Search results for " LAB"
showing 10 items of 2393 documents
A randomized, open-label, multicentre, phase IV study evaluating palbociclib plus endocrine treatment versus a chemotherapy based treatment strategy …
2017
TPS1115 Background: Although endocrine based therapy is recommended as first-line treatment in metastatic breast cancer (MBC) in patients with an HER2-/HR+ tumour up to 50% of the patients receive chemotherapy. Palbociclib (P) a CDK4/6 inhibitor improves PFS by 42% in endocrine sensitive and resistant HER2-/HR+ MBC when added to an endocrine therapy (ET). Patients included in clinical trials are often criticised not to be representative for real world breast cancer patients. Methods: Patients with first-line HER2-/HR+ MBC who are candidate for mono-chemotherapy will be eligible to be randomised 1:1 to receive either P plus ET per label or mono-chemotherapy per investigator´s choice with or…
La reforma de la negociación colectiva en la ley 3/2012
2012
En el presente estudio se analizan las reformas en el régimen jurídico de la negociación colectiva mediante la Ley 3/2012 (precedida por el RDL 3/2012) y el RDL 20/2012, que han perjudicado y dificultado algunas de las funciones esenciales de la negociación colectiva para la evitación de vacíos de regulación, progreso en las condiciones de trabajo y freno a la individualización, y que han hecho girar el eje de la negociación hacia la empresa, solución poco realista en un marco productivo dominado por la microempresa y que otorga más poder al empleador. Las reformas han afectado sobre todo a la situación del convenio una vez finalizada su vigencia pactada (régimen de prórroga), a la estructu…
Searches for transverse momentum dependent flow vector fluctuations in Pb-Pb and p-Pb collisions at the LHC
2017
The measurement of azimuthal correlations of charged particles is presented for Pb-Pb collisions at $\sqrt{s_{\rm NN}}=$ 2.76 TeV and p-Pb collisions at $\sqrt{s_{\rm NN}}=$ 5.02 TeV with the ALICE detector at the CERN Large Hadron Collider. These correlations are measured for the second, third and fourth order flow vector in the pseudorapidity region $|��|<0.8$ as a function of centrality and transverse momentum $p_{\rm T}$ using two observables, to search for evidence of $p_{\rm T}$-dependent flow vector fluctuations. For Pb-Pb collisions at 2.76 TeV, the measurements indicate that $p_{\rm T}$-dependent fluctuations are only present for the second order flow vector. Similar results hav…
Physics beyond colliders at CERN: beyond the Standard Model working group report
2019
The Physics Beyond Colliders initiative is an exploratory study aimed at exploiting the full scientific potential of the CERN's accelerator complex and scientific infrastructures through projects complementary to the LHC and other possible future colliders. These projects will target fundamental physics questions in modern particle physics. This document presents the status of the proposals presented in the framework of the Beyond Standard Model physics working group, and explore their physics reach and the impact that CERN could have in the next 10–20 years on the international landscape.
Searching for long-lived particles beyond the Standard Model at the Large Hadron Collider
2020
Particles beyond the Standard Model (SM) can generically have lifetimes that are long compared to SM particles at the weak scale. When produced at experiments such as the Large Hadron Collider (LHC) at CERN, these longlived particles (LLPs) can decay far from the interaction vertex of the primary proton–proton collision. Such LLP signatures are distinct from those of promptly decaying particles that are targeted by the majority of searches for new physics at the LHC, often requiring customized techniques to identify, for example, significantly displaced decay vertices, tracks with atypical properties, and short track segments. Given their non-standard nature, a comprehensive overview of LLP…
(Supplement Table S2) Results of 230Th/U-dating
2016
We compared the suitability of two skeletal materials of the Atlantic brain coral Diploria strigosa for 230Th/U-dating: the commonly used bulk material comprising all skeletal elements and the denser theca wall material. Eight fossil corals of presumably Last Interglacial age from Bonaire, southern Caribbean Sea, were investigated, and several sub-samples were dated from each coral. For four corals, both the ages and the activity ratios of the bulk material and theca wall agree within uncertainty. Three corals show significantly older ages for their bulk material than for their theca wall material as well as substantially elevated 232Th content and (230Th/238U) ratios. The bulk material sam…
Liderazgo femenino y felicidad en el trabajo: el papel mediador del intercambio líder-colaborador
2018
Objetivo: el objetivo de este artículo es examinar el papel del liderazgo femenino en la felicidad en el trabajo de sus colaboradores. Además, se analiza el papel mediador de la relación entre el líder y el colaborador, entendida como el intercambio líder-colaborador (LMX). Método: se ha utilizado la encuesta como método de investigación; se analizaron datos cuantitativos a nivel individual a través de modelos de ecuaciones estructurales. La muestra está compuesta por 292 empleados no directivos del sector hotelero español, para los que se analiza su percepción individual acerca de las variables objeto de estudio. Resultados: los resultados revelan que el liderazgo femenino ejerce un papel …
Hypervisor memory acquisition for ARM
2021
Abstract Cyber forensics use memory acquisition in advanced forensics and malware analysis. We propose a hypervisor based memory acquisition tool. Our implementation extends the volatility memory forensics framework by reducing the processor's consumption, solves the in-coherency problem in the memory snapshots and mitigates the pressure of the acquisition on the network and the disk. We provide benchmarks and evaluation.
Communities of Communication: Making Sense of the “Social” in Social Media
2012
As social media usage permeates people's lives, an increasing portion of their daily behavior leaves digital traces to be used by researchers. Social scientists can hope to gain new insight into the previously hidden but digitally recorded aspects of our digital social lives. Beyond aggregate and individual-level studies of user behavior, the digital traces also enable scientific examination of the structure of social interaction through networks. At the same time, the large scale and networked nature of social media data pose a new set of challenges to be overcome through the development of sound methodologies. We take stock of current methodological promises and challenges in social media…
20-Hydroxyecdysone-induced differentiation and apoptosis in the Drosophila cell line, l(2)mbn
2001
20-Hydroxyecdysone has an inhibitory effect on the proliferation of l(2)mbn cells, causes vacuolization and fragmentation of cells, and promotes a strong phagocytotic activity. From several lines of evidence, it can be concluded that 20-hydroxyecdysone induces apoptosis. Long-term video observations following the fate of individual cells, scanning and transmission electron microscopy reveal the typical characteristics of apoptosis: sequestration of small cellular protuberances or larger parts of the cell with nuclear fragments (apoptotic bodies), chromatin condensation, condensation and vesiculation of cytoplasm, whereas the mitochondria retain their normal appearance. The induction of apop…