Search results for " Library"
showing 10 items of 734 documents
Subcytocidal attack by staphylococcal alpha-toxin activates NF-kappaB and induces interleukin-8 production.
2001
ABSTRACTFormation of transmembrane pores by staphylococcal alpha-toxin can provoke a spectrum of events depending on target cell species and toxin dose, and in certain cases, repair of the lesions has been observed. Here, we report that transcriptional processes are activated as a response of cells to low toxin doses. Exposure of monocytic (THP-1) or epithelial (ECV304) cells to 40 to 160 ng/ml alpha-toxin provoked a drop in cellular ATP level that was followed by secretion of substantial amounts of interleukin-8 (IL-8). Cells transfected with constructs comprising the proximal IL-8 promoter fused to luciferase or to green fluorescent protein cDNA exhibited enhanced reporter gene expression…
Expert-based versus citation-based ranking of scholarly and scientific publication channels
2016
Abstract The Finnish publication channel quality ranking system was established in 2010. The system is expert-based, where separate panels decide and update the rankings of a set of publications channels allocated to them. The aggregated rankings have a notable role in the allocation of public resources into universities. The purpose of this article is to analyze this national ranking system. The analysis is mainly based on two publicly available databases containing the publication source information and the actual national publication activity information. Using citation-based indicators and other available information with association rule mining, decision trees, and confusion matrices, …
Vector coherent states and intertwining operators
2009
In this paper we discuss a general strategy to construct vector coherent states of the Gazeau-Klauder type and we use them to built up examples of isospectral hamiltonians. For that we use a general strategy recently proposed by the author and which extends well known facts on intertwining operators. We also discuss the possibility of constructing non-isospectral hamiltonians with related eigenstates.
Weak pseudo-bosons
2020
We show how the notion of {\em pseudo-bosons}, originally introduced as operators acting on some Hilbert space, can be extended to a distributional settings. In doing so, we are able to construct a rather general framework to deal with generalized eigenvectors of the multiplication and of the derivation operators. Connections with the quantum damped harmonic oscillator are also briefly considered.
Flexible latent trait aggregation to analyze employability after the Ph.D. in Italy
2015
The analysis of satisfaction, employability and economic perspectives after the Ph.D. in Italy has not received adequate attention in the past, especially in terms of comparison among universities. To analyze these aspects, in this paper we consider data from the survey ‘Statistica in TEma di Laureati e LAvoro’ on doctors who achieved the title on 2007, 2008 and 2009 [CILEA, Laureati STELLA, indagine occupazionale post-dottorato, dottori di ricerca 2007–2008, Tech. Rep., CILEA, Segrate, 2010; CILEA,Laureati STELLA, indagine occupazionale post-dottorato, dottori di ricerca 2008–2009, Tech. Rep., CILEA, Segrate, 2011]. To deal with the complex, multidimensional nature of the concept, we propo…
Understanding University Library Users' Mistreatment of Books
2009
This paper analyses university library users' attitudes towards book vandalism in order to develop a basis for intervention. Using a customer oriented approach data was collected from users who attended an academic library exhibition on vandalized books at a University campus. Respondants were asked both for their reactions to the vandalism as well as to suggest measures to solve this problem. Punishment and surveillance were most frequently mentioned as preventative measures although users also recognized the utility of the exhibition in increasing awareness of book mutilation. Further implications of social marketing for libraries are also discussed.
TB-Structure: Collective Intelligence for Exploratory Keyword Search
2017
In this paper we address an exploratory search challenge by presenting a new (structure-driven) collaborative filtering technique. The aim is to increase search effectiveness by predicting implicit seeker’s intents at an early stage of the search process. This is achieved by uncovering behavioral patterns within large datasets of preserved collective search experience. We apply a specific tree-based data structure called a TB (There-and-Back) structure for compact storage of search history in the form of merged query trails – sequences of queries approaching iteratively a seeker’s goal. The organization of TB-structures allows inferring new implicit trails for the prediction of a seeker’s i…
Employing artificial neural networks to find reaction coordinates and pathways for self-assembly
2021
Capturing the autonomous self-assembly of molecular building blocks in computer simulations is a persistent challenge, requiring to model complex interactions and to access long time scales. Advanced sampling methods allow to bridge these time scales but typically require to construct accurate low-dimensional representations of the transition pathways. In this work, we demonstrate for the self-assembly of two single-stranded DNA fragments into a ring-like structure how autoencoder architectures based on unsupervised neural networks can be employed to reliably expose transition pathways and to provide a suitable low-dimensional representation. The assembly occurs as a two-step process throug…
Sympathetic neurons can produce and respond to interleukin 6
1998
Neuronal expression of cytokines is an area of active investigation in the contexts of development, disease, and normal neural function. Although cultured rat sympathetic neurons respond very weakly to exogenous interleukin 6 (IL-6), we find that addition of soluble IL-6 receptor (sIL-6R) and IL-6 enhances neuronal survival in the absence of nerve growth factor. Neutralizing monoclonal antibodies against IL-6 block these effects. Addition of IL-6 and sIL-6R also induces a subset of neuropeptide and transmitter synthetic enzyme mRNAs identical to that demonstrated for leukemia inhibitory factor, ciliary neurotrophic factor, and oncostatin M. Both of these effects are duplicated by addition o…
Un sistema de indicadores para el seguimiento y evaluación de la gestión sostenible del patrimonio cultural
2013
This paper describes the general procedure followed to build a system of indicators for monitoring and evaluating the Strategy for Culture and Development of Spanish Cooperation. Taking the Sustainable Management of Cultural Heritage as a reference, in this study an approach is made to questions relative to: 1) the process of evaluating a list of indicators by a panel of experts using the Delphi technique, 2) the definition and calculation of a relative operational index, 3) the process of indicator selection, and lastly, 4) how the selected indicators were assigned to form part of the basic or strategic dimension on which the system is structured. En este trabajo se describe el procedimie…