Search results for " Lamin"
showing 10 items of 148 documents
On the influence of gravitational and centrifugal buoyancy on laminar flow and heat transfer in curved pipes and coils
2015
Abstract The effects of gravitational and centrifugal buoyancy on laminar flow and heat transfer in curved and helical pipes were investigated by numerical simulation. Six dimensionless numbers characterizing the problem were identified, and an analysis was conducted on the possible combinations of signs of the gravitational and centrifugal buoyancy effects. Two distinct Richardson numbers were introduced in order to quantify the importance of the two types of buoyancy, and it was shown that, in the case of heating from the wall, a maximum realizable value of the centrifugal Richardson number exists which is a linear function of the curvature δ (ratio of pipe radius a to curvature radius c)…
A BMP7 Variant Inhibits Tumor Angiogenesis In Vitro and In Vivo through Direct Modulation of Endothelial Cell Biology
2015
Bone morphogenetic proteins (BMPs), members of the TGF-β superfamily, have numerous biological activities including control of growth, differentiation, and vascular development. Using an in vitro co-culture endothelial cord formation assay, we investigated the role of a BMP7 variant (BMP7v) in VEGF, bFGF, and tumor-driven angiogenesis. BMP7v treatment led to disruption of neo-endothelial cord formation and regression of existing VEGF and bFGF cords in vitro. Using a series of tumor cell models capable of driving angiogenesis in vitro, BMP7v treatment completely blocked cord formation. Pre-treatment of endothelial cells with BMP7v significantly reduced their cord forming ability, indicating …
Unusual basement layer in the midgut of gammaridean Niphargus virei Chevreux (Crustacea, Amphipoda).
1988
The basement membrane of the midgut and posterior caeca epithelium in the gammaridean amphipod Niphargus virei Chevreux, 1896 is made of an unusual structure. This basal lamina, properly called “basal layer”, shows a dense sheet formed by a system of dense hexagonal plates connected by thin filaments. Histochemical studies and enzymatic reactions lead to the conclusion that these structures are proteinaceous, without collagenous protein, and embedded in a neutral polysaccharide matrix. The possible mechanical significance of these mesenteric structures is discussed.
Flying laser spot thermography for the inspection of aerospace grade Fibre Metal Laminates
2017
This work analyses a Non Destructive Testing approach for the detection of interlayer disbonds in aerospace grade Fibre Metal Laminates (FMLs). The NDT setup consists of a continuous laser, focused and moved over the material surface, while an IR thermal camera acquires its thermal footprint. A numerical model of the NDT setup is presented, where the material thermal response is analysed to evaluate the features of the defects signatures. In particular, the response from various types of FMLs is evaluated.
A quantitative investigation on the thermoelastic effect of CFRP laminates
2009
The thermoelastic effect on CFRP laminates with various lay-ups is investigated. A thick low crimp unidirectional fabric reinforcement is adopted. The measured thermoelastic signal is compared with predictions from two analytical models based on the meso-mechanical bulk properties of the lamina and on assuming a strain witness behaviour of the surface resin rich layer.
Large deflection analysis of magneto-electro-elastic laminates
2013
Magneto-electro-elastic (MEE) composites containing piezoelectric and piezo-magnetic phases have recently emerged for many application smart structures technology. In this framework, the development of tools to analyze the MEE laminates is essential for their efficient design. In the present work, a model for the large deflection analysis of MEE laminated plates is proposed. The first order shear deformation theory and the von Karman stress function approach are employed to model the mechanical behavior whereas quasi-static behavior is assumed for the electro-magnetic quantities. First, the magneto-electric problem is solved in terms of the plate mechanical primary variables. In turn, this …
Distribution patterns in glycoconjugate expression during the development of the rat palate.
1994
The distribution of complex carbohydrate structures during the embryonic development of the rat palate was analysed by examining lectin-binding patterns in serial paraffin and cryostat sections. With few exceptions, the binding patterns showed a general increase in lectin receptors in the more developed stages of palatogenesis. High mannose oligosaccharides were especially amplified during development. Terminal fucose molecules were not expressed. In contrast, terminal sialic acid molecules were ubiquitously distributed in epithelial and mesenchymal tissues. Non-sialylated terminal N-acetylglucosamine was specifically restricted to evolving bone matrix. Before palatal fusion, quantitative b…
Immunocytochemistry of M-cadherin in mature and regenerating rat muscle
1994
Background: Cadherins are transmembrane proteins mediating calcium-dependent cell–cell adhesion in a cell type-specific manner by means of homophilic binding. M(muscle)-cadherin is a recently detected member of the cadherin family. Methods: We have investigated the localization of M-cadherin innormal and aneurally regenerating skeletal muscle of rat by means of pre-embedding immunocytochemistry. The antibody was directed against the extra-cellular domain of M-cadherin. Results: Myoblasts and myotubes in regenerating muscles tended to be arranged in clusters enclosed by a common basal lamina. Satellite cells of mature muscle fibers were attached to the underlying fiber without separating bas…
Modeling human osteosarcoma in mice through 3AB‐OS cancer stem cell xenografts
2012
Osteosarcoma is the second leading cause of cancer-related death for children and young adults. In this study, we have subcutaneously injected—with and without matrigel—athymic mice (Fox1nu/nu) with human osteosarcoma 3AB-OS pluripotent cancer stem cells (CSCs), which we previously isolated from human osteosarcoma MG63 cells. Engrafted 3AB-OS cells were highly tumorigenic and matrigel greatly accelerated both tumor engraftment and growth rate. 3AB-OS CSC xenografts lacked crucial regulators of beta-catenin levels (E-cadherin, APC, and GSK-3beta), and crucial factors to restrain proliferation, resulting therefore in a strong proliferation potential. During the first weeks of engraftment 3AB-…
Fine structural features of the cerebral microvasculature in hydrocephalic human infants: correlated clinical observations.
1989
Four of 30 human cerebral cortex biopsies from infants ranging from four days to about ten years treated for hydrocephalus by shunt operations are described paying special attention to the vascular structures. The biopsy specimens were studied in semi-thin and ultrathin sections. Attention is drawn to the role of pinocytotic vesicles found in capillaries and smaller vessels as a possible transcellular route for the hydrocephalic oedema resolution. No intercellular dehiscences or the so called blisters were observed. With the passage of time, the number of membrane bound vesicles increased and arrays of pinocytotic vesicles were discernible both on the abluminal as well as luminal aspect of …