Search results for " Intensity-Modulated"

showing 10 items of 26 documents

Acute and late toxicity and preliminary outcomes report of moderately hypofractionated helical tomotherapy for localized prostate cancer: a mono-inst…

2019

Aims: To assess toxicity and clinical outcomes of moderately hypofractionated helical tomotherapy (HT) for the curative treatment of localized prostate cancer (PC). Methods: From December 2012 to May 2018, 170 patients were treated with definitive intent for PC. Thirty-four percent were low risk, 30% intermediate risk (IR) and 36% high risk (HR). All patients received 70 Gy in 28 fractions to the prostate; 61.6 Gy were delivered to the seminal vesicles for IR; pelvic lymph nodes irradiation for a total dose of 50.4 Gy was added in the HR subgroup. Toxicity was assessed using CTCAE V4.0, and biochemical failure was defined following Phoenix criteria. Time-to-event data were analyzed using th…

MaleOrgans at Riskmedicine.medical_specialtymedicine.medical_treatmentKaplan-Meier EstimateAdenocarcinomaGastroenterologyTomotherapy030218 nuclear medicine & medical imaging03 medical and health sciencesProstate cancer0302 clinical medicineRetrospective StudieProstateInternal medicinemedicineHumansRadiology Nuclear Medicine and imagingRetrospective StudiesAgedAged 80 and overProstate cancerRadiotherapybusiness.industryIncidence (epidemiology)Prostatic NeoplasmsGeneral MedicineMiddle Agedmedicine.diseaseAcute toxicityRadiation therapymedicine.anatomical_structure030220 oncology & carcinogenesisProstatic NeoplasmToxicityQuality of LifeHypofractionationAdenocarcinomaRadiation Dose HypofractionationRadiotherapy Intensity-ModulatedbusinessHumanLa radiologia medica
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External photon radiation treatment for prostate cancer: Uncomplicated and cancer-free control probability assessment of 36 plans

2019

[Purpose] To perform a systematic and thorough assessment, using the Uncomplicated and Cancer-Free Control Probability (UCFCP) function, of a broad range of photon prostate cancer RT treatments, on the same scenario (a unique pelvic CT set). UCFCP considers, together with the probabilities of local tumour control (TCP) and deterministic (late) sequelae (NTCP), the second primary cancer risk (SPCR) due to photon and neutron peripheral doses.

MaleProbability assessmentmedicine.medical_treatmentRadiobiological modellingBiophysicsGeneral Physics and AstronomyProstate radiotherapy treatmentNormal tissue complication probabilityTumour control probabilityRadiation protection of the patient030218 nuclear medicine & medical imaging03 medical and health sciencesProstate cancer0302 clinical medicinemedicineHumansDosimetryRadiology Nuclear Medicine and imagingConformal radiationProbabilityPhotonsbusiness.industryRadiotherapy Planning Computer-AssistedCancer-FreePhoton radiationProstatic NeoplasmsRadiotherapy DosageGeneral MedicineSecond primary cancermedicine.diseaseRadiation therapySecond primary cancer risk030220 oncology & carcinogenesisRadiotherapy plan optimisationRadiotherapy Intensity-ModulatedRadiotherapy ConformalTomography X-Ray ComputedNuclear medicinebusinessPhysica Medica 66: 88-96 (2019)
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Salvage reirradiation for locoregional failure after radiation therapy for prostate cancer: Who, when, where and how?

2014

Even in the current era of dose-escalated radiotherapy for prostate cancer, biochemical recurrence is not uncommon. Furthermore, biochemical failure is not specific to the site of recurrence. One of the major challenges in the management of prostate cancer patients with biochemical failure after radiotherapy is the early discrimination between those with locoregional recurrence only and those with metastatic disease. While the latter are generally considered incurable, patients with locoregional disease may benefit from emerging treatment options. Ultimately, the objective of salvage therapy is to control disease while ensuring minimal collateral damage, thereby optimizing both cancer and t…

