Search results for " Home"
showing 8 items of 868 documents
The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress.
2021
Summary: Chromatin organization plays a crucial role in tissue homeostasis. Heterochromatin relaxation and consequent unscheduled mobilization of transposable elements (TEs) are emerging as key contributors of aging and aging-related pathologies, including Alzheimer’s disease (AD) and cancer. However, the mechanisms governing heterochromatin maintenance or its relaxation in pathological conditions remain poorly understood. Here we show that PIN1, the only phosphorylation-specific cis/trans prolyl isomerase, whose loss is associated with premature aging and AD, is essential to preserve heterochromatin. We demonstrate that this PIN1 function is conserved from Drosophila to humans and prevents…
Evaluation of the animal-assisted therapy in Alzheimer's disease
2017
Animal-assisted therapy sessions have been set up in a protected unit for patients with a dementia-related syndrome. The aim is to measure the effects of animal-assisted therapy on behavioural disorders in daily life and care. The results obtained provided some interesting areas to explore and recommendations with a view to optimising the implementation of such a system.
Mast cells as protectors of health.
2019
Mast cells (MCs), which are well known for their effector functions in T(H)2-skewed allergic and also autoimmune inflammation, have become increasingly acknowledged for their role in protection of health. It is now clear that they are also key modulators of immune responses at interface organs, such as the skin or gut. MCs can prime tissues for adequate inflammatory responses and cooperate with dendritic cells in T-cell activation. They also regulate harmful immune responses in trauma and help to successfully orchestrate pregnancy. This review focuses on the beneficial effects of MCs on tissue homeostasis and elimination of toxins or venoms. MCs can enhance pathogen clearance in many bacter…
‘Integration is not a one-way process’ : students negotiating meanings of integration and internationalization at home (IaH) in Finnish higher educat…
2023
Internationalization at home (IaH) policies in higher education institutions (HEIs) are rarely negotiated with and by students. Therefore, students’ takes on such policies could be missed opportunities for HEIs. This qualitative study investigates international and local students’ negotiations and meaning-making of integration and IaH as stated by institutional policies. The data consist of online forum entries and reports from small group discussions between 40 students in English medium master’s programs in Finland (Europe). The key concepts of ideology and imaginary serve as entries into data analysis, which consists of enunciative discourse analysis. The findings indicate a perceived hi…
Äitien luottamuksen rakentuminen kasvattajiin varhaiskasvatuksen aloituksessa
2020
Vanhempien ja kasvattajien kasvatusyhteistyön sujuvuus heijastuu siihen, millaiseksi varhaiskasvatuksen aloitus muodostuu lapsen kokemuksena. Parhaimmillaan yhteistyön alkuvaihe tukee luottamuksen rakentumista vanhempien ja kasvattajien välille. Tässä artikkelissa kiinnostus kohdistuu luottamuksen rakentumisen prosessiin äitien näkökulmasta. Tarkastelemme miten luottamus kasvattajiin varhaiskasvatuksen instituutiossa rakentuu äitien puheessa heidän pohtiessaan lapsensa ensi kuukausia varhaiskasvatuksessa. Teoriasidonnaisen sisällönanalyysin tuella tutkimme, onko puheesta löydettävissä Rempelin, Holmesin ja Zannanin (1985) kuvaamia luottamuksen rakentumisen tasoja. Aineistona ovat viiden noi…
Kielikäsitykset vanhustyössä - asukkaiden, hoitajien ja esimiesten käsityksiä hyvästä vuorovaikutuksesta ja kielenkäytöstä
2018
In this article, we apply critical discourse analysis and ethnography to examine conceptionsand experiences of inclusive interaction and language use in the context of eldercare in aretirement home. Our data consist of interviews with residents, nurses and managers intwo bilingual eldercare units, as well as ethnographic observations of communication andlanguage use in these units. Our analysis focuses especially on language ideologies andmetalinguistic aspects of inclusive language in the context of eldercare. On the basis of ouranalysis, we suggest that four elements are particularly central to elderly-centric language: 1)the quality, quantity and tone of interaction; 2) the practices of …
Vanhempien työ, työn siirräntä kotiin ja lasten hyvinvointi : kohtaamisia tuulikaapissa
2013
Zaangażowanie ojców zastępczych w realizację rodzicielskiej działalności w rodzinnych domach dziecka
2019
Przedmiotem rozważań niniejszego artykułu uczyniono zaangażowanie ojców zastępczych w realizację rodzicielskiej działalności w rodzinnych domach dziecka. Problem badawczy sformułowano w następującym pytaniu: Jaki jest poziom zaangażowania ojców zastępczych w realizację rodzicielskiej działalności, zarówno w wymiarze globalnym, jak i parcjalnym? W badaniach wzięło udział 55 ojców zastępczych z 55 rodzinnych domów dziecka. Zastosowanym narzędziem badawczym była Skala Zaangażowania Ojca Zastępczego w Opiekę i Wychowanie Dziecka. Opracowanie statystyczne zgromadzonego materiału pozwoliło udzielić następującej odpowiedzi: poziom zaangażowania ojców zastępczych w realizację rodzicielskiej działal…