Search results for " KAP"
showing 10 items of 266 documents
Differences in Kaposi sarcoma-associated herpesvirus-specific and herpesvirus-non-specific immune responses in classic Kaposi sarcoma cases and match…
2011
Kaposi sarcoma (KS) might develop because of incompetent immune responses, both non-specifically and specifically against the KS-associated herpesvirus (KSHV). Peripheral blood mononuclear cells from 15 classic (non-AIDS) KS cases, 13 KSHV seropositives (without KS) and 15 KSHV-seronegative controls were tested for interferon-γ T-cell (enzyme-linked immunospot [Elispot]) responses to KSHV-latency-associated nuclear antigen (LANA), KSHV-K8.1 and CMV/Epstein-Barr virus (EBV) peptide pools. The forearm and thigh of each participant was also tested for delayed-type hypersensitivity (DTH) against common recall antigens. Groups were compared with Fisher exact test and multinomial logistic regress…
Is measurement of the gingival biotype reliable? Agreement among different assessment methods.
2019
Background To determine agreement among the most commonly used methods for assessing the gingival biotype. Material and Methods An electronic survey was sent to a sample of dentists practicing in Spain. The questionnaire was based on the evaluation of 5 cases involving different gingival biotype assessment methods. Dentists were required to classify the cases as having a “thin”, “thick” or “not able to classify” biotype. Each case was assessed using a frontal intraoral photo of the anterior teeth; an enlarged photo of the buccal aspect of the tooth with a periodontal probe inserted inside the sulcus; and the real thickness measured in mm with a calibrated needle. Agreement among the classif…
Statement validity assessment: Inter-rater reliability of criteria-based content analysis in the mock-crime paradigm
2005
Methods. Three raters were trained in CBCA. Subsequently, they analysed transcripts of 102 statements referring to a simulated theft of money. Some of the statements were based on experience and some were confabulated. The raters used 4-point scales, respectively, to judge the degree to which 18 of the 19 CBCA criteria were fulfilled in each statement. Results. The analysis of rater judgment distributions revealed that, with judgments of individual raters varying only slightly across transcripts, the weighted kappa coefficient, the product-moment correlation, and the intra-class correlation were inadequate indices of reliability. The Finn-coefficient and percentage agreement, which were cal…
La construcción de la experiencia del viaje en la escritura: figuras del escritor viajero contemporáneo
2014
Resumen: El presente trabajo propone un análisis de la representación del viaje en las obras literarias contemporáneas. Se parte de la hipótesis de que existe una relación entre la experiencia del viaje y su representación en la literatura. El objetivo de este ejercicio crítico es explicar este vínculo, señalando la importancia de la escritura como un espacio en el que se construye la experiencia del viaje. Palabras Clave: Guevara, Armada, Reverte, Kerouac, Chatwin, Krakauer, Kapucinski, viaje, transformación del sujeto, conocimiento, metaliteratura, intertextualidad. Abstract: This article proposes an analysis of the representation of the journey in contemporary literature. It’s assume…
Ilgtspējīgas attīstības sociālā dimensija un sociālā inovācija: tēžu krājums
2016
SUSTINNO
Synthesis of 8-aminomorphans with high KOR affinity
2021
2-Azabicyclo[3.3.1]nonanes (morphans) with a (3,4-dichlorophenyl)acetyl group at 2-position and a pyrrolidino moiety at 8-position were designed as conformationally restricted analogs of piperidine-based KOR agonists. The synthesis started with 4-oxopiperidine-2-carboxylic acid comprising 13 reaction steps. At first the ketone 10 was transformed into diester 7 bearing a propionate side chain. Dieckmann condensation of diester 7 to afford bicyclic enolester 14 and subsequent Krapcho deethoxycarbonylation represent the key steps of the synthesis. The enantiomeric pyrrolidines (1S,5R,8R)-5a and (1R,5S,8S)-5a were separated by chiral HPLC. The eutomer (1S,5R,8R)-5a showed high KOR affinity (K-i…
CREAPP K6-12: Tool to evaluate the creative potential of app oriented to the design of personal digital storytelling
2018
An instrument is presented that allows primary school teachers to evaluate the potentiality to develop creativity that have playful online app K6-12 focused on the development of digital storytelling (DST), so they can select those that can be used in the classroom for that purpose. The instrument validated consists of 48 indicators associated with the six dimensions of the creativity: flexibility, originality, fluency, problem solving, elaboration of products and co-edition and dissemination. It was designed based on the opinions of experts in creativity and Information and Communication Technologies of the didactic field, theory of education and methodology; also with the assessments and…
Preiļu novada Salas pamatskolas vēsture dokumentos un mutvārdu vēstures stāstos
2019
Bakalaura darba “Preiļu novada Salas pamatskolas vēsture dokumentos un mutvārdu vēstures stāstos” mērķis ir izpētīt vēl līdz šim neizpētītu vēsturi par Preiļu novada Salas pamatskolu, veikt vēstures dokumentu izpēti un ierakstīt mutvārdu vēstures liecības, rezultātā iegūt vērtīgus materiālus un saglabāt tos. Pētījuma teorētisko pamatu veido dokumentu analīzes, mutvārdu vēstures un interviju apskats, kā arī sociālā kapitāla teorijas apskats. Pētījumā izmantotas tādas pētniecības metodes kā dokumentu analīze un nestrukturētā intervija. Pētījuma rezultātā tika iegūta informācija par Preiļu novada Salas pamatskolas vēsturi – tās pirmsākumiem, attīstību, cilvēkiem, notikumiem līdz pat mūsdienām.…
Agro jauno laiku Rīgas kapsētu apbedījumu izpēte ar senās DNS analīzēm: nozīmīgākās pieejas un izpētes perspektīvas
2020
Bakalaura darba mērķis ir noskaidrot, kā ar senās DNS analīžu palīdzību ir iespējams papildināt jau esošās zināšanas, kas iegūtas ar tādām pētniecības metodēm kā literatūras un avotu analīze, kā arī arheoloģijas metodēm, kā piemēru izmantojot konkrētus agro jauno laiku Rīgas apbedījumus. Darba ietvaros tika veikta senās DNS izdalīšana un analīze, kuras rezultāti sasaistīti ar apbedījumu arheoloģisko un vēsturisko kontekstu, tādejādi izvirzot populāciju ģenētikas teorijā balstītas hipotēzes par konkrēto indivīdu izcelsmi. Darba rezultātā noteikta aptuvena izcelsme no mātes puses trijiem un dzimums visiem sešiem no pētāmajiem indivīdiem. Apbedītajiem konstatēti dažādi izcelsmes reģioni, kas a…
Preclinical evidence of new opioid modulators for the treatment of addiction.
2010
Addiction to opiates is one of the most severe forms of substance dependence, and despite a variety of pharmacological approaches to treat it, relapse is observed in a high percentage of subjects. New pharmacological compounds are necessary to improve the outcome of treatments and reduce adverse side effects. Moreover, drugs that act on the opioid system can also be of benefit in the treatment of alcohol or cocaine addiction. AREA COVERED BY THIS REVIEW: Recent preclinical studies of pharmacological agents for the treatment of opiate addiction (2008 to the present date).The reader will be informed of the latest drugs shown in animal models to modify dependence on opiates and the reinforcing…