MaleQuality ControlOncologyBiochemical recurrencemedicine.medical_specialtyAntineoplastic Agents Hormonalmedicine.medical_treatmentBrachytherapyBrachytherapySalvage therapyBone Neoplasms[SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicineAdenocarcinomaRadiosurgeryMultimodal Imaging[ SDV.IB.MN ] Life Sciences [q-bio]/Bioengineering/Nuclear medicineManagement of prostate cancerProstate cancerInternal medicinemedicineHumansMulticenter Studies as TopicRadiology Nuclear Medicine and imagingComputingMilieux_MISCELLANEOUSProstatectomySalvage TherapyLymphatic Irradiationbusiness.industryPalliative CareProstatic NeoplasmsCancerAndrogen AntagonistsRadiotherapy DosageProstate-Specific Antigenmedicine.diseaseCombined Modality Therapy3. Good healthRadiation therapyProstate-specific antigenOncologyLymphatic MetastasisDose Fractionation RadiationRadiotherapy Intensity-ModulatedNeoplasm Recurrence LocalbusinessRadiotherapy Image-Guided
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Chemo-radiotherapy induced oral mucositis during IMRT for head and neck cancer: an assessment

2014

Background This study is conducted mainly to evaluate the changes in quality and quantity of oral epithelial cells during the course of IMRT. Material and Methods 30 Patients undergoing chemo-radiotherapy were followed through course of treatment. They were compared with a group of age- and sex-matched healthy individuals. The procedure involved WHO clinical scoring, collection of oral washings and preparation of buccal smears from both study group and control group. The changes occurred were recorded as a way of assessing the severity of oral mucositis. Results Revealed a significant occurrence of oral mucositis in almost all patients during weekly follow up. There was a significant increa…

Malemedicine.medical_specialtyCell SurvivalMucosal cellAntineoplastic AgentsOdontologíaCellular levelGastroenterologyInternal medicinemedicineMucositisHumansGeneral DentistryStomatitisChemo-radiotherapyStomatitisOral Medicine and Pathologybusiness.industryResearchHead and neck cancerEpithelial CellsBuccal administrationmedicine.disease:CIENCIAS MÉDICAS [UNESCO]Ciencias de la saludSurgerystomatognathic diseasesOtorhinolaryngologyHead and Neck NeoplasmsHealthy individualsUNESCO::CIENCIAS MÉDICASSurgeryFemaleRadiotherapy Intensity-Modulatedbusiness
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Impact of 18F-Choline PET/CT in the Decision-Making Strategy of Treatment Volumes in Definitive Prostate Cancer Volumetric Modulated Radiation Therapy

2015

INTRODUCTION Aim of the study is to evaluate the impact of Cho-PET/CT in decision-making strategy of patients with localized prostate cancer (PC) eligible to definitive radiotherapy (RT). MATERIALS AND METHODS Sixty patients Cho-PET/CT before RT were prospectively enrolled. All patients were treated with volumetric modulated arc therapy with simultaneous integrated boost in 28 fractions. Androgen deprivation therapy was prescribed according to National Comprehensive Cancer Network (NCCN) risk classification. Therapeutic strategy based on the Cho-PET/CT evaluation was compared with the strategy that would have been proposed in case of PET not available and/or not strictly indicated, accordin…

Malemedicine.medical_specialtyRadical treatmentmedicine.medical_treatmentClinical Decision-Making18F-cholineMultimodal ImagingCholineAndrogen deprivation therapyProstate cancerProstateNuclear Medicine and ImagingIntensity-ModulatedMedicineHumansRadiology Nuclear Medicine and imagingRadiation treatment planningTomographyAgedPET-CTProstate cancerRadiotherapybusiness.industryCancerProstatic NeoplasmsGeneral MedicineMiddle Agedmedicine.diseaseX-Ray ComputedRadiation therapymedicine.anatomical_structurePositron-Emission TomographyRadiologyCho-PET/CT; Prostate cancer; Radical treatment; Radiotherapy; Aged; Choline; Humans; Male; Middle Aged; Multimodal Imaging; Prostatic Neoplasms; Radiopharmaceuticals; Clinical Decision-Making; Positron-Emission Tomography; Radiotherapy Intensity-Modulated; Tomography X-Ray Computed; Radiology Nuclear Medicine and ImagingRadiotherapy Intensity-ModulatedRadiopharmaceuticalsbusinessNuclear medicineRadiologyTomography X-Ray ComputedCho-PET/CT
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Dose–volume-related dysphagia after constrictor muscles definition in head and neck cancer intensity-modulated radiation treatment

2014

Dysphagia remains a side effect influencing the quality of life of patients with head and neck cancer (HNC) after radiotherapy. We evaluated the relationship between planned dose involvement and acute and late dysphagia in patients with HNC treated with intensity-modulated radiation therapy (IMRT), after a recontouring of constrictor muscles (PCs) and the cricopharyngeal muscle (CM).Between December 2011 and December 2013, 56 patients with histologically proven HNC were treated with IMRT or volumetric-modulated arc therapy. The PCs and CM were recontoured. Correlations between acute and late toxicity and dosimetric parameters were evaluated. End points were analysed using univariate logisti…

