6533b833fe1ef96bd129b98e

RESEARCH PRODUCT

Chemo-radiotherapy induced oral mucositis during IMRT for head and neck cancer: an assessment

Karthika Nagarajan

subject

Malemedicine.medical_specialtyCell SurvivalMucosal cellAntineoplastic AgentsOdontologíaCellular levelGastroenterologyInternal medicinemedicineMucositisHumansGeneral DentistryStomatitisChemo-radiotherapyStomatitisOral Medicine and Pathologybusiness.industryResearchHead and neck cancerEpithelial CellsBuccal administrationmedicine.disease:CIENCIAS MÉDICAS [UNESCO]Ciencias de la saludSurgerystomatognathic diseasesOtorhinolaryngologyHead and Neck NeoplasmsHealthy individualsUNESCO::CIENCIAS MÉDICASSurgeryFemaleRadiotherapy Intensity-Modulatedbusiness

description

Background This study is conducted mainly to evaluate the changes in quality and quantity of oral epithelial cells during the course of IMRT. Material and Methods 30 Patients undergoing chemo-radiotherapy were followed through course of treatment. They were compared with a group of age- and sex-matched healthy individuals. The procedure involved WHO clinical scoring, collection of oral washings and preparation of buccal smears from both study group and control group. The changes occurred were recorded as a way of assessing the severity of oral mucositis. Results Revealed a significant occurrence of oral mucositis in almost all patients during weekly follow up. There was a significant increase in percentage of viable buccal epithelial cells in study group when compared to normal controls (P<0.005) during and at the end of chemo-radiotherapy. Conclusions Quantification of oral mucositis can be done at cellular level by determining the oral mucosal cell viability and their maturation during IMRT. Key words:Oral mucositis, in vitro assay, quantification, radiotherapy, chemotherapy, viable cells.

yearjournalcountryeditionlanguage
2014-04-23
http://hdl.handle.net/10550/45049