Search results for " Heavy"

showing 10 items of 447 documents

Downregulation of myogenic microRNAs in sub-chronic but not in sub-acute model of daunorubicin-induced cardiomyopathy

2016

Cardiac muscle-related microRNAs play important roles in cardiac development and disease by translational silencing of mRNAs, the dominant mechanism of microRNA action. To test whether they could be involved in daunorubicin-associated cardiomyopathy (DACM), we determined expression patterns of myomiRs in two distinct models of DACM. We used 10–12 weeks old male Wistar rats. In the sub-acute model, rats were administered with six doses of daunorubicin (DAU-A, 3 mg/kg, i.p., every 48 h). Rats were sacrificed two days after the last dose. In the sub-chronic model, anaesthetized rats were administered a single dose of daunorubicin (15 mg/kg, i.v., DAU-C). Age-matched controls (CON) receive…

Settore BIO/17 - IstologiaMale0301 basic medicinemedicine.medical_specialtyAnthracyclineCardiomyopathyDaunorubicinClinical BiochemistryCardiomyopathyDown-RegulationMuscle ProteinsAnthracyclineBiology03 medical and health sciencesDownregulation and upregulationInternal medicineGene expressionmedicineAnimalsRats WistarMolecular BiologyNADPH oxidaseNADPH oxidaseDaunorubicinMyosin heavy chain isoformMicroRNACell BiologyGeneral Medicinemedicine.diseaseRatsDisease Models AnimalMicroRNAs030104 developmental biologyEndocrinologybiology.proteinMYH7Gene expressionMYH6Cardiomyopathiesmedicine.drugMolecular and Cellular Biochemistry
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Metilazione del DNA in artrite reumatoide

2005

Lo stato di metilazione del DNA genomico e del gene PTHrP è stato valutato con tecniche molecolari e citogenetiche in artrite reumatoide (AR), patologia autoimmune caratterizzata anche da alta incidenza di linfomi e da ipercalcemia per overespressione del gene PTHrP. La metilazione del DNA, infatti, ha un ruolo critico nello sviluppo delle malattie neoplastiche; il gene PTHrP avendo tre promotori uno dei quali contiene un’isola CpG è un buon candidato per la deregolazione da alterato pattern di metilazione locale. Le indagini sulla metilazione genomica, condotte su DNA estratto da sangue periferico di pazienti e di donatori e amplificato in reazioni di Methylation-Sensitive Arbitrarily Prim…

Settore BIO/18 - Geneticainstead chromosomes of controls were almost uniformly decorated by brilliant grains. Studies on methylation of PTHrP gene promoter 2 performed on five CpG island internal sites using the Methylation-Sensitive Restriction Endonuclease Multiplex (MSREM)-PCR showed that one of the sites nearest the trascription starting point is heavy methylated in a significantly high number of RA patients. Thus RA seems to be characterized by genomewide hypomethylation associated with local hypermethylation like the most part of tumors. This result raises the possibility that susceptibility to lymphomas is related to abnormal DNA methylation levels and suggests the opportunity to evaluate the DNA methylation status in RA patientin fact the demethylating therapies together with diet and life style can act towards an increase of tumor risk. Future studies using a larger number of subjects could confirm these findings.Rheumatoid Arthritis (RA) is a chronic multisystem inflammatory disease characterized by high recurrence of lymphomas as well as hypercalcemia due to PTHrP overexpression. Because of DNA methylation plays a critical role in development of neoplasias we determined in RA patients the global DNA methylation status and local methylation pattern of the CpG island of one of the three promoters of PTHrP gene utilizing molecular and cytogenetic techniques. Investigations performed on DNA from peripheral blood of patients and donors amplified by Methylation-Sensitive Arbitrarily Primed (MeS-AP)-PCR indicated that RA is strongly associated with global DNA hypomethylation. Similarly chromosomal DNA methylation pattern analysis by indirect immunofluorescence technique with anti 5-methylcitosine antibody showed all peripheral lymphocyte metaphases from RA patients with chromosomes weakly fluorescent without discrete grain
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NiO@Ni core shell for electrochemical detection of Hg ions

2018

Heavy metals are considered as one of the most dangerous chemicals for human health. Among heavy metals, mercury is one of the most dangerous one: few ppb of Hg can cause serious damages to brain, heart, lungs and kidney. The Environmental Protection Agency setted the maximum concentration of Hg in water as 2 ppb [1] . Nowadays is very important to develop new and novel sensors for heavy metals that could be cheap, easy to use and for in-situ and real-time analysis and in this context electrochemical sensors are perfect candidates [2] . The more powerful electrochemical tequinique is Square Wave Anodic Strippic Voltammetry (SWASV), a two step techinique were the heavy metals are first depos…

Settore ING-IND/23 - Chimica Fisica ApplicataSquare Wave Anodic Strippic Voltammetry Heavy metals mercury sensors electrochemical detection
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The organic carbon derived from sewage sludge as a key parameter determining the fate of trace metals.

