Search results for " J. M"
showing 10 items of 55 documents
Sodium channels enable fast electrical signaling and regulate phagocytosis in the retinal pigment epithelium
2019
Background Voltage-gated sodium (Nav) channels have traditionally been considered a trademark of excitable cells. However, recent studies have shown the presence of Nav channels in several non-excitable cells, such as astrocytes and macrophages, demonstrating that the roles of these channels are more diverse than was previously thought. Despite the earlier discoveries, the presence of Nav channel-mediated currents in the cells of retinal pigment epithelium (RPE) has been dismissed as a cell culture artifact. We challenge this notion by investigating the presence and possible role of Nav channels in RPE both ex vivo and in vitro. Results Our work demonstrates that several subtypes of Nav cha…
Energy-loss straggling of 2-10 MeV/u Kr ions in gases
2013
Measurements have been performed on a time-of-flight setup at the Jyväskylä K130 cyclotron, aiming at energy-loss straggling of heavy ions in gases. Theoretical predictions based on recently developed theory as well as an empirical interpolation formula predict that straggling can be more than ten times higher than Bohr straggling in the MeV/u regime. Our measurements with up to 9.3 MeV/u Kr ions on He, N2, Ne and Kr targets confirm this feature. Our calculations show the relative contributions of linear straggling, bunching including packing, and charge exchange. Our results for stopping cross sections are compatible with values from the literature. Funding Agencies|EU||Academy of Finland …
Reactive Self-Assembly and Specific Cellular Delivery of NCO-sP(EO-stat-PO)-Derived Nanogels
2018
This study presents the reactive self-assembly of isocyanate functional and amphiphilic six-arm, star-shaped polyether prepolymers in water into nanogels. Intrinsic molecular amphiphilicity, mainly driven by the isophorone moiety at the distal endings of the star-shaped molecules, allows for the preparation of spherical particles with an adjustable size of 100-200 nm by self-assembly and subsequent covalent cross-linking without the need for organic solvents or surfactants. Covalent attachment of a fluorescence dye and either the cell-penetrating TAT peptide or a random control peptide sequence shows that only TAT-labeled nanogels are internalized by HeLa cells. The nanogels thus specifical…
Tunteiden kirjoa Nicaraguan auringon alla
2019
Kirja-arvostelu teoksesta Sergio Ramírez: Anteeksianto ja unohdus ja muita novelleja Koonnut ja suom. Jyrki Lappi-Seppälä. Aviador, 2019, 213 s. nonPeerReviewed
Hans J. Morgenthau´s Turn from International Law to International Relations: A transition affected by History
2018
Este texto aborda el papel que las consideraciones históricas desempeñaron en un movimiento teórico sustancial: el paso que a partir de los años cuarenta se produce desde el Derecho Internacional a las Relaciones Internacionales en tanto que principal disciplina ordenadora del ámbito interestatal. Se tomará a Hans J. Morgenthau como el ejemplo más claro de este movimiento. Al igual que tantos otros intelectuales europeos exiliados en Estados Unidos, el cambio de continente y de contexto académico implicará para Morgenthau el salto del estudio del Derecho al estudio de la Política. Para explicar este movimiento y, en concreto, el peso que la Historia tiene en él, se estructurará el artículo …
Bioactive glass ions induce efficient osteogenic differentiation of human adipose stem cells encapsulated in gellan gum and collagen type I hydrogels
2019
Abstract Background Due to unmet need for bone augmentation, our aim was to promote osteogenic differentiation of human adipose stem cells (hASCs) encapsulated in gellan gum (GG) or collagen type I (COL) hydrogels with bioactive glass (experimental glass 2-06 of composition [wt-%]: Na2O 12.1, K2O 14.0, CaO 19.8, P2O5 2.5, B2O3 1.6, SiO2 50.0) extract based osteogenic medium (BaG OM) for bone construct development. GG hydrogels were crosslinked with spermidine (GG-SPD) or BaG extract (GG-BaG). Methods Mechanical properties of cell-free GG-SPD, GG-BaG, and COL hydrogels were tested in osteogenic medium (OM) or BaG OM at 0, 14, and 21 d. Hydrogel embedded hASCs were cultured in OM or BaG OM fo…
Identifying yeasts using surface enhanced Raman spectroscopy
2019
Made available in DSpace on 2019-10-06T15:40:09Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-07-05 Tekes Academy of Finland Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) The molecular fingerprints of yeasts Saccharomyces cerevisiae, Dekkera bruxellensis, and Wickerhamomyces anomalus (former name Pichia anomala) have been examined using surface-enhanced Raman spectroscopy (SERS) and helium ion microscopy (HIM). The SERS spectra obtained from cell cultures (lysate and non-treated cells) distinguish between these very closely related fungal species. Highly SERS active silver nano-particles suitable for detecting complex biomolecules were fabricated using a simple synt…
Suolahden kadunnimet
2000
Henkilöiden väliset suhteet Muumilaakson yhteisössä : Tove Janssonin Muumipappa ja meri- ja Taikurin hattu -kirjoissa
2010
Hallittu tasa-arvo : sukupuolten välinen tasa-arvo ja argumentaatio kuntien tasa-arvosuunnitelmissa
2008
Tutkielman kohteena ovat kunnissa laaditut henkilöstöpoliittiset tasa-arvosuunnitelmat. Laki naisten ja miesten välisestä tasa-arvosta (Tasa-arvolaki) velvoittaa kaikki säännöllisesti yli 30 henkilöä työllistävät työpaikat laatimaan tasa-arvosuunnitelman, jonka tarkoitus on edistää tasa-arvoa. Tutkimuksen tehtävänä on selvittää retoriikka- ja tekstianalyysin avulla sitä, millaista tasa-arvoa aineiston tasa-arvosuunnitelmissa rakennetaan, millaisia argumentteja niissä esitetään ja pohtia näiden kautta sitä, millaisia tasa-arvopolitiikan instrumentteja suunnitelmat ovat – toteutuuko tasa-arvo suunnitelmilla. Aineistoni tasa-arvosuunnitelmat ovat tiukasti hallinnolliseen kontekstiinsa sidottuj…