Search results for " Gastrointestinal Tract"

showing 10 items of 22 documents

Sequential boost in neoadjuvant irradiation for T3N0-1 rectal cancer: long-term results from a single-center experience.

2016

Purpose To evaluate the influence of radiation dose on tumor regression grade (TRG) and sphincter preservation rate in a series of cT3N0-1 rectal cancer patients treated with neoadjuvant chemoradiotherapy (CT-RT) with or without a sequential radiation boost. Materials and methods Between May 2002 and September 2013, 116 cases were eligible for retrospective evaluation. Radiotherapy was delivered for a total dose of 45 Gy (no boost arm) or 50.4 Gy (boost arm). TRG was evaluated with the Dworak scale. Results Median follow-up was 62 months (range, 12-138 months). The 5-year overall survival and local control rates were 72% and 93%, respectively. Fifty-five patients (47%) were treated with a s…

MaleCancer ResearchTime FactorsTumor downsizingColorectal cancermedicine.medical_treatmentAnal CanalKaplan-Meier EstimateSingle Center030218 nuclear medicine & medical imaging0302 clinical medicineAdjuvantNeoadjuvant therapyDigestive System Surgical ProceduresTumor Regression GradeIleostomyMedicine (all)Colorectal cancer; Radiation therapy; Tumor downsizing; Adenocarcinoma; Adult; Aged; Anal Canal; Antineoplastic Agents; Capecitabine; Chemoradiotherapy; Digestive System Surgical Procedures; Female; Fluorouracil; Follow-Up Studies; Gastrointestinal Tract; Humans; Ileostomy; Kaplan-Meier Estimate; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Organ Sparing Treatments; Radiotherapy Dosage; Radiotherapy Adjuvant; Rectal Neoplasms; Retrospective Studies; Time Factors; Treatment Outcome; Urogenital System; Medicine (all); Oncology; Cancer ResearchRadiotherapy DosageGeneral MedicineChemoradiotherapyMiddle AgedNeoadjuvant TherapyRadiation therapyTreatment OutcomeOncology030220 oncology & carcinogenesisFemaleRadiologyFluorouracilmedicine.drugAdultmedicine.medical_specialtyUrogenital SystemAntineoplastic AgentsAdenocarcinomaCapecitabine03 medical and health sciencesmedicineHumansCapecitabineAgedNeoplasm StagingRetrospective StudiesRadiotherapybusiness.industryRectal Neoplasmsmedicine.diseaseColorectal cancerRadiation therapyGastrointestinal TractConcomitantRadiotherapy AdjuvantbusinessOrgan Sparing TreatmentsChemoradiotherapyFollow-Up StudiesTumori
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Functional consequences of microbial shifts in the human gastrointestinal tract linked to antibiotic treatment and obesity

2013

The microbiomes in the gastrointestinal tract (GIT) of individuals receiving antibiotics and those in obese subjects undergo compositional shifts, the metabolic effects and linkages of which are not clearly understood. Herein, we set to gain insight into these effects, particularly with regard to carbohydrate metabolism, and to contribute to unravel the underlying mechanisms and consequences for health conditions. We measured the activity level of GIT carbohydrate-active enzymes toward 23 distinct sugars in adults patients (n = 2) receiving 14-d β-lactam therapy and in obese (n = 7) and lean (n = 5) adolescents. We observed that both 14 d antibiotic-treated and obese subjects showed higher …

MaleobesityAnabolismAntibioticsBody Mass Indexmetabolic reconstructionantibiotic therapySystems and Synthetic Biology2. Zero hungerSysteem en Synthetische Biologie0303 health sciencesGastrointestinal tractMicrobiotaHuman gastrointestinal tractGastroenterologyBiotaAnti-Bacterial Agents3. Good healthInfectious Diseasesmedicine.anatomical_structureglycosidaseCarbohydrate MetabolismFemaleResearch PaperAdultMicrobiology (medical)medicine.medical_specialtyAdolescentmedicine.drug_classCarbohydrate metabolismBiologyMicrobiology03 medical and health sciencesInsulin resistanceInternal medicinemedicineHumansMicrobiomeObesityVLAGAged030304 developmental biologyMetabolic reconstruction030306 microbiologyAntibiotic therapymedicine.diseaseObesityGlycosidaseGastrointestinal TractDistal gutEndocrinologyHyperglycemiaInsulin Resistancedistal gut
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Body mass index and complications following major gastrointestinal surgery

2018

Aim Previous studies reported conflicting evidence on the effects of obesity on outcomes after gastrointestinal surgery. The aims of this study were to explore the relationship of obesity with major postoperative complications in an international cohort and to present a meta-analysis of all available prospective data.Methods This prospective, multicentre study included adults undergoing both elective and emergency gastrointestinal resection, reversal of stoma or formation of stoma. The primary end-point was 30-day major complications (Clavien-Dindo Grades III-V). A systematic search was undertaken for studies assessing the relationship between obesity and major complications after gastroint…

