Search results for " Glu"

Identification and expression of the 11β‐steroid hydroxylase from Cochliobolus lunatus in Corynebacterium glutamicum

2019

Hydroxylation of steroids has acquired special relevance for the pharmaceutical industries. Particularly, the 11β-hydroxylation of steroids is a reaction of biotechnological importance currently carried out at industrial scale by the fungus Cochliobolus lunatus. In this work, we have identified the genes encoding the cytochrome CYP103168 and the reductase CPR64795 of C. lunatus responsible for the 11β-hydroxylase activity in this fungus, which is the key step for the preparative synthesis of cortisol in industry. A recombinant Corynebacterium glutamicum strain harbouring a plasmid expressing both genes forming a synthetic bacterial operon was able to 11β-hydroxylate several steroids as subs…

Oral semaglutide and cardiovascular outcomes in patients with type 2 diabetes.

2019

BACKGROUND Establishing cardiovascular safety of new therapies for type 2 diabetes is important. Safety data are available for the subcutaneous form of the glucagon-like peptide-1 receptor agonist semaglutide but are needed for oral semaglutide. METHODS We assessed cardiovascular outcomes of once-daily oral semaglutide in an event-driven, randomized, double-blind, placebo-controlled trial involving patients at high cardiovascular risk (age of ≥50 years with established cardiovascular or chronic kidney disease, or age of ≥60 years with cardiovascular risk factors only). The primary outcome in a time-to-event analysis was the first occurrence of a major adverse cardiovascular event (death fro…

Ossidazione fotocatalitica del glucosio in presenza di TiO2

2014

Organic materials in the wall paintings in Pompei: a case study of Insuladel Centenario

2012

Abstract Background The present research concerns the Roman wall paintings preserved at Insula del Centenario (IX, 8), the important Pompeian block situated in the Regio IX, along Via di Nola. Results The aims of this research are two: to verify the presence of lipidic and proteinaceous material to spread the pigments, and to identify organic matter in painting materials owing to previous restoration works. The samples collected from the wall paintings of different rooms have been investigated by Fourier Transform Infrared Spectroscopy (FT-IR), and Gas Chromatography/ Mass Spectrometry (GC/MS). Conclusions The analytical results show that these Roman wall paintings were realized without the…

The automated pancreas: A review of technologies and clinical practice

2021

Insulin pumps and glucose sensors are effective in improving diabetes therapy and reducing acute complications. The combination of both devices using an algorithm-driven interoperable controller makes automated insulin delivery (AID) systems possible. Many AID systems have been tested in clinical trials and have proven safety and effectiveness. However, currently, none of these systems are available for routine use in children younger than 6 years in Europe. For continued use, both users and prescribers must have sound knowledge of the features of the individual AID systems. Presently, all systems require various user interactions (e.g. meal announcements) because fully automated systems ar…

Combination of Tevatron searches for the standard model Higgs boson in the W+W- decay mode.

2010

11 páginas, 4 figuras, 1 tabla.-- CDF Collaboration: et al.

Factorization of the soft gluon divergence from the dipole picture deep inelastic scattering cross sections at next-to-leading order

2018

We use a factorization scheme analogous to one proposed for single inclusive forward hadron production to factorize the soft gluon divergence present in the deep inelastic scattering cross sections in the dipole picture at next-to-leading order (NLO). We show numerically that in this carefully constructed scheme it is possible to obtain meaningful results for the DIS cross sections at NLO, and so we are able to quantitatively study the recently derived NLO corrections to the DIS cross sections. We find that the NLO corrections can be significant and sensitive to the details of the factorization scheme used for the resummation of the large logarithms into the BK evolution equation. In the ca…

Nuclear gluons at RHIC in a multi-observable approach

2019

We explore the possibility of measuring nuclear gluon distributions at the Relativistic Heavy-Ion Collider (RHIC) with $\sqrt{s}=200 \, {\rm GeV}$ proton-nucleus collisions. In addition to measurements at central rapidity, we consider also observables at forward rapidity, consistent with proposed upgrades to the experimental capabilities of STAR and sPHENIX. The processes we consider consist of Drell-Yan dilepton, dijet, and direct photon-jet production. The Drell-Yan process is found to be an efficient probe of gluons at small momentum fractions. In order to fully utilize the potential of Drell-Yan measurements we demonstrate how the overall normalization uncertainty present in the experim…

Multigluon Correlations and Evidence of Saturation from Dijet Measurements at an Electron-Ion Collider.

2020

We study inclusive and diffractive dijet production in electron-proton and electron-nucleus collisions within the Color Glass Condensate effective field theory. We compute dijet cross sections differentially in both mean dijet transverse momentum $\mathbf{P}$ and recoil momentum $\mathbf{\Delta}$, as well as the anisotropy in the relative angle between $\mathbf{P}$ and $\mathbf{\Delta}$. We use the nonlinear Gaussian approximation to compute multiparticle correlators for general small $x$ kinematics, employing running coupling Balitsky-Kovchegov evolution to determine the dipole amplitude at small $x$. Our results cover a much larger kinematic range than accessible in previous computations …

Modelling the spatial and temporal constrains of the GABAergic influence on neuronal excitability

2021

GABA (γ-amino butyric acid) is an inhibitory neurotransmitter in the adult brain that can mediate depolarizing responses during development or after neuropathological insults. Under which conditions GABAergic membrane depolarizations are sufficient to impose excitatory effects is hard to predict, as shunting inhibition and GABAergic effects on spatiotemporal filtering of excitatory inputs must be considered. To evaluate at which reversal potential a net excitatory effect was imposed by GABA (EGABAThr), we performed a detailed in-silico study using simple neuronal topologies and distinct spatiotemporal relations between GABAergic and glutamatergic inputs. These simulations revealed for GABAe…