Search results for " Left"

Late gadolinium enhancement-cardiovascular magnetic resonance identifies coronary artery disease as the aetiology of left ventricular dysfunction in …

2009

Aims We evaluated the ability of late gadolinium enhancement (LGE) using cardiovascular magnetic resonance (CMR) to identify acute new-onset heart failure (HF) with left ventricular systolic dysfunction (LVSD), whether or not in relation to underlying coronary artery disease (CAD), in patients with no clinical evidence of associated ischaemic cardiomyopathy. Methods and results Hundred consecutive patients admitted with acute new-onset decompensated HF and EF ,40%, with no clinical or electrocardiographic data suggestive of CAD. The patients were classified according to the presence or absence of significant CAD (stenosis � 70% in at least one major vessel). Twenty-one patients (21%) had si…

Heart-targeted overexpression of caspase3 in mice increases infarct size and depresses cardiac function

2001

Up-regulation of proapoptotic genes has been reported in heart failure and myocardial infarction. To determine whether caspase genes can affect cardiac function, a transgenic mouse was generated. Cardiac tissue-specific overexpression of the proapoptotic gene Caspase3 was induced by using the rat promoter of α-myosin heavy chain, a model that may represent a unique tool for investigating new molecules and antiapoptotic therapeutic strategies. Cardiac-specific Caspase3 expression induced transient depression of cardiac function and abnormal nuclear and myofibrillar ultrastructural damage. When subjected to myocardial ischemia–reperfusion injury, Caspase3 transgenic mice showed increased inf…

Estimation of Purkinje trees from electro-anatomical mapping of the left ventricle using minimal cost geodesics

2015

The electrical activation of the heart is a complex physiological process that is essential for the understanding of several cardiac dysfunctions, such as ventricular tachycardia (VT). Nowadays, patient-specific activation times on ventricular chambers can be estimated from electro-anatomical maps, providing crucial information to clinicians for guiding cardiac radio-frequency ablation treatment. However, some relevant electrical pathways such as those of the Purkinje system are very difficult to interpret from these maps due to sparsity of data and the limited spatial resolution of the system. We present here a novel method to estimate these fast electrical pathways from the local activati…

Chirurgische Behandlung des hypoplastischen Linksherzsyndroms

1999

Kinder mit dem angeborenen Herzfehler eines hypoplastischen Linksherzsyndroms haben ohne fruhzeitige chirurgische Behandlung eine extrem ungunstige Prognose. Anhand einer retrospektiven Funf-Jahres-Analyse werden die Moglichkeiten und Ergebnisse der herzerhaltenden palliativen Rekonstruktion dargestellt.

Motor development of infants with univentricular heart at the ages of 16 and 52 weeks

2013

Purpose To compare the motor development of patients with hypoplastic left heart syndrome (HLHS) and other types of univentricular heart (UVH) with peers who are healthy at the ages of 16 and 52 weeks. Methods Motor development was assessed with the Alberta Infant Motor Scale (AIMS). Results Both the 23 patients with HLHS and the 13 patients with UVH had lower total AIMS scores in both observations than the controls. At the age of 52 weeks, patients with HLHS had significantly lower scores in all 4 AIMS subscales, whereas patients with UVH had lower scores only in the prone and standing subscales. Conclusion Motor development of patients with HLHS or UVH is delayed during the first year of …

Adjustable tourniquet to manipulate pulmonary blood flow after Norwood operations

2000

Abstract Background . Survival after first-stage palliative Norwood operations for single ventricle with systemic outflow obstruction is mainly dependent on a balanced ratio of pulmonary blood flow to systemic blood flow. Here we report the clinical results using a modified technique that allows a controlled systemic-to-pulmonary shunt flow to prevent pulmonary overcirculation. Methods . From 1995 to 1998, of 26 infants undergoing first-stage palliative Norwood operations, 7 had placement of an adjustable tourniquet around a modified right Blalock-Taussig shunt. Results . Hospital survival was 20 of 26 patients (77%). All 7 patients in whom snaring of the shunt was indicated survived. Two p…

Beyond left ventricular ejection fraction there is a right heart that pumps.

2017

Role of functional mitral regurgitation in heart failure with preserved ejection fraction: an unrecognized protagonist?

2016

INCREASED MACROPHAGE COLONY STIMULATING FACTOR CONCENTRATIONS ARE ASSOCIATED WITH LEFT VENTRICLE SYSTOLIC DYSFUNCTION IN PATIENTS WITH ACUTE CORONARY…

2007

INCREASED MACROPHAGE COLONY STIMULATING FACTOR CONCENTRATIONS ARE ASSOCIATED WITH LEFT VENTRICLE SYSTOLIC DYSFUNCTION IN PATIENTS WITH ACUTE CORONARY SYNDROMES

Gli ebrei in Italia, il dibattito su Israele e la questione ebraica. Quattro riflessioni recenti

2022

La storia degli ebrei nell'Italia contemporanea è stata molto discussa dalla recente storiografia. In questa nota si prendono in esame quattro libri pubblicati tra il 2018 e il 2020 che affrontano il tema da prospettive differenti come il ruolo politico degli ebrei nell'Italia liberale e negli anni della grande guerra, la storia delle persecuzioni in età fascista, il problematico avvento della Repubblica, la raffigurazione degli ebrei e di Israele nelle sinistre italiane e la più generale percezione di Israele nel mondo politico e culturale italiano.