Search results for " Humans"

showing 10 items of 2466 documents

Patient and physician views on the quality of care in inflammatory bowel disease: Results from SOLUTION-1, a prospective IG-IBD study

2014

Remarkable differences in quality of care (QoC) might be observed in different countries, affecting quality of life of inflammatory bowel disease (IBD) patients. The aim of this study was to assess patient and physician perceptions of the QoC in Italy.A multicentre observational study on the quality of care in IBD (SOLUTION-1) was conducted in 36 IG-IBD (Italian Group for Inflammatory Bowel Disease) centres in Italy. The QUOTE-IBD (Quality of Care Through the Patient's Eyes) questionnaire was administered to IBD patients and to the attending physicians. The Quality Impact (QI) score summarises the QUOTE-IBD questionnaire, and a QI9 is considered satisfactory.Nine-hundred-ninety-two patients…

AdultMalemedicine.medical_specialtyquality impact score; quote-ibd; quality of careAdolescentAttitude of Health PersonnelQuality impact score; Quality of care; QUOTE-IBD; Adolescent; Adult; Aged; Aged 80 and over; Attitude of Health Personnel; Clinical Competence; Continuity of Patient Care; Female; Humans; Inflammatory Bowel Diseases; Italy; Male; Middle Aged; Patient Education as Topic; Patient Satisfaction; Professional Autonomy; Prospective Studies; Surveys and Questionnaires; Young Adult; Quality of Health Care; Medicine (all)Quality impact scoreGastroenterologyInflammatory bowel diseaseYoung AdultQUOTE-IBDPatient Education as TopicSurveys and QuestionnairesInternal medicineHealth care80 and overPhysician perceptionHumansMedicineProfessional AutonomyPharmaceutical SolutionsProspective StudiesQuality of careCompetence (human resources)AgedQuality of Health CareAged 80 and overbusiness.industryMedicine (all)Quality of careGastroenterologyQuality impact score; Quality of care; QUOTE-IBD; GastroenterologyGeneral MedicineContinuity of Patient CareMiddle AgedInflammatory Bowel Diseasesmedicine.diseasedigestive system diseasesItalyPatient SatisfactionFamily medicineFemaleContinuity of careObservational studyClinical CompetencebusinessJournal of Crohn's and Colitis
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Typical trigeminal neuralgia by an atypical compression: case report and review of the literature.

2014

Aim Trigeminal neuralgia is a disabling form of facial pain that causes a considerable discomfort and a marked reduction in the quality of life. Although neurovascular compression is often associated with trigeminal neuralgia, other intracranial pathologies can result in compression along the nerve. Case description The authors report a case of a patient suffering from a typical left trigeminal neuralgia affecting both the second and the third branches. Neuroradiological examinations showed the presence of an arachnoid cyst located in the left temporal lobe, contiguous with the Meckel's cave, eroding the greater wing of the sphenoid bone. Following a meticulous decision-making process the p…

AdultMalemedicine.medical_specialtytypical trigeminal neuralgiaSphenoid bonePainMagnetic resonance angiographyArachnoid cystTrigeminal neuralgiaSphenoid BonemedicineHumansCranial nerve diseaseArachnoid cyst; Conservative treatment; Trigeminal neuralgia; Adult; Analgesics Non-Narcotic; Carbamazepine; Cranial Nerve Diseases; Humans; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Male; Nerve Compression Syndromes; Pain; Sphenoid Bone; Treatment Outcome; Trigeminal Neuralgia; Neurology (clinical); SurgeryPathologicalmedicine.diagnostic_testbusiness.industrySettore MED/27 - NeurochirurgiaNerve Compression SyndromesCarbamazepineAnalgesics Non-NarcoticTrigeminal Neuralgiamedicine.diseaseMagnetic Resonance ImagingCranial Nerve Diseasesnervous system diseasesSurgeryNerve compression syndromebody regionsCarbamazepineTreatment OutcomeSurgeryNeurology (clinical)medicine.symptombusinessMagnetic Resonance Angiographymedicine.drug
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Prefrontal and temporo-parietal involvement in taking others' perspective: TMS evidence.

