Search results for " LAB"

ESBL-producing Klebsiella pneumoniae in a University hospital: Molecular features, diffusion of epidemic clones and evaluation of cross-transmission.

2021

The worldwide spread of Klebsiella pneumoniae producing extended-spectrum β-lactamase (ESBL-Kp) is a significant threat. Specifically, various pandemic clones of ESBL-Kp are involved in hospital outbreaks and caused serious infections. In that context, we assessed the phenotypic and molecular features of a collection of ESBL-Kp isolates in a French university hospital and evaluated the occurrence of potential cross-transmissions. Over a 2-year period (2017–2018), 204 non-duplicate isolates of ESBL-Kp were isolated from clinical (n = 118, 57.8%) or screening (n = 86, 42.2%) sample cultures. These isolates were predominantly resistant to cotrimoxazole (88.8%) and ofloxacin (82.8%) but remaine…

Correction: Recovery from Toxic-Induced Demyelination Does Not Require the NG2 Proteoglycan.

2018

[This corrects the article DOI: 10.1371/journal.pone.0163841.].

Vitamin D and immunomodulation: Is it time to change the reference values?

2017

The term "vitamin D" refers to two chemical compounds - ergosterol, or vitamin D2, and cholecalciferol, or vitamin D3. Active vitamin D3 is correctly regarded as a neurohormone due to its pleiotropic biological activities. Although the relation between vitamin D and calcium-phosphorus metabolism has never been discussed, the knowledge on many other roles vitamin D plays is growing fast. Briefly, vitamin D immunomodulation includes attenuation and stimulation of Th1 and Th2 cell proliferation, respectively. Similarly, vitamin D can induce or inhibit the synthesis, secretion, and release of anti- inflammatory (IL- 4 and IL-10) and pro-inflammatory (IL-1, TNF-α, IFN-γ) cytokines, respectivel…

Current trends in biocompatibility testing

1998

Biocompatibility remains the central theme for biomaterials applications in medicine. It is generally accepted that this term means not only absence of a cytotoxic effect but also positive effects in the sense of biofunctionality, i.e. promotion of biological processes which further the intended aim of the application of a biomaterial. The national and international standards for testing regimes represent a lowest common denominator for such applications and do not necessarily ensure that optimal function will be achieved. The authors' thesis is that biocompatibility testing has scope for extensive development with respect to biofunctionality. The present paper reviews current trends in the…

Oblate Collectivity in the Yrast Structure of 194Pt

2005

A deep inelastic reaction using a 460 MeV 82Se beam incident upon a thick 192Os target was performed at the Legnaro National Laboratory, Italy. The resulting γ-decays were measured using the GASP array. Results for 194Pt extend the known level scheme of the yrast structure from spin I = (12 ħ) to (20 ħ). The irregularities in the sequence of the new transition energies and total Routhian surface calculations show a breakdown in collectivity with an yrast oblate shape remaining to high spin. Rubio Barroso, Berta, Berta.Rubio@ific.uv.es

La necessità di Incipit Lab.

2018

Quale è la linea di confine fra un insegnamento ex cathedra e un laboratorio? In cosa la didattica della progettazione architettonica differisce da altri tipi di insegnamento? In che modo la teoria dell’architettura è presente in un laboratorio di progettazione architettonica? E quale interazione si stabilisce con le altre discipline? L’elenco delle domande potrebbe essere infinito e, soprattutto, a ciascuna di esse si dovrebbe aggiungere un quid specifico, relativo alle peculiarità dell’anno in cui la materia è offerta. Tali quesiti assumono un particolare rilievo se l’attenzione si ferma sull’avvio del percorso universitario, periodo in grado di indirizzare e influenzare le annualità succ…

A standard calculation methodology for human doubly labeled water studies.

2021

Summary The doubly labeled water (DLW) method measures total energy expenditure (TEE) in free-living subjects. Several equations are used to convert isotopic data into TEE. Using the International Atomic Energy Agency (IAEA) DLW database (5,756 measurements of adults and children), we show considerable variability is introduced by different equations. The estimated rCO2 is sensitive to the dilution space ratio (DSR) of the two isotopes. Based on performance in validation studies, we propose a new equation based on a new estimate of the mean DSR. The DSR is lower at low body masses (<10 kg). Using data for 1,021 babies and infants, we show that the DSR varies non-linearly with body mass betw…

Studies on the Biosynthesis of Paraherquamide: Synthesis and Incorporation of a Hexacyclic Indole Derivative as an Advanced Metabolite

2001

IL-4-mediated drug resistance in colon cancer stem cells

2008

Cancer stem cells are defined as cells able to both extensively self-renew and differentiate into progenitors. Cancer stem cells are thus likely to be responsible for maintaining or spreading a cancer, and may be the most relevant targets for cancer therapy. The CD133 glycoprotein was recently described as a reliable cancer stem-like cell marker in colon carcinoma. CD133+ cells are both necessary and sufficient to initiate tumour growth in animal models. The CD133+ cell population and spheroid cultures contain cells expressing the stem cell marker Musashi-1 which is involved in maintenance of stem cell fate in several tissues and importantly, this expression is maintained in stem-like cells…

Soluciones analíticas en la industria: calidad, seguridad y conciencia ambiental

2017

La industria es uno de los principales motores de la economía mundial. Una de las ocupaciones y preocupaciones principales del sector industrial, es la salvaguarda de la calidad de las materias primas utilizadas, el control de los procesos y de las infraestructuras involucradas en la manufactura, la seguridad de los trabajadores durante las etapas de producción y las emisiones de residuos al medio ambiente, tanto gaseosos, como líquidos o sólidos. Por último, y no menos importante, la calidad del producto manufacturado, que es la cabeza visible para el consumidor y repercute de forma directa en el prestigio y economía de la industria en cuestión. En la mayoría de los casos, las metodologías…