Search results for " Local"

showing 10 items of 2101 documents

Pianificare l'innovazione locale. Strategie e progetti per lo sviluppo locale creativo: l'esperienza del SicaniLab

2017

La Sicilia è isola liquida per eccellenza, poiché non è solo circondata dall'acqua, ma racchiude al suo interno un mare fatto di arcipelaghi di comunità, punteggiati di centri storici collinari e montani, testimoni di una terra che era pascolo e nutrice di comunità. E i borghi della riforma agraria affiorano come scogli da un fertile passato produttivo, interrotto, e dialogano ancora silenti con i reticoli degli straordinari mosaici colturali dell’entroterra, connotati dai paesaggi produttivi e dalle nuove manifatture delle eccellenze agroalimentari. Questo ricco palinsesto di territori e paesaggi, culture e comunità, non va guardato con nostalgia, né governato come se fosse una marginalità…

SVILUPPO LOCALE URBANISTICA INNOVAZIONE SOCIALESettore ICAR/21 - Urbanistica
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EUROPA 2020 IN SICILIA E NEL MEZZOGIORNO: SPIN-OFF DI RICERCA, DISTRETTI HIGH-TECH E STRATEGIE DI INNOVAZIONE ISTITUZIONALE

2014

SVILUPPO LOCALEEUROPA 2O20INNOVAZIONE ISTITUZIONALESPIN-OFFEUROPA 2O20 SPIN-OFF DISTRETTI TECNOLOGICI INNOVAZIONE ISTITUZIONALE SVILUPPO LOCALESettore SECS-P/06 - Economia ApplicataDISTRETTI TECNOLOGICI
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Le politiche di riqualificazione urbana: esperienze europee a confronto

2017

In questo capitolo sono illustrati dei casi studio che possono essere considerati delle best practices per le iniziative di riquali cazione urbana attuate in Italia. Come vedremo, all’interno di alcuni di questi casi studio, la demolizione e la ricostruzione sono strumenti che hanno potuto manifestarsi a pieno. Mediante la presentazione di questi esempi sarà condotta una ricognizione dei principali modelli di rigenerazione urbana e delle matrici teoriche e politiche sottostanti che assolvono un ruolo fondamentale per agevolare la traduzione in pratica delle iniziative di intervento urbano e garantirne un ef cace impatto sul rafforzamento della competitività delle città. L’ef cacia di que…

SVILUPPO LOCALERIQUALIFICAZIONE URBANA SVILUPPO LOCALE EFFICACIARIQUALIFICAZIONE URBANAEFFICACIA
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Le politiche di riqualificazione urbana: il dibattito scientifico e i risultati della programmazione europea

2017

capitolo fornisce un inquadramento delle politiche di rigenerazione urbana che hanno visto come protagoniste le città europee negli ultimi due cicli di programmazione (1999-2006 e 2007-2013). chapter provides an overview of urban regeneration policies that have seen European cities as protagonists in the last two programming cycles (1999-2006 and 2007-2013).

SVILUPPO LOCALERIQUALIFICAZIONE URBANA SVILUPPO LOCALERIQUALIFICAZIONE URBANA
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The budding yeast Start repressor Whi7 differs in regulation from Whi5, emerging as a major cell cycle brake in response to stress

2020

ABSTRACT Start is the main decision point in the eukaryotic cell cycle at which cells commit to a new round of cell division. It involves the irreversible activation of a transcriptional programme through the inactivation of Start transcriptional repressors: the retinoblastoma family in mammals, or Whi5 and its recently identified paralogue Whi7 (also known as Srl3) in budding yeast. Here, we provide a comprehensive comparison of Whi5 and Whi7 that reveals significant qualitative differences. Indeed, the expression, subcellular localization and functionality of Whi7 and Whi5 are differentially regulated. Importantly, Whi7 shows specific properties in its association with promoters not share…

Saccharomyces cerevisiae ProteinsCell division[SDV]Life Sciences [q-bio]RepressorSaccharomyces cerevisiaeBiologyCell cycleCicle cel·lularStress13503 medical and health sciences0302 clinical medicineWhi7Gene Expression Regulation FungalmedicineWhi5030304 developmental biology0303 health sciencesRetinoblastomaCèl·lules eucariotesPromoterCell BiologyCell cycleSubcellular localizationmedicine.diseaseStartBudding yeastCell biologyRepressor ProteinsDecision points[SDV] Life Sciences [q-bio]SaccharomycetalesCell Division030217 neurology & neurosurgeryResearch Article
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Convergence of the target of rapamycin and the Snf1 protein kinase pathways in the regulation of the subcellular localization of Msn2, a transcriptio…

