Search results for " IMMUNITY"
showing 10 items of 618 documents
Regalismo e inmunidad eclesiástica en la España del siglo XVIII: la resistencia del clero valenciano a la imposición del estanco del tabaco
2007
The charters abolition decree of the Kingdoms of Valencia and Aragon kept the traditional regulation on the jurisdiction and ecclesiastic immunity, and this exception was ratified in the Royal Order the 7th of September in 1707. As the members of this class thought that it was implying a reinforcement of their privileges, they presented an intense resistance to the imposition of the tobacco monopoly, which the monarchy considered as a «well-known royalty» inherent in its sovereignty. Initially, the opposition was assumed by the ecclesiastic hierarchy and it generated jurisdictional conflicts so serious that Philip V proceeded to the emission of dispositions in favour of his royal prerogativ…
Suppression of humoral immune response against herpes simplex virus induced by defective strains, ts- and TK- mutants.
1988
Suppression of humoral antibody formation against HSV is not only induced by replicating Herpes simplex virus type 2 (HSV-2) but also by the defective strain ANG and the deletion mutant 1301 of Herpes simplex virus type 1 (HSV-1). Moreover, ts-mutants A, H, K, S, 1201 and 1208 of HSV-1 as well as some ts-mutants of HSV-2 and “defective-interfering” particles of HSV-1 after high multiplicity of infection-passages induced suppression. Treatment of infected mice with ACG reduced antibody-formation but did not result in suppression. UV-irradiation of the antibody producing strain Len of HSV-1 strongly reduces antibody formation and induces suppression. Experiments using a series of intertypic r…
Liver fibrosis: Common mechanisms and antifibrotic therapies
2015
Liver fibrosis and in particular cirrhosis have become major endpoints in clinical trials of patients with chronic liver diseases. Here, viral hepatitis, alcoholic and non-alcoholic steatohepatitis have become the major etiologies. We have made great progress in our understanding of the mechanisms and the cell biology of liver fibrosis and have already made the transition from preclinical testing of antifibrotic agents and strategies towards clinical translation. There continues to be an urgent need for specific antifibrotic therapies, despite the advent of highly potent antiviral agents that can even induce regression of advanced fibrosis. This review addresses central mechanisms and cells…
Innate immunity but not NLRP3 inflammasome activation correlates with severity of stable COPD.
2014
Background In models of COPD, environmental stressors induce innate immune responses, inflammasome activation and inflammation. However, the interaction between these responses and their role in driving pulmonary inflammation in stable COPD is unknown. Objectives To investigate the activation of innate immunity and inflammasome pathways in the bronchial mucosa and bronchoalveolar lavage (BAL) of patients with stable COPD of different severity and control healthy smokers and non-smokers. Methods Innate immune mediators (interleukin (IL)-6, IL-7, IL-10, IL-27, IL-37, thymic stromal lymphopoietin (TSLP), interferon γ and their receptors, STAT1 and pSTAT1) and inflammasome components (NLRP3, NA…
Oligodendrocyte-specific FADD deletion protects mice from autoimmune-mediated demyelination.
2010
Abstract Apoptosis of oligodendrocytes (ODCs), the myelin-producing glial cells in the CNS, plays a central role in demyelinating diseases such as multiple sclerosis and experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. To investigate the mechanism behind ODC apoptosis in EAE, we made use of conditional knockout mice lacking the adaptor protein FADD specifically in ODCs (FADDODC-KO). FADD mediates apoptosis by coupling death receptors with downstream caspase activation. In line with this, ODCs from FADDODC-KO mice were completely resistant to death receptor-induced apoptosis in vitro. In the EAE model, FADDODC-KO mice followed an ameliorated clinical di…
Electric Power Quality Evaluation in the Presence of Electromagnetic Emissions
2013
The measurements for the assessment of the electric power quality are often carried out in hostile electromagnetic environments. The aim of the paper is analyzing if and how both radiated and conducted electromagnetic emissions can disturb the measurement system used to quantify these disturbances. To achieve the target, an experimental approach is proposed, which, by means of a simple and fast test, allows establishing if the real electromagnetic environment, where power quality analysis is performed, can alter the measurements. © 2013 IEEE.
Sliding mode torque control of an induction motor for automotive application with sliding mode flux observer
2016
In this paper, the performance of two control systems of induction motors for automotive applications were compared in order to highlight the differences in terms of response speed, robustness and noise immunity. The first system is realized through a field-oriented control with PI controllers, while the second system is realized through a field-oriented control with Sliding Mode Controllers. Both controls are designed to follow the torque references as required for the vehicles and are tested with typical load profiles of vehicles. It also designed a sliding mode observer flux.
Virtual Instruments: Uncertainty Evaluation in the Presence of Electromagnetic Interferences
2007
The electromagnetic interferences can influence the performances of a virtual instrument; consequently, in a generic measurement performed by using these instruments, the related uncertainty values can increase. In the paper, we report the results of various experimental tests performed with the aim to check if and how the radiated and/or conducted disturbances affect the instruments' characteristics and, in particular, the single uncertainty sources. Starting from these results and applying an already proposed method for the uncertainty estimation in the measurements performed by means of virtual instruments, it is possible to take into account and to evaluate the contribute of the electro…
Suppression of humoral antibody formation against sheep red blood cells by infections with HSV-2 and the influence of mouse cytomegalovirus
1987
HSV-2 infections suppress the antibody response to HSV-1 but do not impair the mouse cytomegalo virus (MCMV) antibody generating system. In contrast, the sheep red blood cell (SRBC) IgM response is impaired by preinfections with HSV-2 but not with HSV-1. From the time kinetics of this suppression it can be concluded that only a certain submechanism "spills over" to the SRBC system. MCMV suppresses the antibody formation induced by HSV-1.
Nanog Regulates Primordial Germ Cell Migration Through Cxcr4b
2010
Abstract Gonadal development in vertebrates depends on the early determination of primordial germ cells (PGCs) and their correct migration to the sites where the gonads develop. Several genes have been implicated in PGC specification and migration in vertebrates. Additionally, some of the genes associated with pluripotency, such as Oct4 and Nanog, are expressed in PGCs and gonads, suggesting a role for these genes in maintaining pluripotency of the germ lineage, which may be considered the only cell type that perpetually maintains stemness properties. Here, we report that medaka Nanog (Ol-Nanog) is expressed in the developing PGCs. Depletion of Ol-Nanog protein causes aberrant migration of …