2008

INTRODUCTION: Understanding the mental states of others entails a number of cognitive processes known as Theory of Mind (ToM). Behavioural and functional neuroimaging evidence suggests that prefrontal and temporo-parietal cortices are involved in these abilities. The present study was aimed at investigating the role of the dorsolateral prefrontal cortex and temporo-parietal junction in ToM by using a repetitive transcranial magnetic stimulation (rTMS) paradigm. MATERIAL AND METHODS: Eleven healthy subjects participated in the study. The experimental ToM procedure was constituted by false belief and faux-pas written stories. Subjects were evaluated in baseline condition (Sham) and after 1Hz …

AdultMalemedicine.medical_treatmentCulturePrefrontal CortexNeurosciences. Biological psychiatry. NeuropsychiatryTHEORY OF MINDbehavioral disciplines and activitiesFunctional neuroimagingTheory of mindParietal Lobemental disordersmedicineReaction TimeSocial Perception; Culture; Humans; Temporal Lobe; Adult; Prefrontal Cortex; Transcranial Magnetic Stimulation; Parietal Lobe; Male; Female; Reaction TimeHumansBRAINPrefrontal cortexSettore M-PSI/02 - Psicobiologia E Psicologia FisiologicaParietal lobeCognitionGeneral MedicineTranscranial Magnetic StimulationTemporal LobeTranscranial magnetic stimulationDorsolateral prefrontal cortexNeuropsychology and Physiological Psychologymedicine.anatomical_structureNeurologyMentalizationnervous systemSocial PerceptionmentalizingSettore MED/26 - NeurologiaFemaleNeurology (clinical)PsychologyNeurosciencepsychological phenomena and processesRC321-571Cognitive psychologyResearch Article
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Recognition memory and prefrontal cortex: Dissociating recollection and familiarity processes using rTMS

2008

Recognition memory can be supported by both the assessment of the familiarity of an item and by the recollection of the context in which an item was encountered. The neural substrates of these memory processes are controversial. To address these issues we applied repetitive transcranial magnetic stimulation (rTMS) over the right and left dorsolateral prefrontal cortex (DLPFC) of healthy subjects performing a remember/know task. rTMS disrupted familiarity judgments when applied before encoding of stimuli over both right and left DLPFC. rTMS disrupted recollection when applied before encoding of stimuli over the right DLPFC. These findings suggest that the DLPFC plays a critical role in recog…

AdultMalemedicine.medical_treatmentNeurosciences. Biological psychiatry. NeuropsychiatryContext (language use)Recognition (Psychology)behavioral disciplines and activitiesPrefrontal cortexNORecognition memoryJudgmentRecollectionEncoding (memory)mental disordersmedicineHumansJudgment; Memory; Recognition (Psychology); Humans; Adult; Mental Recall; Prefrontal Cortex; Transcranial Magnetic Stimulation; Male; FemalePrefrontal cortexTMS; MEMORYLeft dorsolateral prefrontal cortexRecognition memoryRecallSettore M-PSI/02 - Psicobiologia E Psicologia FisiologicaMEMORYHealthy subjectsRecognition PsychologyGeneral MedicineFamiliarityTranscranial Magnetic StimulationTranscranial magnetic stimulationNeuropsychology and Physiological Psychologynervous systemNeurologyTMSMental RecallFemaleSettore MED/26 - NeurologiaNeurology (clinical)Psychologypsychological phenomena and processesFamiliarity; Prefrontal cortex; Recognition memory; Recollection;Research ArticleRC321-571Cognitive psychology
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Prognostic factors of macrophage activation syndrome, at the time of diagnosis, in adult patients affected by autoimmune disease: Analysis of 41 case…

2016

Macrophage activation syndrome (MAS) is a rare, life-threatening disease in which early diagnosis and aggressive therapeutic strategy may improve the outcome. Due to its rarity, epidemiologic data are still lacking. Hyperferritinemia is frequently associated with MAS and might modulate the cytokine storm, which is involved in the development of multiple organ failure. In this paper, we investigated clinical data, treatments, and outcome of a homogeneous cohort of 41 adult MAS patients, complicating autoimmune rheumatic diseases. MAS-related death occurred in 17 patients (42.5%) during the follow-up, and older age and increased serum ferritin levels, at the time of diagnosis, were significan…