2007

8 pages; International audience; In a sandy agricultural soil of south-west of France, continuously cultivated with maize and amended with sewage-sludge over 20 years, the behavior of three trace metals (Cu, Pb, and Zn) was studied during the sludge applications (1974-1993) and after its cessation (1993-1998). Using the delta13C analysis, the dynamics of different sources of organic matter were followed in order to elucidate the influence of the sludge-derived organic matter on the fate of trace metals in the soil and its particle size fractions. This study revealed that sludge-derived organic matter contributed to the formation of macroaggregates through the binding of preexisting microagg…

Sewage-sludgeHealth Toxicology and Mutagenesis010501 environmental sciencesChemical FractionationMESH : Carbon01 natural sciencesMESH : Soil Pollutants[SDU.STU.GC]Sciences of the Universe [physics]/Earth Sciences/GeochemistryMESH : Particle SizeSoil PollutantsTotal organic carbonchemistry.chemical_classificationCarbon IsotopesParticle-size fractionsSewage04 agricultural and veterinary sciencesGeneral MedicineMESH: Metals HeavyPollutionSoil contamination6. Clean water[ SDE.MCG ] Environmental Sciences/Global ChangesEnvironmental chemistryMESH : Metals HeavyFranceValorisationMESH : Carbon IsotopesMESH: Nitrogen IsotopesMESH : FertilizersEnvironmental Engineering[SDE.MCG]Environmental Sciences/Global Changesd13CAmendment[ SDV.SA.SDS ] Life Sciences [q-bio]/Agricultural sciences/Soil studychemistry.chemical_elementMESH: CarbonZincMESH: Fertilizers[SDV.SA.SDS]Life Sciences [q-bio]/Agricultural sciences/Soil studyMESH: Chemical FractionationTrace metalsMetals HeavyEnvironmental ChemistryOrganic matterMESH: Particle SizeParticle SizeMESH : FranceFertilizersOrganic carbonMESH: Sewage0105 earth and related environmental sciencesMESH : Nitrogen IsotopesMESH: Soil PollutantsNitrogen IsotopesMESH : Chemical FractionationPublic Health Environmental and Occupational HealthEnvironmental engineeringMESH: Carbon IsotopesGeneral ChemistryBiodegradation[ SDU.STU.GC ] Sciences of the Universe [physics]/Earth Sciences/Geochemistry[SDE.ES]Environmental Sciences/Environmental and SocietyCarbonMESH: FrancechemistryMESH : Sewage040103 agronomy & agriculture0401 agriculture forestry and fisheriesSludge[ SDE.ES ] Environmental Sciences/Environmental and Society
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Design, characterization and evaluation of hydroxyethylcellulose based novel regenerable supersorbent for heavy metal ions uptake and competitive ads…

2017

Abstract Hydroxyethylcellulose succinate-Na (HEC-Suc-Na) was designed and evaluated for removal of some heavy metal ions from aqueous solution. Pristine sorbent HEC-Suc-Na was thoroughly characterized by FTIR and solid-state CP/MAS 13C NMR spectroscopy, SEM-EDS and zero point charge analyses. Langmuir isotherm, pseudo second order kinetic and ion exchange models provided best fit to the experimental data of sorption of metal ions. Maximum sorption capacities of supersorbent HEC-Suc-Na for sorption of heavy metal ions from aqueous solution as calculated by Langmuir isotherm model were found to be 1000, 909.09, 666.6, 588 and 500 mg g−1 for Pb(II), Cr(VI), Co(II), Cu(II) and Ni(II), respectiv…

SorbentMetal ions in aqueous solutionInorganic chemistry02 engineering and technology010501 environmental sciences01 natural sciencesBiochemistryWater Purificationsymbols.namesakeStructural BiologyMetals HeavyGalvanic cellFourier transform infrared spectroscopyCelluloseMolecular Biology0105 earth and related environmental sciencesAqueous solutionIon exchangeChemistryTemperatureLangmuir adsorption modelSorptionGeneral MedicineHydrogen-Ion Concentration021001 nanoscience & nanotechnologyKineticsDrug DesignsymbolsAdsorption0210 nano-technologyWater Pollutants ChemicalInternational Journal of Biological Macromolecules
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Interaction of UO2(2+) with ATP in aqueous ionic media.