Malemedicine.medical_specialtySide effectmedicine.medical_treatmentYoung AdultPlanned DoseSwallowingNuclear Medicine and ImagingIntensity-Modulated80 and overotorhinolaryngologic diseasesHumansMedicineRadiology Nuclear Medicine and imagingTomographyAgedRetrospective StudiesAged 80 and overFull PaperAged; Aged 80 and over; Deglutition; Deglutition Disorders; Female; Follow-Up Studies; Head and Neck Neoplasms; Humans; Laryngeal Muscles; Male; Middle Aged; Quality of Life; Radiotherapy Dosage; Radiotherapy Intensity-Modulated; Retrospective Studies; Tomography X-Ray Computed; Young Adult; Radiology Nuclear Medicine and ImagingRadiotherapybusiness.industryHead and neck cancerRadiotherapy DosageRetrospective cohort studyGeneral MedicineMiddle Agedmedicine.diseaseDysphagiaAcute toxicityDeglutitionX-Ray ComputedSurgeryRadiation therapyHead and Neck NeoplasmsQuality of LifeFemaleRadiotherapy Intensity-ModulatedRadiologyLaryngeal Musclesmedicine.symptomTomography X-Ray ComputedDeglutition DisordersRadiologybusinessFollow-Up StudiesThe British Journal of Radiology
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Moderate hypofractionated helical tomotherapy for prostate cancer in a cohort of older patients: a mono-institutional report of toxicity and clinical…

2019

Purpose or objective: To evaluate toxicity and outcomes of moderately hypofractionated helical tomotherapy for the curative treatment of a cohort of patients aged ≥ 75 years with localized prostate cancer (PC). Materials and methods: From January 2013 to February 2017, 95 patients with median age 77 years (range 75–88) were treated for PC. 39% were low risk, 33% intermediate risk (IR), 28% high risk (HR). Median iPSA was 9.42 ng/ml (1.6–107). Androgen deprivation was prescribed according to NCCN recommendations. All patients received 70 Gy in 28 fractions to the prostate; 61.6 Gy were delivered to the seminal vesicles for IR; whole pelvis irradiation with a total dose of 50.4 Gy was added i…

OncologyMaleAgingmedicine.medical_specialtymedicine.medical_treatmentTomotherapyCohort Studies03 medical and health sciencesProstate cancer0302 clinical medicineQuality of lifeStatistical significanceInternal medicinemedicineHumans030212 general & internal medicineAgedAged 80 and overbusiness.industryProstatic NeoplasmsAndrogen AntagonistsMiddle Agedprostate cancermedicine.diseaseRadiation therapyTreatment OutcomeToxicityCohortQuality of LifeRadiotherapy Intensity-ModulatedGeriatrics and Gerontologybusiness030217 neurology & neurosurgeryCohort studyAging clinical and experimental research
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Absolute volume of the rectum and AUC from rectal DVH between 25Gy and 50Gy predict acute gastrointestinal toxicity with IG-IMRT in prostate cancer

2016

International audience; Background: To determine whether dose/volume specific endpoints (DVSE) or Area under the rectal DVH curve (rAUC) better predict acute gastrointestinal (GI) toxicity in prostate cancer patients treated with IMRT in the era of daily image guidance (IG-IMRT). Methods: A set of DVSE was recorded from V25 to V75 (increments of 5Gy) (both in % and in cc) for 180 men. The rAUC was calculated for doses ranging between 25Gy and 50Gy (rAUC(25-50)). Univariate and multivariate logistic regressions were performed to determine the relationship between DVSE or rAUC(25-50) and the appearance of any acute GI toxicity. Results: The rates of acute grade 1 (G1), G2 and G3 GI toxicities…