AdultMalemusculoskeletal diseases0301 basic medicinemedicine.medical_specialtyImmunologyAdult onset Still's disease; Hyperferritinemic syndrome; Macrophage activation syndrome; Adult; Ambulatory Care Facilities; Autoimmune Diseases; Female; Humans; Immunosuppressive Agents; Macrophage Activation Syndrome; Male; Middle Aged; Prognosis; Retrospective Studies; Treatment Outcome; Immunology and Allergy; ImmunologyDiseaseAmbulatory Care FacilitiesAutoimmune Diseases03 medical and health sciences0302 clinical medicineAdult onset Still's diseaseInternal medicineHumansImmunology and AllergyMedicineRetrospective Studies030203 arthritis & rheumatologyAutoimmune diseaseAdult patientsbusiness.industryMortality ratefungiRetrospective cohort studyMiddle AgedPrognosisHyperferritinemic syndromemedicine.diseasebody regionsSettore MED/16 - ReumatologiaTreatment Outcome030104 developmental biologyMacrophage activation syndromeMacrophage activation syndromeCohortImmunologyFemalelipids (amino acids peptides and proteins)businessCytokine stormImmunosuppressive Agentshormones hormone substitutes and hormone antagonistsAutoimmunity Reviews
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Efficacy and pharmacological appropriateness of cinnarizine and dimenhydrinate in the treatment of vertigo and related symptoms

2021

Vertigo is not itself a disease, but rather a symptom of various syndromes and disorders that jeopardize balance function, which is essential for daily activities. It is an abnormal sensation of motion that usually occurs in the absence of motion, or when a motion is sensed inaccurately. Due to the complexity of the etiopathogenesis of vertigo, many pharmacological treatments have been tested for efficacy on vertigo. Among these drugs, cinnarizine, usually given together with dimenhydrinate, appears to be the first-line pharmacotherapy for the management of vertigo and inner ear disorders. Based on these considerations, the present non-interventional study aimed to investigate the clinical …

AdultMalepharmacological treatment of vertigomedicine.medical_specialtyCinnarizineHealth Toxicology and MutagenesisDiseasedimenhydrinateArticleCinnarizine Dimenhydrinate Dizziness Pharmacological treatment of vertigo Vertigo Adult Double-Blind Method Drug Combinations Female Histamine H1 Antagonists Humans Male Middle Aged Cinnarizine Dimenhydrinatevertigo03 medical and health sciences0302 clinical medicinePharmacotherapyDouble-Blind MethodVertigoInternal medicinemedicineotorhinolaryngologic diseasesHumans030212 general & internal medicinecinnarizine030223 otorhinolaryngologydizzinessBalance (ability)biologybusiness.industryPublic Health Environmental and Occupational HealthRMiddle Agedbiology.organism_classificationDimenhydrinateDrug CombinationsTolerabilityConcomitantHistamine H1 AntagonistsMedicineFemalebusinessmedicine.drug
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Sociodemographic factors in fibromyalgia: results from the Italian Fibromyalgia Registry

2022

ObjectiveFibromyalgia (FM) is a chronic musculoskeletal pain syndrome of unknown aetiopathogenesis. Its development and maintenance are related to the interplay of biological, psychological, and contextual factors. Among the contextual factors, sociodemographic aspects are poorly elucidated. This study aimed to evaluate the relationships between sociodemographic/ clinical factors and symptom severity measures using a web-based registry of patients with FM.MethodsAdult patients with an ACR 2010/2011 diagnosis of FM underwent a clinical evaluation and were asked to complete questionnaires covering their sociodemographic data (gender, age, marital status, educational level), and disease-specif…

AdultMalesociodemographic factorsImmunologyReproducibility of ResultsSeverity of Illness IndexRheumatologysociodemographic factors.Surveys and QuestionnairesQuality of LifegenderImmunology and AllergyHumansFemalefibromyalgiaRegistriesChronic Painadult; female; humans; male; quality of life; registries; reproducibility of results; severity of illness index; sociodemographic factors; surveys and questionnaires; chronic pain; fibromyalgia
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On orienting the hand to reach and grasp an object.

1996

Subjects were required to reach and grasp a parallelepiped, the position, orientation and size of which were varied. The kinematics of reaching and grasping movements was studied in full vision and in no vision conditions. Both direction and movement amplitude of reaching were affected by object orientation. Conversely, both the time course of finger axis orientation and the angular displacement of the hand at wrist were influenced by object position. These results were not modified by the absence of visual control. Finger aperture during grasping was affected by both object size and orientation. This latter result was not due to a distorted size perception, as shown by a control matching e…