2005

Interaction of dioxouranium(VI) (uranyl) ion with ATP was studied by ligand/proton and metal/hydroxide displacement technique, at very low ionic strength and at I=0.15 mol L(-1), in aqueous Me4NCl and NaCl solutions, at t=25 degrees C. Measurements were carried out in the pH range 3-8.5, before the formation of precipitate. Computer analysis allowed us to find the quite stable species UO2(ATP)H2(0), UO2(ATP)H-, UO2(ATP)2-, UO2(ATP)2(6-), UO2(ATP)2H2(4-) and UO2(ATP)(OH)3- whose formation constants are (at I=0 mol L(-1)) logbeta(112)=18.21, logbeta(111)=14.70, logbeta(110)=9.14, logbeta(120)=12.84, logbeta(122)=24.82, and logbeta(11-1)=2.09, respectively. Different values were obtained in th…

SpeciationInorganic chemistryIonic mediaBiophysicsIonic bondingLigandsBiochemistryComplexeIonMetalchemistry.chemical_compoundAdenosine TriphosphateMetals HeavySettore CHIM/01 - Chimica AnaliticaAqueous solutionLigandHydrolysisOrganic ChemistryWaterHydrogen-Ion ConcentrationUranylUranium CompoundsDioxouranium(VI)ATPchemistryStability constants of complexesvisual_artDependence on medium of stability constantvisual_art.visual_art_mediumHydroxideBiophysical chemistry
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Multivariate nonparametric estimation of the Pickands dependence function using Bernstein polynomials

2017

Abstract Many applications in risk analysis require the estimation of the dependence among multivariate maxima, especially in environmental sciences. Such dependence can be described by the Pickands dependence function of the underlying extreme-value copula. Here, a nonparametric estimator is constructed as the sample equivalent of a multivariate extension of the madogram. Shape constraints on the family of Pickands dependence functions are taken into account by means of a representation in terms of Bernstein polynomials. The large-sample theory of the estimator is developed and its finite-sample performance is evaluated with a simulation study. The approach is illustrated with a dataset of…

Statistics and ProbabilityFOS: Computer and information sciencesMultivariate statisticsNONPARAMETRIC ESTIMATIONMULTIVARIATE MAX-STABLE DISTRIBUTION01 natural sciencesCopula (probability theory)Methodology (stat.ME)010104 statistics & probabilityStatisticsStatistics::Methodology0101 mathematicsExtreme-value copulaEXTREMAL DEPENDENCEEXTREMEVALUE COPULA[SDU.ENVI]Sciences of the Universe [physics]/Continental interfaces environmentStatistics - MethodologyComputingMilieux_MISCELLANEOUSMathematics[SDU.OCEAN]Sciences of the Universe [physics]/Ocean AtmosphereApplied Mathematics010102 general mathematicsNonparametric statisticsEstimatorExtremal dependenceHEAVY RAINFALLBernstein polynomialBERNSTEIN POLYNOMIALS EXTREMAL DEPENDENCE EXTREMEVALUE COPULA HEAVY RAINFALL NONPARAMETRIC ESTIMATION MULTIVARIATE MAX-STABLE DISTRIBUTION PICKANDS DEPENDENCE FUNCTION13. Climate actionDependence functionStatistics Probability and UncertaintyMaximaSettore SECS-S/01 - StatisticaBERNSTEIN POLYNOMIALSPICKANDS DEPENDENCE FUNCTION
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Piezospectroscopic study of mechanical stress in Al2O3:Cr under swift heavy ion irradiation

2009

Abstract The spatial distribution of mechanical stresses in Al2O3:Cr single crystal irradiated with (1 ÷ 3) MeV/amu Kr, Xe and Bi ions has been studied by using laser confocal scanning microscopy technique. The stress level as a function of the ion penetration depth has been evaluated from depth-resolved photostimulated R-line luminescence spectra exploiting the piezospectroscopic method. As it was found, the stress field generated by swift heavy ion irradiation is composed of stresses with maximal magnitude comparable with the ultimate stress limit of ruby crystals. Experimental data are discussed in the framework of a model considering the Cr3+ atoms as individual piezosensors.

