Search results for " Library"

Grāmata. Zīme. Krāsa

2020

Selective MicroRNA-Offset RNA Expression in Human Embryonic Stem Cells

2015

Small RNA molecules, including microRNAs (miRNAs), play critical roles in regulating pluri-potency, proliferation and differentiation of embryonic stem cells. miRNA-offset RNAs (moRNAs) are similar in length to miRNAs, align to miRNA precursor (pre-miRNA) loci and are therefore believed to derive from processing of the pre-miRNA hairpin sequence. Recent next generation sequencing (NGS) studies have reported the presence of moRNAs in human neurons and cancer cells and in several tissues in mouse, including pluripotent stem cells. In order to gain additional knowledge about human moRNAs and their putative development-related expression, we applied NGS of small RNAs in human embryonic stem cel…

Reference density trends in the major disciplines

2018

Abstract The aim of this study was to determine whether different areas of knowledge presented different behaviour with regard to the number of references cited per journal document or if, conversely, they shared the same reference density practices. Bibliometric and bibliographic data were collected from 27,141 journals (indexed between 2001 and 2015 in the SCImago Journal & Country Rank (SJR)) and the growth rates in reference density and number of documents and journals in each category were calculated at different levels of aggregation. Our analysis identified that (a) mean reference density values in some Social Sciences and Arts and Humanities categories were equal to or higher than t…

Finding Invariants of Group Actions on Function Spaces, a General Methodology from Non-Abelian Harmonic Analysis

2008

In this paper, we describe a general method using the abstract non-Abelian Fourier transform to construct “rich” invariants of group actions on functional spaces.

Overcoming barriers to evidence-based patient blood management: a restricted review

2020

Abstract Background Blood transfusions are associated with a range of adverse patient outcomes, including coagulopathy, immunomodulation and haemolysis, which increase the risk of morbidity and mortality. Consideration of these risks and potential benefits are necessary when deciding to transfuse. Patient blood management (PBM) guidelines exist to assist in clinical decision-making, but they are underutilised. Exploration of barriers to the implementation and utilisation of the PBM guidelines is required. This study aimed to identify common barriers and implementation strategies used to implement PBM guidelines, with a comparison against current expert opinion. Methods A restricted review a…

Comparison of healthy behavior in Ukrainian and Polish students of physical education

2021

Introduction: This study aimed to examine the healthy behaviors in undergraduate students of Physical Education (PE) from Ukraine and Poland in comparison to the control sample of students of other faculties. Material and methods: The group of 564 university students (67% of males), ranging in age from 18 to 41 years (M = 22.05, SD = 2.49), was surveyed using a written form of the Health Behavior Inventory (HBI). The HBI includes the following four subscales: healthy habits, nutrition (HHN), preventive behavior (PB), positive adjustments (PA), and healthy practices (HP). Undergraduates' sample consisted of 25% Ukrainian students of PE faculty, 30% Polish PE students, and 45% Polish sample o…

Análisis del proceso de internacionalización de la investigación española en ciencia y tecnología (1980-2007)

2012

The process of scientific internationalization in Spain is based on an analysis of the growth of scientific publications and the evolution of international collaboration in Spanish scientific papers indexed in the Science Citation Index-Expanded database between 1980 and 2007. The article examines science policies in Spain together with the investments in economic and human resources devoted to research, and their effects on the internationalization process. Scholarly research in Spain has become increasingly international over the last three decades. The main features of this process have been a linear growth of productivity in terms of the number of papers published per year; a progressiv…

Artificial Chromosomes to Explore and to Exploit Biosynthetic Capabilities of Actinomycetes

2012

Actinomycetes are an important source of biologically active compounds, like antibiotics, antitumor agents, and immunosuppressors. Genome sequencing is revealing that this class of microorganisms has larger genomes relative to other bacteria and uses a considerable fraction of its coding capacity (5–10%) for the production of mostly cryptic secondary metabolites. To access actinomycetes biosynthetic capabilities or to improve the pharmacokinetic properties and production yields of these chemically complex compounds, genetic manipulation of the producer strains can be performed. Heterologous expression in amenable hosts can be useful to exploit and to explore the genetic potential of actinom…

RCS1, a gene involved in controlling cell size inSaccharomyces cerevisiae

1991

Cloning and sequencing of RCS1, Saccharomyces cerevisiae gene whose product seems to be involved in timing the budding event of the cell cycle, is described. A haploid strain in which the 3'-terminal region of the chromosomal copy of the gene has been disrupted produces cells that are, on average, twice the size of cells of the parental strain. The critical size for budding in the mutant is similarly increased, and the disruption mutation is dominant in a diploid heterozygous for the RCS1 gene. Spores from this diploid have a reduced ability to germinate, the effect being more pronounced in the spores carrying the disrupted copy of RCS1. However, disrupted cells recover from alpha-factor tr…

Measuring dissatisfaction with coauthorship: An empirical approach based on the researchers’ perception

2019

Abstract Increasing levels of collaboration constitute one of the characteristics of science. However, the knowledge production system is based on a fundamental discordance: on the one hand, it is cooperative in nature, with links articulated through coauthorships, and on the other, the systems for assigning merit and distributing rewards function on an individual scale. This contradiction can give rise to dysfunction and inappropriate practices. This study analyses researchers’ perceptions about the problems associated with authorship in scientific publications. We make use of a coauthorship dissatisfaction index that measures the degree of dissatisfaction with the author order on the byli…