Search results for " Laboratory"

showing 10 items of 622 documents

Repeated Testing in SARS-CoV-2 Infection

2020

2019-20 coronavirus outbreakCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Pneumonia ViralTestingReal-Time Polymerase Chain ReactionSevere Acute Respiratory SyndromeArticleBetacoronavirusRepeated testingCOVID-19 TestingPandemicHumansMedicinePandemicsbiologyClinical Laboratory Techniquesbusiness.industrySARS-CoV-2COVID-19General Medicinebiology.organism_classificationTesting SARS-CoV-2 COVID-19VirologyCoronavirus InfectionsbusinessBetacoronavirusCoronavirus InfectionsMayo Clinic Proceedings
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The COVID-19 outbreak and rheumatologic skin diseases.

2020

2019-20 coronavirus outbreakLetterCoronavirus disease 2019 (COVID-19)business.industryClinical Laboratory TechniquesSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Pneumonia ViralMEDLINEOutbreakCOVID-19DermatologyGeneral MedicineVirologySkin DiseasesDisease OutbreaksArthritis RheumatoidCOVID-19 TestingRisk FactorsMedicineHumansLettersbusinessCoronavirus InfectionsPandemicsDermatologic therapy
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Comparison of Reported Deaths From COVID-19 and Increase in Total Mortality in Italy

2020

This analysis compares reported deaths from COVID-19, February 23 to April 4, 2020, and total mortality in Italy from January 12 through April 4 in the years 2015 through 2020.

2019-20 coronavirus outbreakmedicine.medical_specialtyCoronavirus disease 2019 (COVID-19)Pneumonia ViralMEDLINE01 natural sciences03 medical and health sciencesBetacoronavirus0302 clinical medicineCOVID-19 TestingPandemicInternal MedicineResearch LetterMedicineHumans030212 general & internal medicine0101 mathematicsMortalityMortality trendsDisease NotificationPandemicsbusiness.industryClinical Laboratory TechniquesSARS-CoV-2010102 general mathematicsCOVID-19covidPublic Reporting of Healthcare DataTotal mortalityItalyDisease NotificationEmergency medicinebusinessCoronavirus InfectionsCoronavirus Infections
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Safety and immunomodulatory effects of three probiotic strains isolated from the feces of breast-fed infants in healthy adults: SETOPROB study.

2013

We previously described the isolation and characterization of three probiotic strains from the feces of exclusively breast-fed newborn infants: Lactobacillus paracasei CNCM I-4034, Bifidobacterium breve CNCM I-4035 and Lactobacillus rhamnosus CNCM I-4036. These strains were shown to adhere to intestinal mucus in vitro, to be sensitive to antibiotics and to resist biliary salts and low pH. In the present study, a multicenter, randomized, double-blind, placebo-controlled trial with 100 healthy volunteers in three Spanish cities was carried out to evaluate the tolerance, safety, gut colonization and immunomodulatory effects of these three probiotics. Volunteers underwent a 15-day washout perio…

ARN Bacterianoved/biology.organism_classification_rank.speciesPhysiologylcsh:Medicine:Phenomena and Processes::Biological Phenomena::Ecological and Environmental Phenomena::Environment::Ecosystem::Biodiversity::Biota::Microbiota [Medical Subject Headings]law.inventionFecesProbioticAntibioticslawLactobacillus:Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Child Nutritional Physiological Phenomena::Infant Nutritional Physiological Phenomena::Breast Feeding [Medical Subject Headings]lcsh:Science:Chemicals and Drugs::Nucleic Acids Nucleotides and Nucleosides::Nucleic Acids::RNA::RNA Bacterial [Medical Subject Headings]BifidobacteriumMultidisciplinaryBifidobacterium brevebiologyLacticaseibacillus rhamnosusMicrobiotaHibridación in SituInterleukin-10:Organisms::Bacteria::Gram-Positive Bacteria::Lactobacillales::Lactobacillaceae::Lactobacillus [Medical Subject Headings]Breast FeedingBloodCytokinesFemaleResearch ArticleAdult:Anatomy::Fluids and Secretions::Feces [Medical Subject Headings]Lactobacillus paracasei:Organisms::Bacteria::Endospore-Forming Bacteria::Gram-Positive Endospore-Forming Bacteria::Gram-Positive Endospore-Forming Rods::Clostridium::Clostridium difficile [Medical Subject Headings]Microbiology:Chemicals and Drugs::Nucleic Acids Nucleotides and Nucleosides::Nucleic Acids::Nucleic Acid Probes::Oligonucleotide Probes [Medical Subject Headings]Double-Blind MethodLactobacillus rhamnosusHumansImmunologic Factors:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Histocytological Preparation Techniques::Staining and Labeling::In Situ Hybridization [Medical Subject Headings]FecesSafety studiesved/biologyProbioticslcsh:RClostridium difficile:Organisms::Bacteria::Gram-Positive Bacteria::Actinobacteria::Bifidobacterium [Medical Subject Headings]biology.organism_classificationImmunoglobulin ALactobacilluslcsh:QInterleukin-4BifidobacteriumBreast feedingSondas de OligonucleótidosPLoS ONE
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Viral exanthema as manifestation of SARS-CoV-2 infection

