Search results for " Index"
showing 10 items of 4978 documents
Approximate Matching over Biological RDF Graphs
2012
In the last few years, the amount of biological interaction data discovered and stored in public databases (e.g., KEGG [2]) considerably increased. To this aim, RDF is a powerful representation for interactions (or pathways), since they can be modeled as directed graphs, often referred to as biological networks, where nodes represent cellular components and the (labeled or unlabeled) edges correspond to interactions among components. Often for a given organism some components are known to be linked by well studied interactions. Such groups of components are called modules and they can be represented by sub-graphs in the corresponding biological network model. At today, one of the most impor…
Profit Margin Ratio, Markup, Profit Margin Per Unit, Economic Profit, and Profitability as Objectives for the Firm: An Economic Point-of-View
2015
We study five operational objectives for the firm: three marketing objectives (maximizing profit-margin ratio, maximizing markup, and maximizing profit-margin-per-unit), and two financial objective (maximizing economic profit (i.e., EVA) and maximizing profitability), as alternatives to the scholarly objective of maximizing profit. We prove that (i) Sales are lowest for profit-margin-per-unit, intermediate for profit-margin ratio and markup, and highest for profit maximization. Input consumption, including labor, is lower. Prices are in the reverse order. In terms of profit, profit-margin ratio, markup, and profit-margin-per-unit are necessarily less efficient than the classical profit maxi…
Retail pricing decisions and product category competitive structure
2010
This study addresses the use of demand forecasting techniques by retailers to support their decision making. Specifically, the authors propose a pricing decision support model for retailers to estimate optimal prices, whose output depends on the configuration of a supporting measurement model. The measurement model is a demand function that relates sales and prices within the category; optimal prices are those whose effects on demand and retail margins maximize the category's profitability. This investigation focuses particularly on the role of competitive structure, such that the authors consider two types of price competition asymmetries for demand forecasting: those depending on the bran…
Fabrication and Characterization of Polymeric Optical Waveguides Using Standard Silicon Processing Technology
2005
We report the fabrication and characterization of a rib polymeric waveguide having a thick layer of oxidized porous silicon as an innovative solution for the lower cladding. The waveguide was fabricated using standard silicon substrates and Si-based technology. The multimodal guiding structure has a polymethylmetacrylate (PMMA) core and the innovative lower cladding was obtained by thermal oxidation of a porous silicon layer. The waveguide does not have the upper cladding. Propagation loss measurements were performed at 1.48 /spl mu/m using the cut-back method. We obtained propagation loss of about 1.7 dB/cm, confirming the possibility to use the porous silicon oxide as the lower cladding l…
The Properties of Atmospheric Aerosol Particles as Functions of the Relative Humidity at Thermodynamic Equilibrium with the Surrounding Moist Air
1976
Publisher Summary The chapter addresses the problems in aerosol measuring techniques and selection of sampling and measuring methods. Theoretic evaluation of mass, size, mean density, and mean refractive index as functions of the relative humidity is discussed. The chapter also discusses techniques for measuring the mass as a function of the relative humidity; determination of the mean density; and measuring the mean complex index of refraction. Results of the measurements, discussion of the results, coefficients of mass increase, mean densities and real parts of the mean complex index of refractions, and applicability of the results are also described. Finally, the chapter then reviews the…
Descripción de dispositivo y método quirúrgico para optimizar la posición de la prótesis de Montgomery en la Tiroplastia de medialización
2017
Título Descripción de dispositivo y método quirúrgico para optimizar la posición de la prótesis de Montgomery en la Tiroplastia de Medialización. Introducción y objetivo La cirugía del esqueleto laríngeo para la medialización de la cuerda vocal paralizada la describió por primera vez Payr en 1915 y fue desarrollada más ampliamente por Isshiki a partir de 1974. Los conceptos presentados revolucionaron el manejo quirúrgico de la parálisis de cuerda vocal. Desde entonces, mejoras considerables de la técnica han sido descritas por numerosos autores. En la actualidad, la mayoría de clínicos utilizan prótesis no reabsorbibles de diferentes tamaños que se engastan a la ventana cartilaginosa realiz…
Development of a versatile, easy and rapid atmospheric monitor for benzene, toluene, ethylbenzene and xylenes determination in air
2009
Abstract A new procedure for the passive sampling in air of benzene, toluene, ethylbenzene and xylene isomers (BTEX) is proposed. A low-density polyethylene layflat tube filled with a mixture of solid phases provided a high versatility tool for the sampling of volatile compounds from air. Several solid phases were assayed in order to increase the BTEX absorption in the sampler and a mixture of florisil and activated carbon provided the best results. Direct head-space-gas chromatography–mass spectrometry (HS-GC–MS) measurement of the whole deployed sampler was employed for a fast determination of BTEX. Absorption isotherms were used to develop simple mathematical models for the estimation of…
Cardiovascular effects of air pollution
2017
Air pollution is composed of particulate matter (PM) and gaseous pollutants, such as nitrogen dioxide and ozone. PM is classified according to size into coarse particles (PM 10), fine particles (PM 2.5) and ultrafine particles. We aim to provide an original review of the scientific evidence from epidemiological and experimental studies examining the cardiovascular effects of outdoor air pollution. Pooled epidemiological studies reported that a 10 μg/m 3 increase in long-term exposure to PM 2.5 was associated with an 11% increase in cardiovascular mortality. Increased cardiovascular mortality was also related to long-term and short-term exposure to nitrogen dioxide. Exposure to air pollution…
Profile of glycopyrronium for once-daily treatment of moderate-to-severe COPD
2012
Bronchodilators are central in the symptomatic management of chronic obstructive pulmonary disease (COPD). Long-acting muscarinic antagonists (LAMAs) and long-acting β(2)-agonists (LABAs) are the main classes of long-acting bronchodilators. To date, tiotropium is the only once-daily LAMA available for the treatment of COPD. Glycopyrronium is a novel LAMA, currently in development for COPD. Phase II studies have shown that glycopyrronium 50 μg once daily provides clinically significant 24-hour bronchodilation with a rapid onset of action, which is faster than that of tiotropium, and a favorable safety and tolerability profile. The Phase III GLycopyrronium bromide in COPD airWays (GLOW) progr…
The Effect of Different High-Intensity Periodization Models on Endurance Adaptations
2016
Purpose: This study aimed to compare the effects of three different high-intensity training (HIT) models, balanced for total load but differing in training plan progression, on endurance adaptations. Methods: Sixty-three cyclists (peak oxygen uptake (V˙O2peak) 61.3 ± 5.8 mL·kg−1·min−1) were randomized to three training groups and instructed to follow a 12-wk training program consisting of 24 interval sessions, a high volume of low-intensity training, and laboratory testing. The increasing HIT group (n = 23) performed interval training as 4 × 16 min in weeks 1–4, 4 × 8 min in weeks 5–8, and 4 × 4 min in weeks 9–12. The decreasing HIT group (n = 20) performed interval sessions in the opposite…