MaleobesityMultivariate analysisGastrointestinal DiseasesIMPACTSettore MED/18 - CHIRURGIA GENERALEBody mass index; Body weight; Digestive tract; Gastrointestinal tract; Obesity; Postoperative complications; Gastroenterologydigestive tractTumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14]0302 clinical medicineGastrointestinal tractRisk FactorsMedicineProspective StudiesProspective cohort studyBody mass indexBody mass index; Body weight; Digestive tract; Gastrointestinal tract; Obesity; Postoperative complications; Aged; Europe; Female; Gastrointestinal Diseases; Gastrointestinal Neoplasms; Humans; Male; Middle Aged; Obesity; Postoperative Complications; Prospective Studies; Risk Factors; Body Mass IndexGastrointestinal NeoplasmsOUTCOMESPostoperative complications; body mass index; body weight; digestive tract; gastrointestinal tract; obesityGastroenterologyMiddle AgedBody mass index; Body weight; Digestive tract; Gastrointestinal tract; Obesity; Postoperative complicationsEurope030220 oncology & carcinogenesisMeta-analysisUrological cancers Radboud Institute for Health Sciences [Radboudumc 15]CohortFemale030211 gastroenterology & hepatologyCohort studymedicine.medical_specialtybody mass indexMalignancyNO03 medical and health sciencesPostoperative complicationsbody weightSDG 3 - Good Health and Well-beingHumansDigestive tractObesityAgedbusiness.industrypostoperative complications; obesity; digestive tract; gastrointestinal tract; body mass index; body weightMORTALITYBody weightmedicine.diseaseObesitySettore MED/18SurgeryPostoperative complicationPostoperative Complications Obesity Digestive Tract Gastrointestinal Tract Body Mass Index Body Weight.gastrointestinal tractbusinessBody mass indexColorectal Disease
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MALIGNANT TUMOR-LIKE GAASTRIC LESION DUE TO CANDIDA ALBICANS IN A DIABETIC PATIENT TREATED WITH CYCLOSPORIN: A CASE REPORT AND REVIEW OF THE LITERATU…

2012

The gastrointestinal tract of healthy individuals is colonized by hundreds of saprophytes and mycetes, especially the Candida species, are habitual ones. Under certain conditions, the fungal flora may overgrow, resulting in lesions of the digestive mucosa which, rarely, can have a local diffusion and/or spread to the lympho-hematogenous system. Mycotic infections of the stomach can sometimes look like benign gastric ulcers. Here, we present the case report of a woman, aged 64, who presented with type II diabetes mellitus and psoriasis, on chronic treatment with cyclosporin A and with endoscopic evidence of an ulcerated, vegetating gastric lesion secondary to Candida albicans infection. Alth…

Pathologymedicine.medical_specialtyAntifungal AgentsSettore MED/09 - Medicina InternaSettore MED/08 - Anatomia PatologicaMalignancyGastroenterologyGeneral Biochemistry Genetics and Molecular BiologyCyclosporin aDiabetes mellitusInternal medicinePsoriasisCandida albicansCandidiasis Mycotic infection of the gastrointestinal tract submucosal tumorHumansMedicineStomach UlcerCandida albicansGastrointestinal tractHematologybiologybusiness.industryStomachCandidiasisGeneral MedicineMiddle Agedbiology.organism_classificationmedicine.diseaseSettore MED/18 - Chirurgia Generalemedicine.anatomical_structureDiabetes Mellitus Type 2CyclosporineFemaleItraconazolebusiness
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Identification of Rothia Bacteria as Gluten-Degrading Natural Colonizers of the Upper Gastro-Intestinal Tract

2011

Background Gluten proteins, prominent constituents of barley, wheat and rye, cause celiac disease in genetically predisposed subjects. Gluten is notoriously difficult to digest by mammalian proteolytic enzymes and the protease-resistant domains contain multiple immunogenic epitopes. The aim of this study was to identify novel sources of gluten-digesting microbial enzymes from the upper gastro-intestinal tract with the potential to neutralize gluten epitopes. Methodology/Principal Findings Oral microorganisms with gluten-degrading capacity were obtained by a selective plating strategy using gluten agar. Microbial speciations were carried out by 16S rDNA gene sequencing. Enzyme activities wer…

