Search results for " Interference"

Diffractive optics for processing ultrashort light pulses

2011

In this work we combine, in principle, two disjoint optical fields, diffractive optics and ultrashort light radiation. This combination allows us to manipulate in a very unconventional manner femtosecond pulses and, on the other hand, to implement a set of novel applications. In our case we have focused our attention on material processing and biophotonics applications.

Analytical Evaluation of the Temporal Focal Shift for Arbitrary Pulse Shapes

2004

In this letter, we analyze the propagation of linearly chirped arbitrary-shaped light pulses through a parabolic dispersive medium to derive an analytical formula of assessing the location of the transverse plane where the pulse root-mean-square width is minimum. Closed form expressions for compressed pulses, which are independent of the input pulse shape, are demonstrated. In this way, we demonstrate that both the relative temporal focal shift and the minimum pulsewidth are solely determined by two factors, the temporal equivalent of the Fresnel number of the geometry and the pulse quality factor, i.e., the temporal analogue of the spatial M/sup 2/ beam quality factor. Some examples are di…

Grating compensated dispersion-managed systems incorporating nonlinear optical loop mirrors

2006

In this work, we investigate the use of nonlinear optical loop mirrors (NOLMs) in DM fiber systems compensated by CFGs with GDR by launching a 128-bit Gaussian-shaped pseudo-random bit sequence having pulse width of 5 ps for simulating a 40 Gb/s system. The dispersion map contains a fiber segment of length 10.3 km and a CFG with dispersion of -15.6 ps/nm. We consider a lossless grating and the GDR is modeled by a sinusoidal function for simplicity. We have shown that the use of NOLMs can substantially improve the transmission performance in a grating-compensated DM fiber system even with presence of amplifier noise and random variations of GDR, parameters in CFGs along the propagation dista…

NTD-GE-based microcalorimeter performance

2000

Our group has been developing x-ray microcalorimeters consisting of neutron transmutation doped (NTD) germanium thermistors attached to superconducting tin absorbers. We discuss the performance of single pixel x-ray detectors, and describe an array technology. In this paper we describe the read-out circuit that allows us to measure fast signals in our detectors as this will be important in understanding the primary cause of resolution broadening. We describe briefly a multiplexing scheme that allows a number of different calorimeters to be read out using a single JFET. We list the possible causes of broadening and give a description of the experiment which best demonstrates the cause of the…

Readout of quantum information spreading using a disordered quantum walk

2021

We design a quantum probing protocol using quantum walks to investigate the quantum information spreading pattern. We employ quantum Fisher information as a figure of merit to quantify extractable information about an unknown parameter encoded within the quantum walk evolution. Although the approach is universal, we focus on the coherent static and dynamic disorder to investigate anomalous and classical transport as well as Anderson localization. We provide a feasible experimental strategy to implement, in principle, the quantum probing protocol based on the quantum Fisher information using a Mach–Zehnder-like interferometric setup. Our results show that a quantum walk can be considered as …

Gaussian pulse propagation in dispersion-managed systems using chirped fiber gratings with group delay ripples

2005

We study the propagation of Gaussian-shaped pulses in grating-compensated dispersion-managed systems with group delay ripples (GDR). We show that the intersymbol interference caused by the GDR in gratings can be substantially reduced by nonlinear optical loop mirrors and the 40-Gb/s system performance can achieve transoceanic transmission in the presence of amplifier noise and random variations in ripple period of the gratings along the transmission line.

Gata4 Blocks Somatic Cell Reprogramming By Directly Repressing Nanog

2012

Abstract Somatic cells can be reprogrammed to induced pluripotent stem (iPS) cells by ectopic expression of the four factors Oct4, Klf4, Sox2, and Myc. Here, we investigated the role of Gata4 in the reprogramming process and present evidence for a negative role of this family of transcription factors in the induction of pluripotency. Coexpression of Gata4 with Oct4, Klf4, and Sox2 with or without Myc in mouse embryonic fibroblasts greatly impaired reprogramming and endogenous Nanog expression. The lack of Nanog upregulation was associated with a blockade in the transition from the initiation phase of reprogramming to the full pluripotent state characteristic of iPS cells. Addition of Nanog …

α-Mannosyl-Functionalized Cationic Nanohydrogel Particles for Targeted Gene Knockdown in Immunosuppressive Macrophages

2019

Immunosuppressive M2 macrophages govern the immunophathogenic micromilieu in many severe diseases including cancer or fibrosis, thus, their re-polarization through RNA interference is a promising concept to support combinatorial therapies. For targeted siRNA delivery, however, safe and stable carriers are required that manage cell specific transport to M2 macrophages. Here, siRNA-loaded cationic nanogels are reported with α-mannosyl decorated surfaces that target and modify M2 macrophages selectively. Via amphiphilic precursor block copolymers bearing one single α-mannosyl moiety at their chain end mannosylated cationic nanohydrogel particles (ManNP) were obtained of 20 nm diameter determin…

From Polymers to Functional Biomaterials.

2017

SiRNA-mediated in vivo gene knockdown by acid-degradable cationic nanohydrogel particles

2017

Cationic nanohydrogel particles have become an attractive tool for systemic siRNA delivery, but improvement of their in vivo tolerance is desirable, especially to prevent potential long term side effects by tissue and cellular accumulation. Here, we designed novel ketal cross-linked cationic nanohydrogel particles that were assessed for reduced tissue accumulation and robust siRNA delivery in vitro and in vivo. An oligo-amine cross-linker equipped with a ketal moiety in its core was synthesized and applied to nanohydrogel cross-linking of self-assembled reactive ester block copolymers in DMSO. The resulting acid-sensitive cationic nanoparticles spontaneously disassembled over time in acidic…