2020

Abstract Rationale: The clinical manifestations of the SARS-CoV-2 infection are mainly respiratory but the virus can cause a variety of symptoms. Dermatological findings are less well-characterized. Data is scarce on their timing, type and correlation with the immune response. Patient concerns: We present the case of SARS-CoV-2 infection in a previously healthy woman who presented with respiratory symptoms and developed anosmia, diarrhea, and an erythematous maculo-papular rash on day 15 from symptom onset. Diagnosis: The nasopharyngeal swab tested by real time PCR for COVID-19 was positive. We interpreted this as a viral exanthema likely caused by an immune response to SARS-CoV-2 nucleotid…

Administration TopicalvirusesAzithromycinAzithromycinLopinavirimmune responseCOVID-19 Testing0302 clinical medicine030212 general & internal medicineclinical manifestations4900virus diseasesLopinavirGeneral MedicineRashDrug CombinationsDiarrheaTreatment Outcome030220 oncology & carcinogenesisFemaleSymptom Assessmentmedicine.symptomCoronavirus InfectionsHydroxychloroquineResearch Articlemedicine.drugAdultmedicine.medical_specialtyPneumonia ViralAnosmiaAntiviral AgentsBetacoronavirus03 medical and health sciencesImmune systemImmunitymedicineHumansClinical Case ReportGlucocorticoidsPandemicsRitonavirClinical Laboratory TechniquesSARS-CoV-2business.industryfungiCOVID-19HydroxychloroquineExanthemabiochemical phenomena metabolism and nutritionDermatologybusinessanosmiaMedicine
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New insights into the cellular makeup and progenitor potential of palatal connective tissues

2017

The present study investigated the regenerative potential of connective tissues harvested from two palatal areas widely used as donor sites for muco-gingival surgical approaches. Connective tissue grafts (CTGs) were obtained by de-epithelialisation of a free gingival graft (deCTG) and by a split flap approach from a previous donor site (reCTG). Two types of mesenchymal stem cell (MSCs) were isolated and were named de-epithelialised MSCs (deMSCs) and re-entry MSCs (reMSCs). The cells were characterised and cellular functionality was investigated. CTGs were evaluated using immunohistochemical and ultrastructural approaches. No significant differences were observed regarding the frequency of c…

Adult0301 basic medicinePathologymedicine.medical_specialtyHistologyStromal cellCellular differentiationGingivaCD34Connective tissueAntigens CD34BiologyCell LineImmunophenotyping03 medical and health sciences0302 clinical medicineCell MovementOsteogenesismedicineHumansRegenerationProgenitor cellAutograftsInstrumentationConnective Tissue CellsLamina propriaAdipogenesisMucous MembranePalateStem CellsMesenchymal stem cellCell DifferentiationMesenchymal Stem Cells030206 dentistryPlatelet Endothelial Cell Adhesion Molecule-1Medical Laboratory TechnologyHyaluronan Receptors030104 developmental biologymedicine.anatomical_structureConnective TissueFemaleAnatomyStem cellChondrogenesisMicroscopy Research and Technique
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Carotid intima-media thickness measurement through semi-automated detection software and analysis of vascular walls

2013

AIM: The aim of the present study was to compare the semi-automatic measurement of carotid intima thickness (RFQIMT - Esaote, Italy), with the conventional method. METHODS: We enrolle 81 patients, mean age 46 years ±15, with no history of cardio-cerebrovascular events and we assessed the traditional cardiovascular risk factors. We examined the IMT of the common carotid artery with manual and RFQIMT method (based on the "Radio Frequency" signal), according to the ASE protocol. RESULTS: Semi-automatic measurement was on average lower than manual measurement (617 μm ±191 vs. 676 μm ± 222) with a statistically significant difference (P<0.01). In agreement with manual measurements, the values of…

AdultAutomation LaboratoryCarotid Artery DiseasesCarotid Artery CommonCarotid intima media thickness - Radio frequency identification device - Cardiovascular diseaseAge FactorsMiddle AgedCarotid Intima-Media ThicknessSettore MED/11 - Malattie Dell'Apparato CardiovascolarePredictive Value of TestsRisk FactorsImage Interpretation Computer-AssistedHumans
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Evaluation of CGMS® During Rapid Blood Glucose Changes in Patients with Type 1 Diabetes

