Search results for " Individual"

P2-283: Dose individualization of Carboplatin in elderly patients with advanced non small cell lung cancer (ANSCLC): an exploratory analysis

2007

Monoclonal antibodies in gastrointestinal cancers

2013

Introduction: Among gastrointestinal cancers, colorectal and gastric neoplasms are the most frequent. The development of new targeted drugs improved the efficacy of systemic therapy in advanced stages of those malignancies. Areas covered: This review highlights the main biological processes implicated in gastrointestinal cancer development and progression, such as angiogenesis and epidermal growth factor receptor (EGFR) signaling pathway. On these bases, anti-EGFR and anti-vascular endothelial growth factor (VEGF) monoclonal antibodies in colorectal and gastric cancer are discussed. Data about further monoclonal antibodies in development are also reported. Expert opinion: The use of monoclo…

Erratum: Bosch-Sierra, N., et al. Effect of Fibre-Enriched Orange Juice on Postprandial Glycaemic Response and Satiety in Healthy Individuals: An Acu…

2021

The authors have requested that the following changes be made to their paper [...]

Spin up and phase fluctuations in the timing of the accreting millisecond pulsar XTE J1807-294

2007

We performed a timing analysis of the 2003 outburst of the accreting X-ray millisecond pulsar XTE J1807-294 observed by RXTE. Using recently refined orbital parameters we report for the first time a precise estimate of the spin frequency and of the spin frequency derivative. The phase delays of the pulse profile show a strong erratic behavior superposed to what appears as a global spin-up trend. The erratic behavior of the pulse phases is strongly related to rapid variations of the light curve, making it very difficult to fit these phase delays with a simple law. As in previous cases, we have therefore analyzed separately the phase delays of the first harmonic and of the second harmonic of …

Secular spin-down of the AMP XTE J1751-305

2011

Context. Of the 13 known accreting millisecond pulsars, only a few showed more than one outburst during the RXTE era. XTE J1751-305 showed, after the main outburst in 2002, other three dim outbursts. We report on the timing analysis of the latest one, occurred on October 8, 2009 and serendipitously observed from its very beginning by RXTE. Aims. The detection of the pulsation during more than one outburst permits to obtain a better constraint of the orbital parameters and their evolution as well as to track the secular spin frequency evolution of the source. Methods. Using the RXTE data of the last outburst of the AMP XTE J1751-305, we performed a timing analysis to improve the orbital para…

Timing of the accreting millisecond pulsar IGR~J17511--3057

2010

{Timing analysis of Accretion-powered Millisecond Pulsars (AMPs) is a powerful tool to probe the physics of compact objects. The recently discovered \newigrj is the 12 discovered out of the 13 AMPs known. The Rossi XTE satellite provided an extensive coverage of the 25 days-long observation of the source outburst.} {Our goal is to investigate the complex interaction between the neutron star magnetic field and the accretion disk, determining the angular momentum exchange between them. The presence of a millisecond coherent flux modulation allows us to investigate such interaction from the study of pulse arrival times. In order to separate the neutron star proper spin frequency variations fro…

Precise determination of orbital parameters in system with slowly drifting phases: application to the case of XTE J1807-294

2007

We describe a timing technique that allows to obtain precise orbital parameters of an accreting millisecond pulsar in those cases in which intrinsic variations of the phase delays (caused e.g. by proper variation of the spin frequency) with characteristic timescale longer than the orbital period do not allow to fit the orbital parameters over a long observation (tens of days). We show under which conditions this method can be applied and show the results obtained applying this method to the 2003 outburst observed by RXTE of the accreting millisecond pulsar XTE J1807-294 which shows in its phase delays a non-negligible erratic behavior. We refined the orbital parameters of XTE J1807-294 usin…

Recovery during the weekend and fluctuations in weekly job performance : a week-level study examining intra-individual relationships

2010

For most employees, the weekend offers the opportunity to recover and unwind from demands faced during the working week. In this study, first, we examined which factors contribute to employees' successful recovery during the weekend. Second, we investigated if being highly recovered after the weekend benefits different dimensions of job performance during the week. Using a within-person design we conducted a week-level study with 133 employees over four working weeks. Participants responded to weekly web-based surveys at the beginning and at the end of the working week. Hierarchical linear modelling showed that psychological detachment, relaxation, and mastery experiences during the weekend…

Investigating activity of masticatory muscles in patients with hypermobile temporomandibular joints by using EMG

2014

Background: Temporomandibular joint hypermobility (TMJH) can manifest higher range of motions in mandible. The aim of this study was to investigate and compare the activity of masticatory muscle of TMJs in healthy individuals and patients with mild, moderate and severe TMJH. Material and Methods: In this clinical study, 69 patients (between the ages of 22 to 42) with manifestation of TMJH were included. The patients were divided into three groups based on their maximum mouth opening (MMO): (light) with MMO of 50-55 mm; (moderate) with MMO between 55 to 65 mm; and (severe) with MMO >65 mm. Also, 20 healthy people with profiled tomography in the last 6 months were invited as control group (he…

Multiperiodic pulsations in the Be stars NW Serpentis and V1446 Aquilae

2007

Aims.We present accurate photometric time series of two Be stars: NW Ser and V1446 Aql . Both stars were observed at the Observatorio de Sierra Nevada (Granada) in July 2003 with an automatic four-channel Strömgren photometer. We also present a preliminary theoretical study showing that the periodic variations exhibited by these stars can be due to pulsation. Methods.An exhaustive Fourier analysis together with a least-square fitting has been carried out on the time series for all four Strömgren bands. Several independent frequencies and non-periodic trends explain most of the variance. A theoretical non-adiabatic code applied to stellar models for these stars shows that g-modes are unstabl…