Search results for " Gian"

Expression of Interleukin-32 in the Inflamed Arteries of Patients With Giant Cell Arteritis

2011

Objective Giant cell (temporal) arteritis (GCA) is a vasculitis that mainly affects the large and medium arteries, especially the branches of the proximal aorta. Interleukin-32 (IL-32) is a recently described Th1 proinflammatory cytokine, and is mainly induced by interferon-γ (IFNγ), IL-1β, and tumor necrosis factor α (TNFα). This study was undertaken to investigate the expression and tissue distribution of IL-32 in artery biopsy specimens from patients with GCA. Methods Quantitative gene expression analysis of IL-32, IL-1β, TNFα, IFNγ, IL-6, and IL-27 was performed in artery biopsy specimens obtained from 18 patients with GCA and 15 controls. Immunohistochemistry analysis was performed to …

Th1 and Th17 lymphocytes expressing CD161 are implicated in giant cell arteritis and polymyalgia rheumatica pathogenesis.

2012

International audience; OBJECTIVE: Giant cell arteritis (GCA) is the most frequently occurring vasculitis in elderly individuals, and its pathogenesis is not fully understood. The objective of this study was to decipher the role of the major CD4+ T cell subsets in GCA and its rheumatologic form, polymyalgia rheumatica (PMR). METHODS: A prospective study of the phenotype and the function of major CD4+ T cell subsets (Th1, Th17, and Treg cells) was performed in 34 untreated patients with GCA or PMR, in comparison with 31 healthy control subjects and with the 27 treated patients who remained after the 7 others withdrew. RESULTS: Compared with control subjects, patients with GCA and patients wi…

IL-33 is overexpressed in the inflamed arteries of patients with giant cell arteritis.

2013

OBJECTIVE: To study the expression of interleukin (IL)-33 and to evaluate its relationship with macrophage polarisation in artery biopsy specimens from patients with giant cell arteritis (GCA). METHODS: IL-33, ST2, p-STAT-6 and perivascular IL-1 receptor-associated kinase 1 (p-IRAK1) tissue distribution was evaluated by immunohistochemistry. Inducible nitric oxide synthase and CD163 were also used by immunohistochemistry to evaluate the M1 and M2 polarisation, respectively. Quantitative gene expression analysis of IL-33, T-helper (Th)2-related transcription factor STAT6, Th2 cytokines (IL-4, IL-5, IL-25) and interferon (IFN)-γ was performed in artery biopsy samples obtained from 20 patients…

Osteoclast-like Giant Cell Tumor of the Pancreas With Ductal Adenocarcinoma: Case Report with Novel Data on Histogenesis

2002

Cell fusion as a mechanism for the formation of giant cells (Langhans’ type)

1982

The formation of multinuclear giant cells of the Langhans' type in tubulo-interstitial auto-immune nephritis in the rat has been investigated by means of autoradiography. While in the majority of giant cells all nuclei were radiolabeled, in a few both labeled and unlabeled nuclei were present. This latter finding represents strong evidence in favour of the hypothesis that giant cells do not form by endomitotic processes but rather through fusion of certain precursor cells. According to previous studies this precursor cell population consists mainly of epitheloid cells, i.e. modified monocytes.

Giant unruptured circumflex coronary artery aneurysms presenting as acute coronary syndrome

2020

Ospedale psichiatrico di Sassari

2015

Il testo è relativo all'Ospedale psichiatrico di Sassari, sorto alla fine dell'Ottocento e rimasto in funzione sino al 1998, è stata redatta nell'ambito della ricerca (PRIN 2008), "I complessi manicomiali in Italia tra Otto e Novecento. Atlante del patrimonio storico-architettonico ai fini della conoscenza e della valorizzazione", sviluppata da ricercatori della Seconda Università di Napoli (coordinamento nazionale), dei Politecnici di Milano e Torino, delle Università di Camerino, Palermo, Pisa e Reggio Calabria. La scheda illustra, attraverso i diversi testi e un vasto repertorio iconografico, costituito da disegni, immagini d’epoca e fotografie – sia l’origine sia le trasformazioni dei c…

Lithium in metal-poor red giants

2009

AbstractThe lithium abundance was calculated for five metal-poor red giant stars from Li i doublet at 6707 Å by fitting the observed high-resolution spectra with synthetic spectra. The lithium abundance was found to be low in all stars, logϵ(Li) ≤ 1.8, confirming lithium depletion on the red giant and asymptotic giant branch.

A new species of Ferula (Apiaceae) from Malta

2018

Ferula melitensis, a new species from the Malta Archipelago, is described and illustrated. It belongs to the taxonomic group of F. communis, showing close relationships mainly with F. tunetana, F. arrigonii, F. communis s.str. and F. glauca, from which it differs in several features regarding the stem, leaves (mainly for shape and size of terminal segments), flowers and mericarps; other significant differences regard the ecology and phenology. The investigations, carried out on living plants, herbarium material and literature data, regard the morphological analysis of vegetative and reproductive structures, the anatomy of terminal leaf segments and mericarps, as well as the shape and size o…

Freeze-fracture features of epithelioid cells, multinucleated giant cells, and phagocytic macrophages

1987

The freeze-fracture morphology of epithelioid cells, multinucleated giant cells (Langhans' type), and phagocytic macrophages was investigated. The intensely folded and interdigitating surface membranes of epithelioid cells and multinucleated giant cells displayed no specialized areas of cell contact. The size of the intramembranous particles (IMP) and the fact that the area density of IMPs was higher in the cytoplasmic (P) faces than in the external (E) faces of the cell membranes agreed with observations in other eukaryotic cells. The area densities of the IMPs suggest lower transport rates of molecules across the cell membranes of granuloma cells than of certain epithelial cells. Small pi…