2006

CGMS (Medtronic Minimed, Duesseldorf, Germany) allows continuous glucose monitoring. Recent studies with invasive monitoring techniques revealed discrepancies in blood glucose measurements obtained from different anatomical sites compared with those from the fingertip. The aim of this study was to investigate the CGMS and a device for alternative site testing (AST) during dynamic blood glucose changes and to compare these results with fingertip measurements.Twelve patients with type 1 diabetes (seven women, five men; age, 33.3 +/- 8.7 years) received a 75-g oral glucose load. Insulin was applied intravenously (rapid glucose decline) or subcutaneously (moderate glucose decline) in a dosage b…

AdultBlood GlucoseMalemedicine.medical_specialtyInjections SubcutaneousEndocrinology Diabetes and Metabolismmedicine.medical_treatmentEndocrinologyForearmDiabetes mellitusmedicineHumansHypoglycemic AgentsInsulinIn patientBlood Glucose MeasurementType 1 diabetesbusiness.industryBlood Glucose Self-MonitoringSite testingInsulinGlucose MeasurementMiddle Agedmedicine.diseaseSurgeryMedical Laboratory TechnologyDiabetes Mellitus Type 1medicine.anatomical_structureAnesthesiaInjections IntravenousFemalebusinessDiabetes Technology &amp; Therapeutics
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Influence of training and a maximal exercise test in analytical variability of muscular, hepatic, and cardiovascular biochemical variables.

2014

Short, middle, and long-term exercise, as well as the relative intensity of the physical effort, may influence a broad array of laboratory results, and it is thereby of pivotal importance to appropriately differentiate the 'physiologic' from the 'pathological' effects of exercise. Therefore, the values of some biomarkers in physically active subjects may be cautiously interpreted since the results may fall outside the conventional reference ranges. It has been demonstrated that middle and long-term endurance and/or strenuous exercise triggers transient elevations of muscular and cardiac biomarkers. However, no data have been published about the effect of short-term maximal exercise test on …

AdultCalcitoninMalemedicine.medical_specialtyCardiac biomarkersCardiovascular biomarkersCalcitonin Gene-Related PeptideClinical BiochemistryPhysical ExertionPhysical medicine and rehabilitationReference ValuesInternal medicineNatriuretic Peptide BrainmedicineCreatine Kinase MB FormHumansAspartate AminotransferasesProtein PrecursorsMuscle SkeletalPathologicalExerciseRelative intensitybiologyL-Lactate Dehydrogenasebusiness.industryC-reactive proteinSkeletal muscleHeartGeneral Medicinegamma-GlutamyltransferaseLaboratory resultsPeptide FragmentsTroponinmedicine.anatomical_structureexercise; laboratory; biomarkersC-Reactive ProteinLiverCardiologybiology.proteinExercise TestPhysical EnduranceMaximal exerciseSedentary BehaviorbusinesslaboratoryBiomarkersScandinavian journal of clinical and laboratory investigation
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United States and European Multicenter Prospective Study for the Analytical Performance and Clinical Validation of a Novel Sensitive Fully Automated …

2016

Abstract BACKGROUND The objective of this study is the validation and proof of clinical relevance of a novel electrochemiluminescence immunoassay (ECLIA) for the determination of serum calcitonin (CT) in patients with medullary thyroid carcinoma (MTC) and in different diseases of the thyroid and of calcium homeostasis. METHODS This was a multicenter prospective study on basal serum CT concentrations performed in 9 US and European referral institutions. In addition, stimulated CT concentrations were measured in 50 healthy volunteers after intravenous calcium administration (2.5 mg/kg bodyweight). RESULTS In total, 1929 patients and healthy controls were included. Limits of blank, detection, …

AdultCalcitoninMalemedicine.medical_specialtyPercentileClinical Biochemistry030209 endocrinology & metabolismGastroenterologySensitivity and SpecificityThyroid carcinoma03 medical and health sciences0302 clinical medicineInternal medicinemedicineHumansClinical significanceProspective StudiesProspective cohort studyCalcium metabolismAutomation LaboratoryImmunoassaymedicine.diagnostic_testbusiness.industryBiochemistry (medical)ThyroidReproducibility of ResultsReference StandardsUnited StatesEuropeEndocrinologymedicine.anatomical_structureCalcitonin030220 oncology & carcinogenesisImmunoassayCalciumFemalebusinessClinical chemistry
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