Stress fieldSwift heavy ionMaterials scienceRadiation damageIrradiationAtomic physicsConfocal scanning microscopyCondensed Matter PhysicsPenetration depthInstrumentationSingle crystalSurfaces Coatings and FilmsIonVacuum
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Two-particle azimuthal correlations in photonuclear ultraperipheral Pb+Pb collisions at 5.02 TeV with ATLAS

2021

We thank CERN for the very successful operation of the LHC, as well as the support staff from our institutions without whom ATLAS could not be operated efficiently. We acknowledge the support of ANPCyT, Argentina, YerPhI, Armenia, ARC, Australia, BMWFW and FWF, Austria, ANAS, Azerbaijan, SSTC, Belarus, CNPq and FAPESP, Brazil, NSERC, NRC, and CFI, Canada, CERN and ANID, Chile, CAS, MOST, and NSFC, China, COLCIENCIAS, Colombia, MSMT CR, MPO CR, and VSC CR, Czech Republic, DNRF and DNSRC, Denmark, IN2P3-CNRS and CEA-DRF/IRFU, France, SRNSFG, Georgia, BMBF, HGF, and MPG, Germany, GSRT, Greece, RGC and Hong Kong SAR, China, ISF and Benoziyo Center, Israel, INFN, Italy, MEXT and JSPS, Japan, CNR…

Systemgap [rapidity]heavy ion: scattering:Kjerne- og elementærpartikkelfysikk: 431 [VDP]Performanceangular correlation: long-rangeHadronMonte Carlo method01 natural sciencesHigh Energy Physics - ExperimentSubatomär fysikHigh Energy Physics - Experiment (hep-ex)PpCollisionscorrelation function: two-particleSubatomic Physics[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex]Nuclear Experiment (nucl-ex)Nuclear ExperimentNuclear Experimentcalorimeter: forward spectrometerSettore FIS/01Physicsangular correlation: two-particletwo-particle [correlation function]Large Hadron Collider4. EducationATLAS experimentHeavy-Ion CollisionsMonte Carlo [numerical calculations]ATLASCalorimeterforward spectrometer [calorimeter]CERN LHC Coll:Nuclear and elementary particle physics: 431 [VDP]medicine.anatomical_structureMultiplicityflowPseudorapidityDistributionsLhcnumerical calculations: Monte CarloParticle Physics - Experimentcharged particle: tracks530 PhysicscollectiveFOS: Physical sciencesLHC ATLAS High Energy Physicstransverse momentum[PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex]Relativistic heavy ionscharged particle: multiplicityNuclear physicsmultiplicity [charged particle]scattering [heavy ion]Atlas (anatomy)long-range [angular correlation]0103 physical sciencesmedicineFluctuationsNuclear Physics - Experimentddc:5305020 GeV-cms/nucleonHigh Energy Physicsperipheral010306 general physicshadron hadron: interactioninteraction [hadron hadron]LHC; Particle Physics; Photonuclear interactionstwo-particle [angular correlation]tracks [charged particle]010308 nuclear & particles physicsFísicaDetectorMultiplicity (mathematics)boundary conditionrapidity: gapcorrelationExperimental High Energy Physicsexperimental resultsModelPhysical Review C
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Preparation and characterization of sodium iron titanate ion exchanger and its application in heavy metal removal from waste waters.

2006

Abstract The ion exchange properties of sodium iron titanates, namely, NaFeTiO4, Na2Fe2Ti6O16 and iron-doped sodium nonatitanate were investigated. Conventional solid state and sol–gel methods were used in the synthesis of the sodium iron titanates. Structural characterization of the materials was performed with powder X-ray diffraction (XRD), thermogravimetry (TG), scanning electron microscopy (SEM) equipped with energy dispersive spectrometer (EDS) and with inductively coupled plasma optical emission spectrometry (ICP-OES). Based on TG analyses, the novel iron-doped sodium nonatitanate was proven to be a member of the layered titanate family. The different sodium iron titanates were compa…

TitaniumEnvironmental EngineeringAqueous solutionIon exchangeHealth Toxicology and MutagenesisSodiumPotassiumIronchemistry.chemical_elementIndustrial WasteOxidesPollutionTitanateThermogravimetryIon ExchangeNickelchemistryMetals HeavyEnvironmental ChemistryInductively coupled plasmaWaste Management and DisposalWater Pollutants ChemicalNuclear chemistryJournal of hazardous materials
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