Search results for " Interference"
showing 10 items of 340 documents
Neuronal inhibition of the autophagy nucleation complex extends lifespan in post-reproductive C. elegans
2017
AbstractAutophagy is a ubiquitous catabolic process, which causes cellular bulk degradation of cytoplasmic components and thereby regulates cellular homeostasis. Inactivation of autophagy has been linked with detrimental effects to cells and organisms. The antagonistic pleiotropy theory postulates that fitness promoting genes during youth are harmful during aging (Williams 1957). On this basis we examined genes mediating post-reproductive longevity using an RNA interference screen. From this screen we identified 30 novel regulators of post-reproductive longevity including pha-4. Through downstream analysis of pha-4 we identify that genes governing the early stages of autophagy up until the …
The Causal Influence of Life Meaning on Weight and Shape Concerns in Women at Risk for Developing an Eating Disorder
2021
Background: Although previous studies have shown an inverse relation between life meaning and eating disorder symptoms, the correlational nature of this evidence precludes causal inferences. Therefore, this study used an experimental approach to test the causal impact of life meaning on individuals' weight and shape concerns.Methods: Female students at risk for developing an eating disorder (N = 128) were randomly assigned to the control or the meaning condition, which involved thinking about and committing to pursue intrinsically valued life goals. A color-naming interference task was used to assess the motivational salience of body-related stimuli, and self-report measures were used to as…
El fundamento liberal del derecho a la intimidad
2021
T: The right to privacy is configured as a ?retaining wall? against State interference into the private sphere of people?s life. Throughout this work we will try to expose the philosophical-liberal foundations that have led us to what is now conceived as the ?right to privacy?.
Influence of stimulus color on the control of reaching-grasping movements.
2001
This kinematic study aimed to determine whether color is a stimulus property involved in the control of reaching-grasping movements. Subjects reached and grasped a target-object, located either on the right or on the left of the subject's midline. A distractor, placed along the subject's midline, could be randomly presented. The colors, i.e., both chromaticity (red and green stimuli were presented) and lightness, of the target and distractor were varied in experiment 1. Only stimulus lightness and only stimulus chromaticity were varied in experiments 2 and 3, respectively. In experiment 4 subjects matched with their thumb and index finger the size of the target-stimuli presented in experime…
Endonasal Sinus Surgery Improves Mucociliary Transport in Severe Chronic Sinusitis
1997
A total of 22 patients with extensive chronic sinusitis were examined before and 7.2 ± 1.1 months after microscopic endonasal sinus surgery. Pre- and postoperative nasal mucociliary transport was measured using a modified saccharine test and ciliary beat frequency of nasal respiratory cells using video interference contrast microscopy. In patients suffering from chronic sinusitis, nasal ciliary beat frequency was significantly lower (8.0 ± 1.8 Hz) than in normals (9.5 ± 1.7 Hz, p < 0.02). Following endonasal sinus surgery, ciliary beat frequency in patients with chronic sinusitis remained reduced (8.3 ± 1.2 Hz). Nasal mucociliary transport time was significantly (p < 0.05) longer (20…
Stroop task performance across the lifespan: High cognitive reserve in older age is associated with enhanced proactive and reactive interference cont…
2020
Abstract Susceptibility to interference increases with age but there is large inter-individual variability in interference control in older adults due to a number of biological and environmental factors. The present study aims at analyzing behavior and ERPs in a Stroop interference task with increasing difficulty in a sample of 246 young, middle-aged and healthy old participants. The old age group was divided into three subgroups based on performance scores. The results show a gradual performance reduction with increasing age and task difficulty. However, old high performers reached a performance level comparable to middle-aged subjects. The contingent negative variation (CNV) reflecting pr…
Qualitative different memory impairments across frontal lobe subgroups
2006
Recall impairments in patients with lesions to the prefrontal cortex (PFC) have variously been attributed to problems with organisation at encoding, organisation at retrieval and monitoring at retrieval. Neuroimaging and recent theoretical work has associated the left lateral PFC with organisation and strategy production at encoding, and the right lateral PFC with organisation, error detection and monitoring at retrieval. However few lesion studies have been anatomically specific enough to test the direct predictions made by this work. Proactive interference, response to prompting, monitoring and organisational strategies were examined in 34 patients with frontal lobe lesions and 50 healthy…
Effects of endurance training only versus same-session combined endurance and strength training on physical performance and serum hormone concentrati…
2014
This study investigated the effects of endurance training only (E, n = 14) and same-session combined training, when strength training is repeatedly preceded by endurance loading (endurance and strength training (E+S), n = 13) on endurance (1000-m running time during incremental field test) and strength performance (1-repetition maximum (1RM) in dynamic leg press), basal serum hormone concentrations, and endurance loading-induced force and hormone responses in recreationally endurance-trained men. E was identical in the 2 groups and consisted of steady-state and interval running, 4–6 times per week for 24 weeks. E+S performed additional mixed-maximal and explosive-strength training (2 times…
RNA2-encoded VP37 protein of Broad bean wilt virus 1 is a determinant of pathogenicity, host susceptibility, and a suppressor of post-transcriptional…
2020
Abstract Broad bean wilt virus 1 (BBWV‐1, genus Fabavirus, family Secoviridae) is a bipartite, single‐stranded positive‐sense RNA virus infecting many horticultural and ornamental crops worldwide. RNA1 encodes proteins involved in viral replication whereas RNA2 encodes two coat proteins (the large and small coat proteins) and two putative movement proteins (MPs) of different sizes with overlapping C‐terminal regions. In this work, we determined the role played by the small putative BBWV‐1 MP (VP37) on virus pathogenicity, host specificity, and suppression of post‐transcriptional gene silencing (PTGS). We engineered a BBWV‐1 35S‐driven full‐length cDNA infectious clone corresponding to BBWV‐…
MicroRNAs as Novel Targets in Liver Cancer: Facing the Clinical Challenge
2014
Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths worldwide with a rising incidence in the western world. HCCs are characterized by a phenotypic and molecular heterogeneity that limits therapeutic progress. MicroRNAs play a major role for the pathogenesis and progression of liver cancer. As an essential part of the RNA interference machinery, microRNAs contribute to the regulation of many pro-oncogenic processes in HCC, including proliferation, migration, and survival. Therefore, these epigenetically active small molecules advanced to attractive targets for both diagnosis and therapy of liver cancer. Here, we will try to delineate the role of microRNAs during liver de…