OncologyMale[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imagingmedicine.medical_treatmentGastroenterology030218 nuclear medicine & medical imaging[ SDV.CAN ] Life Sciences [q-bio]/Cancer[ SDV.IB.MN ] Life Sciences [q-bio]/Bioengineering/Nuclear medicineProstate cancer0302 clinical medicineProstateLarge intestineConformal Radiation-Therapy[ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/ImagingAged 80 and overGastrointestinal tractProstate cancerRadiotherapy DosageMiddle Aged3. Good healthmedicine.anatomical_structureImpactOncologyRadiology Nuclear Medicine and imaging030220 oncology & carcinogenesisArea Under CurveToxicityImage Guidancemedicine.medical_specialtyRectum[SDV.CAN]Life Sciences [q-bio]/Cancer[SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine03 medical and health sciencesInternal medicinemedicineBiochemical ControlHumansRadiology Nuclear Medicine and imagingRadiation InjuriesAgedRadiotherapybusiness.industryResearchRectumProstatic Neoplasmsmedicine.diseaseRadiation therapyAcute rectal toxicity predictive factorLogistic ModelsRadiotherapy Intensity-ModulatedbusinessAbsolute volumeRadiation Oncology (London, England)
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Intensity modulated radiation therapy with simultaneous integrated boost in early breast cancer irradiation. Report of feasibility and preliminary to…

2015

To investigate the feasibility and tolerance in the use of adjuvant intensity modulated radiation therapy (IMRT) and simultaneous integrated boost in patients with a diagnosis of breast cancer after breast-conserving surgery.Between September 2011 to February 2013, 112 women with a diagnosis of early breast cancer (T1-2, N0-1, M0) were treated with IMRT and simultaneous integrated boost after breast-conserving surgery in our institution. A dose of 50Gy in 25 fractions was prescribed to the whole breast and an additional dose of radiation was prescribed on the tumour bed. A dose prescription of 60Gy in 25 fractions to the tumour bed was used in patients with negative margins after surgery, w…

Oncologymedicine.medical_treatmentSegmentalMastectomy SegmentalSeverity of Illness IndexBreast cancerNuclear Medicine and ImagingDuctalIntensity-Modulated80 and overBreastMastectomyAdjuvantEarly breast cancerAged 80 and overCarcinoma Ductal BreastSIBRadiotherapy DosageMiddle AgedOncologyBreast cancer; IMRT; SIB; Toxicity; Adult; Aged; Aged 80 and over; Breast Neoplasms; Carcinoma Ductal Breast; Carcinoma Lobular; Esthetics; Feasibility Studies; Female; Follow-Up Studies; Humans; Mastectomy Segmental; Middle Aged; Radiodermatitis; Radiotherapy Dosage; Radiotherapy Adjuvant; Severity of Illness Index; Radiotherapy Intensity-Modulated; Oncology; Radiology Nuclear Medicine and ImagingToxicityFemaleRadiologyRadiodermatitisRadiologyAdjuvantSimultaneous integrated boostAdultmedicine.medical_specialtyEstheticsBreast NeoplasmsLobularBreast cancerInternal medicineSeverity of illnessmedicineHumansRadiology Nuclear Medicine and imagingIMRTAgedToxicityRadiotherapybusiness.industryCarcinomaIntensity-modulated radiation therapymedicine.diseaseAcute toxicityBreast cancer; IMRT; SIB; Toxicity; Oncology; Radiology Nuclear Medicine and ImagingCarcinoma LobularFeasibility StudiesRadiotherapy AdjuvantRadiotherapy Intensity-ModulatedbusinessFollow-Up Studies
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Investigation of correction factors for non-reference conditions in ion chamber photon dosimetry with Monte-Carlo simulations.

2009

Current dosimetry protocols require geometrical reference conditions for the determination of absorbed dose in external radiotherapy. Whenever these geometrical conditions cannot be maintained the application of additional corrections becomes necessary, in principle. The current DIN6800-2 protocol includes a corresponding factor k(NR), but numerical values are lacking and no definite information about the magnitude of this correction is available yet. This study presents Monte-Carlo based calculations within the 6 MV-X photon field of a linear accelerator for a common used ion chamber (PTW31010) employing the EGSnrc code system. The linear accelerator model was matched to measurements, show…

PhotonMonte Carlo methodBiophysicsRadiation DosageLinear particle acceleratorlaw.inventionIonlawDosimetryHumansScattering RadiationRadiology Nuclear Medicine and imagingPhysicsIonsPhotonsRadiological and Ultrasound TechnologyPhantoms ImagingRadiotherapy Planning Computer-AssistedReproducibility of ResultsWaterParticle acceleratorCharged particleIonization chamberRadiotherapy Intensity-ModulatedAtomic physicsParticle AcceleratorsMonte Carlo MethodAlgorithmsZeitschrift fur medizinische Physik
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