Search results for " Library"

showing 4 items of 734 documents

Baculovirus display strategies: Emerging tools for eukaryotic libraries and gene delivery

2004

Recombinant baculoviruses have been extensively used as vectors for abundant expression of a large variety of foreign proteins in insect cell cultures. The appeal of the system lies essentially in easy cloning techniques and virus propagation combined with the eukaryotic post-translational modification machinery of the insect cell. Recently, a novel molecular biology tool was established by the development of baculovirus surface display, using different strategies for presentation of foreign peptides and proteins on the surface of budded virions. This eukaryotic display system enables presentation of large complex proteins on the surface of baculovirus particles and has thereby become a ver…

virusesGenetic VectorsGreen Fluorescent ProteinsDNA RecombinantComputational biologyGene deliveryBiologyProteomicsBiochemistrychemistry.chemical_compoundPeptide LibraryGeneticsAnimalsHumansGenomic libraryTransgenesPeptide libraryMolecular BiologyGene LibraryCloningGene Transfer TechniquesGenetic TherapyVirologyLuminescent ProteinsCapsidchemistryDNA ViralBaculoviridaeFunctional genomicsDNABriefings in Functional Genomics and Proteomics
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The mitogen-activated protein kinase p38 pathway is conserved in metazoans: Cloning and activation of p38 of the SAPK2 subfamily from the sponge Sube…

2000

Our recent data suggest that during auto- and allograft recognition in sponges (Porifera), cytokines are differentially expressed. Since the mitogen-activated protein kinase (MAPK) signal transduction modulates the synthesis and release of cytokines, we intended to identify one key molecule of this pathway. Therefore, a cDNA from the marine sponge Suberites domuncula encoding the MAPK was isolated and analyzed. Its encoded protein is 366 amino acids long (calculated Mr 42 209), has a TGY dual phosphorylation motif in protein kinase subdomain VIII and displays highest overall similarity to the mammalian p38 stress activated protein kinase (SAPK2), one subfamily of MAPKs. The sponge protein w…

xHot TemperatureUltraviolet RaysMolecular Sequence DataMarine BiologyBiologyMitogen-activated protein kinase kinasep38 Mitogen-Activated Protein KinasesMAP2K7Osmotic PressureAnimalsASK1Amino Acid Sequencec-RafGenes Immediate-EarlyConserved SequencePhylogenyGene LibraryModels GeneticSequence Homology Amino AcidMAP kinase kinase kinaseCyclin-dependent kinase 2Hydrogen PeroxideCell BiologyGeneral Medicinebiology.organism_classificationPoriferaEnzyme ActivationSuberites domunculaBiochemistrybiology.proteinCyclin-dependent kinase 9Mitogen-Activated Protein KinasesSequence AnalysisSignal TransductionBiology of the Cell
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Exploration des enjeux de la demande sociale pour les SIC

2016

Les Sciences de l’Information et de la Communication constituent un terrain d’observation privilégié du débat épistémologique opposant la recherche dite fondamentale à la recherche dite appliquée. Cette opposition produit systématiquement un déclassement qualitatif de la seconde au profit de la première. Nous souhaitons ici discuter de la pertinence même du débat ainsi que de ce déclassement qui en est la conséquence. La question est alors double : nos travaux s’inscrivent-il dans la recherche dite « appliquée » ? Sont-ils en cela moins valables scientifiquement que des recherches pouvant apparaître plus nobles car déconnectées d’une valorisation socio-économique ? En complément des élément…

épistémologie[SHS.INFO]Humanities and Social Sciences/Library and information sciencesGeography Planning and Developmentresearch transfer050801 communication & media studiesDevelopment[SHS.INFO] Humanities and Social Sciences/Library and information sciences[SHS]Humanities and Social Scienceslcsh:Communication. Mass media0508 media and communicationssciences de l’information et de la Communication050602 political science & public administrationfundamental researchdemande socialeComputingMilieux_MISCELLANEOUSPhilosophy05 social sciencesepistemologylcsh:P87-96lcsh:Z0506 political sciencelcsh:Bibliography. Library science. Information resourcesapplied researchexpertisesocial demand[SHS] Humanities and Social SciencesHumanities
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Ética, alfabetización económica e información como fundamentos de las 'sociedades resilientes' del siglo XXI

2016

Las bibliotecas han afrontado en los ultimos anos el envite de la crisis y los recortes presupuestarios. Las competencias economicas e informacionales son elementos fundamentales para la superacion de estas situaciones de crisis y tragedias potenciales. Aquella competencia o capacidad de hacer frente a una crisis y ser capaz de superarla es lo que se denomina resiliencia. La etica en el uso y tratamiento de la informacion, complementado por una adecuada alfabetizacion economica, es la propuesta aqui defendida para la conformacion de las “sociedades resilientes” del siglo XXI. Tras una introduccion multidisciplinar, abogando por la necesidad de la recuperacion de la etica en el conjunto de t…

éticaÈticaResilienciatransparenciainformación relevantealfabetización económicasociedades resilienteslcsh:Zlcsh:Bibliography. Library science. Information resources
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