Search results for " Heterogeneity"

Dynamical heterogeneities in a supercooled Lennard-Jones liquid

1997

We present the results of a large scale molecular dynamics computer simulation study in which we investigate whether a supercooled Lennard-Jones liquid exhibits dynamical heterogeneities. We evaluate the non-Gaussian parameter for the self part of the van Hove correlation function and use it to identify ``mobile'' particles. We find that these particles form clusters whose size grows with decreasing temperature. We also find that the relaxation time of the mobile particles is significantly shorter than that of the bulk, and that this difference increases with decreasing temperature.

Correlation of primary relaxations and high-frequency modes in supercooled liquids. I. Theoretical background of a nuclear magnetic resonance experim…

2006

The question regarding a possible correlation of the time scales of primary and secondary relaxations in supercooled liquids is formulated quantitatively. It is shown how this question can be answered using spin-lattice relaxation weighted stimulated-echo experiments, which are presented in an accompanying paper [A. Nowaczyk, B. Geil, G. Hinze, and R. Böhmer, Phys. Rev. E 74, 041505 (2006)]. General theoretical expressions relevant for the description of such experiments in the presence of correlation effects are derived. These expressions are analyzed by Monte Carlo integration for various correlation scenarios also including exchange processes, which are the hallmark of dynamical heteroge…

Four-time rotational correlation functions

1998

A scheme to analyze four-time rotational correlation functions of any rank is developed and details for rank L = 1 and 2 are given. The scheme provides a transparent way for identifying deviations from simple Markovian dynamics as observed, e.g., in complex liquids close to the glass transition. The method should be applicable to NMR and optical multiple-pulse techniques as well as to photon correlation spectroscopy. Results are given for 2H-NMR multiple-pulse data in supercooled glycerol. We identify and analyze the dynamical heterogeneity of molecular reorientation in a range of 205 − 215 K close to the glass temperature Tg = 190 K.

Equilibrium/steady-state concept in phytoplankton ecology

2003

This paper summarises the outcomes of the 13th Workshop of the International Association of Phytoplankton Taxonomy and Ecology (IAP). The authors mostly addressed their contributions on the following topics: the effect of trophic state on the attainment of a steady-state; the establishment of equilibria in deep and shallow lakes; the role of spatial heterogeneity, disturbance, and stress in the establishment of equilibrium assemblages; the mechanisms leading to the steady state; the frequency and longevity of equilibrium phases, and the role of morphological and physiological plasticity of phytoplankton in maintaining the (apparently) same populations under different environmental condition…

Conformational heterogeneity of the point defects in Silica Glasses: Study of the lifetime of 2.7 eV phosphorescence band

2006

Analyse spatiale des disparités régionales dans l'Europe élargie

2004

The aim of this paper is to study the regional inequalities in the enlarged European Union using Exploratory Spatial Data Analysis applied to per capita GDP for 258 regions of EU27 over the period 1995-2000. Strong evidence in favor of global and local autocorrelation as well as spatial heterogeneity is found for the wealth distribution. We also show that the enlargement process leads to a new North-West - East polarization scheme instead of the previous results obtained in the literature highlighting a North-South polarization scheme. Implications for regional development and cohesion policies are finally explored.

Evolution of fitness in experimental populations of vesicular stomatitis virus

1996

Abstract The evolution of fitness in experimental clonal populations of vesicular stomatitis virus (VSV) has been compared under different genetic (fitness of initial clone) and demographic (population dynamics) regimes. In spite of the high genetic heterogeneity among replicates within experiments, there is a clear effect of population dynamics on the evolution of fitness. Those populations that went through strong periodic bottlenecks showed a decreased fitness in competition experiments with wild type. Conversely, mutant populations that were transferred under the dynamics of continuous population expansions increased their fitness when compared with the same wild type. The magnitude of …

Latent Class Model to Test the Preferences Heterogeneity in the Perceived Information by Public Transport Users

2012

The aim of analysis is to understand as not reliable information influence the user behaviour and how much disincentive the public transport use. For this purpose, a Stated Preference Survey has been carried out in order to know the preferences of public transport users related to information needs and uncertainty on the information provided by Advanced Traveller Information System (ATIS). The perceived uncertainty is defined as the information accuracy. In our study, it was considered the difference between forecasted or scheduled waiting time at the bus stop and/or metro station provided by ATIS, and experienced one by user, to catch the bus and/or metro respectively. A questionnaire has …

Abstract CT202: IVAC MUTANOME: Individualized vaccines for the treatment of cancer

2015

Abstract Cancer arises from the accumulation of genomic alterations and epigenetic changes that constitute a hallmark of cancer. Owing to the molecular heterogeneity in cancer, only a minor fraction of patients profit from approved therapies. Available targeted therapies can only address alterations common to a particular type of cancer and induce transient effects due to the generation of resistant sub-clones. In contrast, the IVAC MUTANOME project aims to immunologically target multiple cancer mutations uniquely expressed in a given patient's tumor. The IVAC MUTANOME approach should be applicable to the majority of patients irrespective of the tumor entity and offers the potential to expl…

Linkage analysis and disease models in benign familial infantile seizures: a study of 16 families.

2006

Summary: Purpose: Benign familial infantile seizures (BFIS) is a genetically heterogeneous condition characterized by partial seizures, onset age from 3 to 9 months, and favorable outcome. BFIS loci were identified on chromosomes 19q12-13.1 and 16p12-q12, allelic to infantile convulsions and choreathetosis. The identification of SCN2A mutations in families with only infantile seizures indicated that BFNIS and BFIS may show overlapping clinical features. Infantile seizures also were in a family with familial hemiplegic migraine and mutations in the ATP1A2 gene. We have examined the heterogeneous genetics of BFIS by means of linkage analysis. Methods: Sixteen families were examined. Probands …