AdultMalevisionreaching to graspgenetic structuresMovementObject (grammar)KinematicsSettore BIO/09Visual controlocularFeedbackFingersOrientation (geometry)OrientationHumansComputer visionLightingVision OcularCommunicationAngular displacementbusiness.industryGeneral NeuroscienceMovement; male; vision ocular; fingers; lighting; female; hand; perception; adult; feedback; orientation; humansMotor controlBody movementHandbody regionskinematicsFemalePerceptionArtificial intelligenceSize PerceptionPsychologybusinessobject orientationpsychological phenomena and processesNeuroreport
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Second-line Eribulin in Triple Negative Metastatic Breast Cancer patients. Multicentre Retrospective Study: The TETRIS Trial

2021

Introduction: Large and consistent evidence supports the use of eribulin mesylate in clinical practice in third or later line treatment of metastatic triple negative breast cancer (mTNBC). Conversely, there is paucity of data on eribulin efficacy in second line treatment. Methods: We investigated outcomes of 44 mTNBC patients treated from 2013 through 2019 with second line eribulin mesylate in a multicentre retrospective study involving 14 Italian oncologic centres. Results: Median age was 51 years, with 11.4% of these patients being metastatic at diagnosis. Median overall survival (OS) and progression free survival (PFS) from eribulin starting were 11.9 (95%CI: 8.4-15.5) and 3.5 months (95…

AdultOncologyEribulin Mesylatemedicine.medical_specialtyeribulin mesylatemedicine.medical_treatmentTriple Negative Breast Neoplasmschemotherapytriple negative metastatic breast cancer03 medical and health scienceschemistry.chemical_compound0302 clinical medicineadjuvantInternal medicineAntineoplastic Combined Chemotherapy Protocols80 and overmedicineHumansChemotherapy; Efficacy outcomes; Eribulin mesylate; Toxicity outcomes; Triple negative metastatic breast cancerProgression-free survivalFuransAdverse effectTriple-negative breast cancerAgedNeoplasm StagingRetrospective StudiesAged 80 and overChemotherapybusiness.industryRetrospective cohort studyGeneral MedicineKetonesMiddle Agedmedicine.diseaseMetastatic breast cancerNeoadjuvant TherapyProgression-Free SurvivalchemistryChemotherapy AdjuvantFemale030211 gastroenterology & hepatologytoxicity outcomesefficacy outcomeschemotherapy; efficacy outcomes; eribulin mesylate; toxicity outcomes; triple negative metastatic breast cancer; adult; aged; aged; 80 and over; antineoplastic combined chemotherapy protocols; chemotherapy; adjuvant; female; furans; humans; ketones; middle aged; neoadjuvant therapy; neoplasm staging; progression-free survival; retrospective studies; triple negative breast neoplasmsbusinessResearch PaperEribulinInternational Journal of Medical Sciences
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Influence of Intraperitoneal Dissemination Assessed by Laparoscopy on Prognosis of Advanced Ovarian Cancer: An Exploratory Analysis of a Single-Insti…

2014

Purpose: The aim of this study was to investigate whether preoperative laparoscopic evaluation of the dissemination of disease may have an independent impact on survival in advanced epithelial ovarian cancer (AEOC).Methods: All AEOC women were submitted to staging laparoscopy before receiving primary debulking surgery (PDS) or neoadjuvant chemotherapy (NACT). All study women received a laparoscopic score (predictive index value [PIV]) and were stratified into three groups based on volume of disease: high tumor load (HTL) for PIV ≥8, intermediate tumor load (ITL) for PIV equal to 6 and 4, and low tumor load (LTL) for PIV 1 cm in 15 cases (9.1 %). When stratifying the whole population accordi…

AdultOncologymedicine.medical_specialtyNeoplasm ResidualAdult; Aged; Aged; 80 and over; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Laparoscopy; Middle Aged; Neoplasm Staging; Neoplasm; Residual; Ovarian Neoplasms; Peritoneal Neoplasms; Prognosis; Retrospective Studies; Survival Rate; Tumor BurdenPopulationlaparoscopySurgical oncologyInternal medicineHumansMedicineeducationLaparoscopySurvival ratePeritoneal NeoplasmsAgedNeoplasm StagingRetrospective StudiesAged 80 and overOvarian Neoplasmseducation.field_of_studymedicine.diagnostic_testPerformance statusbusiness.industryMedicine (all)Retrospective cohort studyMiddle AgedPrognosismedicine.diseaseDebulkingCombined Modality TherapyTumor BurdenSurvival Rateovarian cancerSettore MED/40 - GINECOLOGIA E OSTETRICIAOncologyFemaleSurgerybusinessOvarian cancerFollow-Up StudiesAnnals of Surgical Oncology
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