Search results for " INDUCTION"
showing 10 items of 526 documents
Molecular studies on the toxifying effects by genetically engineered cytochromes P450.
1999
After almost two decades, it is now evident that methodology based on molecular biology and gene technology has dramatically changed the way basic and applied toxicology is being performed. It star...
Constitutive and inducible expression of CYP enzymes in immortal hepatocytes derived from SV40 transgenic mice
2003
1. The expression of liver-specific transcription factors and cytochrome P450 (CYP) enzymes have been studied in three new hepatocyte-like cell lines derived from SV Delta 202 transgenic mice: AMH-Delta 202 (adult mouse hepatocytes), TAMH-Delta 202 (tumour-derived adult mouse hepatocytes) and NMH-Delta 202 (newborn mouse hepatocytes). 2. mRNA levels of liver-enriched transcription factors such as D-element binding protein (DBP), liver-enriched transcription activating protein (LAP) and the hepatic nuclear factors (HNF) 1, 2 and 3 in all Delta 202 transgenic hepatocyte lines were similar to those in the wild-type liver and in primary mouse hepatocytes. 3. Analysis of basal CYP activities and…
A framework for remission in SLE
2017
ObjectivesTreat-to-target recommendations have identified ‘remission’ as a target in systemic lupus erythematosus (SLE), but recognise that there is no universally accepted definition for this. Therefore, we initiated a process to achieve consensus on potential definitions for remission in SLE.MethodsAn international task force of 60 specialists and patient representatives participated in preparatory exercises, a face-to-face meeting and follow-up electronic voting. The level for agreement was set at 90%.ResultsThe task force agreed on eight key statements regarding remission in SLE and three principles to guide the further development of remission definitions:1. Definitions of remission wi…
BIOAVAILABILITY TO JUVENILE RAINBOW TROUT (ONCORYNCHUS MYKISS) OF RETENE AND OTHER MIXED-FUNCTION OXYGENASE-ACTIVE COMPOUNDS FROM SEDIMENTS
2002
Retene (7-isopropyl-1-methylphenanthrene) is a naturally formed polycyclic aromatic hydrocarbon (PAH) that causes teratogenicity in fish larvae and induction of cytochrome P450 (CYP1A) enzymes. Retene occurs at high concentrations (or =3,300 microg/g dry wt) in surface sediments contaminated by resin acids from pulp mill effluents. To assess the environmental risks of retene, it is important to evaluate conditions affecting its bioavailability and accumulation by fish. Fingerling rainbow trout were exposed to retene-spiked or naturally contaminated sediments and sampled after 4 d to determine liver CYP1A activity and concentrations of retene metabolites in bile as indicators of retene accum…
Reversal of asymmetric induction in stereoselective strecker synthesis on galactosyl amine as the chiral matrix
1988
Abstract The reversal of the direction of asymmetric induction in Lewis acid catalyzed Strecker synthesis using the 2,3,4,6-tetra-O-pivaloyl-β-D-galactopyranosyl amine 1 is described. In isopropanol or tetrahydrofuran 1 had given ( R )-diastereomers of the corresponding α-amino nitriles preferably. However, in chloroform in the presence of heterogeneous zinc chloride the same auxiliary alternatively leads to an excess of the ( S )-diastereomers.
A distinct subset of HLA-DR+-regulatory T cells is involved in the induction of preterm labor during pregnancy and in the induction of organ rejectio…
2010
Regulatory T cells (Tregs) are known to suppress alloimmune responses during pregnancy and post organ transplantation. We demonstrate that a distinct subset of FoxP3(+)DR(+)-Tregs among the total CD4(+)CD127(low+/-)CD25(+)-Treg cell pool is critically involved in preterm labor induction and kidney transplant rejection as well. Compared to healthy pregnancies and non-rejecting kidney recipients, we found that the percentage of the FoxP3(+)DR(+)-Treg subset was not reduced, but that the level of HLA-DR expression of such Tregs was strongly diminished in preterm laboring women and in patients with acute renal allograft rejection. In addition, both patient collectives showed a significantly red…
Closed Theories, Falsificationism and Non-Cumulative Progress
2020
It is argued that scientific progress occurs not with the cumulative growth of knowledge or when theories get closer to the truth but with discovering new domains and new theories that fit these domains. This horizontal view on the direction of scientific progress (in contrast to vertical, when we aim to get from here to the abstract and ephemeral truth) allows avoiding traditional objections posed by the incommensurability thesis and pessimistic induction, namely, that radical theory changes leave no room for progress. According to this perspective, the discovery of quantum mechanics as a new field of inquiry is a progress in itself, since this discovery had opened up a new distinctive dom…
Emotionserleben und somatische Beschwerden
2017
Zusammenfassung. Theoretischer Hintergrund: Aktuelle Modelle der Wahrnehmung körperlicher Beschwerden gehen davon aus, dass negative emotionale Zustände (z. B. Angst und Traurigkeit) eine zentrale Rolle bei der Symptomwahrnehmung spielen. Eine kausale Wirkung von Ärger auf den körperlichen Symptombericht wurde hingegen noch nicht ausreichend nachgewiesen. Fragestellung: Führt eine experimentelle Induktion von Ärger und Traurigkeit zu einem verstärkten Bericht körperlicher Beschwerden? Methode: 90 Studienteilnehmende wurden zufällig drei experimentellen Bedingungen zugewiesen. Mit einer autobiografischen Methodik wurden Ärger (n = 30) und Traurigkeit (n = 30) induziert. Eine dritte Gruppe (…
HDlive ultrasound images in assisted reproduction treatment.
2012
Abstract The volume ultrasound technology software known as the HDlive technique represents an innovative tool, a step towards an even more realistic anatomical visualization of pelvic organ structures. HDlive can help improve physician–patient communication with the aid of life-like images and might prove useful in the field of assisted reproduction treatment. The clinical application of this novel ultrasound technology in assisted reproduction treatment deserves scientific evaluation.
Small Things, Micro-Affirmations and Helpful Professionals Everyday Recovery-Orientated Practices According to Persons with Mental Health Problems
2018
The aim of this study is to present concrete descriptions of the content in the construction of helpful relationships with staff, according to users. Starting with the re-occurring concept of the meaning of "little things" in recovery studies, a literature review was done. A thematic analysis shows that small things play an important role in improving a person's sense of self. Small things seem to be an invisible but effective parts of a recovery-orientated practice, but they might be defined as unprofessional and their efficacy negated.