6533b7dcfe1ef96bd12716fc

RESEARCH PRODUCT

Recognition memory and prefrontal cortex: Dissociating recollection and familiarity processes using rTMS

Silvia SalernoGiovanni Augusto CarlesimoMassimiliano OliveriPatrizia TurrizianiCarlo CaltagironeFloriana CostanzoGiacomo Koch

subject

AdultMalemedicine.medical_treatmentNeurosciences. Biological psychiatry. NeuropsychiatryContext (language use)Recognition (Psychology)behavioral disciplines and activitiesPrefrontal cortexNORecognition memoryJudgmentRecollectionEncoding (memory)mental disordersmedicineHumansJudgment; Memory; Recognition (Psychology); Humans; Adult; Mental Recall; Prefrontal Cortex; Transcranial Magnetic Stimulation; Male; FemalePrefrontal cortexTMS; MEMORYLeft dorsolateral prefrontal cortexRecognition memoryRecallSettore M-PSI/02 - Psicobiologia E Psicologia FisiologicaMEMORYHealthy subjectsRecognition PsychologyGeneral MedicineFamiliarityTranscranial Magnetic StimulationTranscranial magnetic stimulationNeuropsychology and Physiological Psychologynervous systemNeurologyTMSMental RecallFemaleSettore MED/26 - NeurologiaNeurology (clinical)Psychologypsychological phenomena and processesFamiliarity; Prefrontal cortex; Recognition memory; Recollection;Research ArticleRC321-571Cognitive psychology

description

Recognition memory can be supported by both the assessment of the familiarity of an item and by the recollection of the context in which an item was encountered. The neural substrates of these memory processes are controversial. To address these issues we applied repetitive transcranial magnetic stimulation (rTMS) over the right and left dorsolateral prefrontal cortex (DLPFC) of healthy subjects performing a remember/know task. rTMS disrupted familiarity judgments when applied before encoding of stimuli over both right and left DLPFC. rTMS disrupted recollection when applied before encoding of stimuli over the right DLPFC. These findings suggest that the DLPFC plays a critical role in recognition memory based on familiarity as well as recollection.

yearjournalcountryeditionlanguage
2008-01-01
10.1155/2008/568057http://hdl.handle.net/11392/2452583