Search results for " LAB"

José Vidal Beneyto, un sociólogo que interpreta y hace historia: "La conflictividad laboral no aumentará en 1983"

1983

Role of nitric oxide and nitric oxide synthases in experimental models of denervation and reinnervation.

2001

Nitric oxide (NO) is a short-living free molecule synthesized by three different isoforms of nitric oxide synthases (NOS)—neuronal NOS, endothelial NOS, and inducible NOS—associated with neuromuscular transmission, muscle contractility, mitochondrial respiration, and carbohydrate metabolism in skeletal muscle. Neuronal NOS is constitutively expressed at the muscle fiber sarcolemma linked to the dystrophin-glycoprotein complex and concentrated at the neuromuscular endplate. There is increasing evidence that altered expression of neuronal NOS plays a role in muscle fiber damage in neuromuscular diseases such as dystrophinopathies and denervating disorders. Although there have been some previo…

Globalización y Relaciones laborales : la individualización

2004

-Carlos.L.Alfonso@uv.es

Pulsed EPR determination of water accessibility to spin-labeled amino acid residues in LHCIIb.

2009

Membrane proteins reside in a structured environment in which some of their residues are accessible to water, some are in contact with alkyl chains of lipid molecules, and some are buried in the protein. Water accessibility of residues may change during folding or function-related structural dynamics. Several techniques based on the combination of pulsed electron paramagnetic resonance (EPR) with site-directed spin labeling can be used to quantify such water accessibility. Accessibility parameters for different residues in major plant light-harvesting complex IIb are determined by electron spin echo envelope modulation spectroscopy in the presence of deuterated water, deuterium contrast in …

Hybrid Chelator-Based PSMA Radiopharmaceuticals: Translational Approach

2021

(1) Background: Prostate-specific membrane antigen (PSMA) has been extensively studied in the last decade. It became a promising biological target in the diagnosis and therapy of PSMA-expressing cancer diseases. Although there are several radiolabeled PSMA inhibitors available, the search for new compounds with improved pharmacokinetic properties and simplified synthesis is still ongoing. In this study, we developed PSMA ligands with two different hybrid chelators and a modified linker. Both compounds have displayed a promising pharmacokinetic profile. (2) Methods: DATA5m.SA.KuE and AAZTA5.SA.KuE were synthesized. DATA5m.SA.KuE was labeled with gallium-68 and radiochemical yields of various…

In vivo comparison of DOTA based 68Ga-labelled bisphosphonates for bone imaging in non-tumour models.

2013

Bone metastases are a class of cancerous metastases that result from the invasion of a tumor into bone. The solid mass which forms inside the bone is often associated with a constant dull ache and severe spikes in pain, which greatly reduce the quality of life of the patient. Numerous (99m)Tc-labeled bisphosphonate functionalised complexes are well established tracers for bone metastases imaging. The objective of this research was to evaluate the pharmacokinetics and behaviour of three DOTA based bisphosphonate functionalised ligands (BPAMD, BPAPD and BPPED), using both (68)Ga μ-PET in vivo imaging and ex vivo biodistribution studies in healthy Wistar rats. The compounds were labelled with …

Taenia asiatica: the Most Neglected Human Taenia and the Possibility of Cysticercosis

2013

Not only Taenia solium and Taenia saginata, but also Taenia asiatica infects humans. The last species is not included in the evaluation of the specificity of the immunodiagnostic techniques for taeniasis/cysticercosis. There is currently no specific immunodiagnostic method for T. asiatica available. Therefore, due to the fact that molecular techniques (the only tool to distinguish the 3 Taenia species) are normally not employed in routine diagnostic methods, the 2 questions concerning T. asiatica (its definite geographic distribution and its ability to cause human cysticercosis), remain open, turning T. asiatica into the most neglected agent of human taeniasis-cysticercosis.

Laboratorio collegato al bando UMI Premio Archimede

2013

Viene descritta un'attività laboratoriale svolta nell'ambito del Progetto Lauree Scientifiche, collegata al Bando UMI sul Premio Archimede.

Tra teoria e pratica: la didattica del design nella Scuola di Cole, nel Bauhaus e nella HfG

2018

Il compito delle Università è la formazione dell’intellet- tuale per contribuire allo sviluppo culturale della società. Negli ultimi tempi, però, si assiste in Italia a uno scolla- mento tra quel che si studia nelle Università e quanto accade nel mondo del lavoro. Per dimostrare come la didattica (e la ricerca) debba essere legata al mondo pro- duttivo si esima l’attività di tre istituti che hanno segnato tappe fondamentali nella storia del design: la Government School di Londra, fondata da Henry Cole nell’Ottocento, il Bauhaus e la Hochschule für Gestaltung di Ulm. Il risul- tato è che il rapporto tra didattica, sperimentazione e mon- do produttivo, in questi luoghi di eccellenza, è sempre…

L’introduzione dei laboratori didattici nell’insegnamento universitario della Chimica in Europa e in Italia Il contributo di Stanislao Cannizzaro e d…

2014

Tra la fine del settecento e la prima metà si completò quel profondo processo che trasformò la Chimica da arte pratica al servizio di discipline più nobili, come la medicina, la farmacia, la metallurgia, in una scienza vera e propria, pienamente autonoma e saldamente fondata su basi numeriche. Questa trasformazione fu, in larga parte, il risultato dell’accurata e rigorosa attività sperimentale di molti scienziati di diversi paesi, che fornirono un fondamento teorico all’approccio fenomenologico che caratterizzava la disciplina. L’introduzione di corsi di laboratorio per studenti fu uno dei punti qualificanti della grande riforma della didattica e dell’organizzazione dei corsi che ebbe luogo…