ProteomicsApplied Microbiologylcsh:MedicineBiochemistryGliadinEpitopeSubstrate SpecificityUpper Gastrointestinal Tractlcsh:ScienceBifidobacterium2. Zero hungerchemistry.chemical_classification0303 health sciencesAniline CompoundsMultidisciplinarymedicine.diagnostic_testbiologyHydrolysisProteolytic enzymesfood and beveragesHydrogen-Ion ConcentrationEnzymes3. Good healthSolutionsBiochemistryMedical MicrobiologyMedicineSmall IntestineResearch ArticleProteasesGlutensProteolysisMolecular Sequence DataDental PlaqueGastroenterology and HepatologyMicrobiologydigestive systemMicrobiology03 medical and health sciencesAntigenmedicineHumansAmino Acid SequenceSalivaBiology030304 developmental biologyBinding Sites030306 microbiologylcsh:Rnutritional and metabolic diseasesbiology.organism_classificationGlutenPeptide Fragmentsdigestive system diseasesMolecular WeightCeliac DiseasechemistryProteolysisbiology.proteinlcsh:QGliadinMicrococcaceaePLoS ONE
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REPORT OF A CASE OF MALIGNANT TUMOR-LIKE GASTRIC LESION BY CANDIDA IN A DIABETIC TREATED WITH CYCLOSPORINE FOR PSORIASIS AND REVIEW OF THE LITERATURE

2011

Mycotic infection of the alimentary canal are rare and usually involve the upper digestive tract. Mycetes, especially of Candida family, are habitual saprophytes in the digestive tract of healthy individuals. Under certain conditions, fungal flora may overgrowth, resulting in lesions of the digestive mucosa, which, rarely, might evolve to local diffusion and/or systemic lympho-hematogenous spreading. In the stomach, sometimes, mycotic infections may appear like benign gastric ulcers. we described a case of woman, aged 64, affected by psoriasis, in chronic treatment with cyclosporine and type 2 diabetes mellitus, a well-known immunosoppressive condition, with endoscopic evidence of ulcerated…

Settore MED/18 - Chirurgia GeneraleSettore MED/12 - GastroenterologiaSettore MED/09 - Medicina InternaCandidiasis mycotic infection of the gastrointestinal tract submucosal tumor.Settore MED/08 - Anatomia Patologica
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MSCT in GIST patients with hepatic metastases treated with new generation tyrosinkinase inhibitors: comparison between density and dimension

2013

Purpose Methods and Materials Results Conclusion References Personal Information

StagingOncologyGastrointestinal tractAbdomenMonoclonal antibodiesMetastasesContrast agent-intravenousOncology Abdomen Gastrointestinal tract CT Contrast agentintravenous Staging Cancer Metastases Monoclonal antibodiesSettore MED/36 - Diagnostica Per Immagini E RadioterapiaCTCancer
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Evaluation of pelvic floor dysfunctions with Defeco-MR: an accurate MR protocol and a radiological template.

2016

Learning objectives Background Findings and procedure details Conclusion Personal information References

genetic structuresGastrointestinal tractPelvis Anatomy Gastrointestinal tract MR Defecography Pelvic floor dysfunctioneducationAnatomyMRPelvisDefecographyPelvic floor dysfunction
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DEFECTS IN DOPAMINERGIC PATHWAY AFFECT CONTRACTILITY OF COLON FROM HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE (HPRT) KNOCKOUT MICE.

2010

Lesch-Nyhan disease is an X-linked neurobehavioral and metabolic disorder caused by lack of hypoxanthine phosphoribosyltransferase (HPRT), a housekeeping enzyme responsible for recycling purines. The mechanisms underlying the neuropathology are not well understood, but the main neurochemical defect, in central nervous system, is linked to a dysfunction of dopaminergic pathway. In the enteric nervous system the dopaminergic nerves are a subset neurons of regulating gut motility, thus we investigated possible changes in colonic motility of HPRT ¯mice related to the dopaminergic control. We evaluated, in vitro, the mechanical activity of circular muscle strips from wild type and HPRT – mouse c…

hprt dopamine gastrointestinal tract
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Impact of Oat-Based Products on Human Gastrointestinal Tract

2015

Abstract Oat is rich in valuable nutrients. In comparison to other cereals, oat contains more total proteins, carbohydrate, fat, non-starch fibre, as well as unique antioxidants (one of them - avenanthramides), vitamins, and minerals. One of the most often studied components of oats is β-glucan - a type of soluble dietary fibre located throughout the starch endosperm, but with highest concentration in the bran. Many studies have shown the beneficial health effects of oat β-glucan as a soluble dietary fibre. Until now, most of the studies on this nutrient have been conducted in the cardiovascular and diabetology field. This article aimed to review the literature on studies that investigated …

irritable bowel syndromemedicine.medical_specialtyMultidisciplinaryBranColorectal canceravena sativaScienceQHuman gastrointestinal tractfood and beveragesgastrointestinal microfloracolorectal cancermedicine.diseaseInflammatory bowel diseaseUlcerative colitisGastroenterologymedicine.anatomical_structureNutrientinflammatory bowel diseaseInternal medicinemedicineIn patientIrritable bowel syndromeProceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.
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