate ([3H]PrCC), tritiated ethyl β-carboline-3-carboxylate ([3H]ECC), and tritiated flunitrazepam ([3H]FNT) in membrane preparations from different regions of the bovine brain and retina. Specific binding in all regions investigated was associated with benzodiazepine receptor sites. However, not all benzodiazepine receptor sites. However, not all benzodiazepine receptors in the regions investigated as determined by the specific binding of tritiated flunitrazepam ([3H]FNT) are available for [3H]PrCC suggesting that specific [3H]PrCC binding labels only one subclass or subpopulation of the benzodiazepine recept…
Effects of ovariectomy and steroid replacement on GABAA receptor binding in female rat brain.
1991
Abstract The specific binding of tritiated muscimol to γ-aminobutyric acid (GABA) receptor sites was studied in distinct brain areas of female rats during different endocrine states. In diestrous rats with intact ovaries the highest receptor densities were found in the cortex (10.24 pmol/mg protein) and the lowest concentrations in the mediobasal hypothalamus (3.29 pmol/mg protein). Four weeks after removal of the ovaries, the number of binding sites was enhanced up to 2.4-fold in all brain areas investigated: the preoptic brain area, mediobasal hypothalamus, corticomedial amygdala, and cerebral cortex. The affinity of the binding sites remained unchanged. Substitution of estradiol and prog…
(A,B) In vivo GCaMP6f signals recorded in layers M1, M5 and M9/10 of Mi1 (A) and Tm3 (B) neurons, before (blue, green) and after (gray, red) applicat…
2019
Sensory systems sequentially extract increasingly complex features. ON and OFF pathways, for example, encode increases or decreases of a stimulus from a common input. This ON/OFF pathway split is thought to occur at individual synaptic connections through a sign-inverting synapse in one of the pathways. Here, we show that ON selectivity is a multisynaptic process in the Drosophila visual system. A pharmacogenetics approach demonstrates that both glutamatergic inhibition through GluClα and GABAergic inhibition through Rdl mediate ON responses. Although neurons postsynaptic to the glutamatergic ON pathway input L1 lose all responses in GluClα mutants, they are resistant to a cell-type-specifi…
Zemes gabala telpiskās norobežotības problemātika.
2019
Bakalaura darba “Zemes gabala telpiskās norobežotības problemātika” mērķis ir izpētīt un analizēt problēmas, kas rodas zemes gabala robežu noteikšanas un jau esošo robežu pārmērīšanas procesā, lai izprastu, ar kādām normatīvā regulējuma problēmām var saskarties tiesību piemērotāji, konstatējot, ka konkrētā zemes gabala robežas neatbilst to vēsturiskajam plānam vai ir nepareizi noteiktas dabā. Pēc darba autora domām darba aktualitāte ir saistīta ar to, ka Latvijas Republikas normatīvajos aktos ir vairākas problēmas, kas nepārprotami ietekmē zemes gabala telpisko norobežotību un ar to radušos robežstrīdu atrisināšanu, kā rezultātā personām ir liegta iespēja panākt savu īpašuma tiesību saprātī…
Daudzdzīvokļu dzīvojamo ēku un zemes īpašnieku tiesisko attiecību regulējums likumiskās piespiedu nomas lietās.
2018
Maģistra darba mērķis ir noskaidrot, vai tiesību normu gramatiskais formulējums daudzdzīvokļu dzīvojamo ēku un zemes īpašnieku starpā rada lielākos strīdus, neskaidrības un tiesvedības. Lai sasniegtu maģistra darba mērķi, tika veikta padziļināta juridiskās literatūras, normatīvo aktu, nacionālo, ārvalstu un pārnacionālo tiesas prakses, kā arī iestāžu lēmumu, likumprojektu anotāciju un Saeimas stenogrammu izpēte. Darbā tika izvērtēts piespiedu nomas tiesisko attiecību subjektu tiesiskais regulējums un savstarpējo strīdu problemātika. Maģistra darbā uzmanība tika pievērsta tiesību normu attīstības gaitai un pastāvošai tiesu praksei dalītajos īpašumos pilsētās, tieši starp zemes īpašniekiem no…