2002

The subcellular localization of Msn2, a transcriptional activator of STRE (stress response element)-regulated genes, is modulated by carbon source availability. In cells growing in glucose, Msn2 is located mainly in the cytosol, whereas in carbon source-starved cells, Msn2 is located largely inside the nucleus. However, in cells lacking Reg1 (the regulatory subunit of the Reg1/Glc7 protein phosphatase complex), the regulation of subcellular distribution is absent, Msn2 being constitutively present in the cytosol. The localization defect in these mutants is specific for carbon starvation stress, and it is because of the presence of an abnormally active Snf1 protein kinase that inhibits the n…

Saccharomyces cerevisiae ProteinsRecombinant Fusion ProteinsSaccharomyces cerevisiaeMitogen-activated protein kinase kinaseBiologyProtein Serine-Threonine KinasesBiochemistryASK1Molecular BiologyDNA PrimersSirolimusMAP kinase kinase kinaseBase SequenceKinaseCell BiologySubcellular localizationCarbonCell biologyCulture MediaDNA-Binding ProteinsCytosolBiochemistryTrans-ActivatorsCyclin-dependent kinase 9Nuclear localization sequenceSubcellular FractionsTranscription FactorsThe Journal of biological chemistry
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Oncological Outcomes of Primary vs. Salvage OPHL Type II: A Systematic Review

2022

Background: Open partial horizontal laryngectomy type II (OPHL type II) has two main aims: oncological radicality and laryngeal preservation. The aim of this review is to define and emphasize the oncological efficacy of OPHL type II, both as primary and salvage surgery, by analyzing the latest literature. Methods: The research was carried out on Pubmed, Scopus and Web of Science databases, by using strict keywords. Oncological outcomes were evaluated by the following parameters: overall survival, disease-specific survival, disease-free survival, local control, laryngeal preservation, local recurrence. Results: The review included 19 articles divided into three groups: (1) primary OPHL type …

Salvage TherapyHealth Toxicology and MutagenesisRPublic Health Environmental and Occupational HealthLaryngectomyHead and neck; Laryngectomy; Otolaryngology; Salvage therapy; Surgical oncology; Disease-Free Survival; Humans; Laryngectomy; Neoplasm Recurrence Local; Retrospective Studies; Salvage Therapy; Treatment Outcome; Laryngeal NeoplasmsDisease-Free Survivalhead and necksurgical oncologyNeoplasm RecurrenceTreatment OutcomeSettore MED/31 - OtorinolaringoiatriaLocalotolaryngologyMedicineHumansNeoplasm Recurrence LocalLaryngeal NeoplasmsRetrospective Studies
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Social capital, public expenditure and the quality of provision. The Sicilian experience

2013

L'articolo si inserisce all’interno del dibattito sul divario nella qualità dei servizi fra Nord e Sud d’Italia che recentemente è tornato a concentrarsi sul tema del capitale sociale, con lo scopo di ricostruire i processi attraverso i quali il capitale sociale influenza i rendimenti istituzionali, di qualificare la natura del nesso esistente, la sua variabilità nel tempo e fra diversi settori di intervento. A questo scopo l'articolo sviluppa una analisi fra i settori della sanità e della formazione professionale negli ultimi dieci anni in Sicilia. Questo articolo si inserisce all'interno del dibattito sul divario nella qualità dei servizi fra Nord e Sud d'Italia che recentemente è tornato…

Sanità Formazione professionale Capitale sociale divari territorialiH11 Structure Scope and Performance of GovernmentI18 - Government PolicySettore SPS/09 - Sociologia Dei Processi Economici E Del LavoroWelfareH75 - State and Local Government: HealthPublic HealthPublic PensionHealth; Education; Welfare; Public Pensions; I18 - Government Policy; Regulation; Public Health. [H11 - Structure Scope and Performance of Government; H75 - State and Local Government]EducationRegulation
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Quantifying Irrigated Winter Wheat LAI in Argentina Using Multiple Sentinel-1 Incidence Angles

2022

Synthetic aperture radar (SAR) data provides an appealing opportunity for all-weather day or night Earth surface monitoring. The European constellation Sentinel-1 (S1) consisting of S1-A and S1-B satellites offers a suitable revisit time and spatial resolution for the observation of croplands from space. The C-band radar backscatter is sensitive to vegetation structure changes and phenology as well as soil moisture and roughness. It also varies depending on the local incidence angle (LIA) of the SAR acquisition’s geometry. The LIA backscatter dependency could therefore be exploited to improve the retrieval of the crop biophysical variables. The availability of S1 radar time-series data at d…

Satellite ImageryLeaf Area Indexleaf area index; Sentinel-1; time-series; local incidence angle; Whittaker smoother; Gaussian processes regressionWheatWinterGeneral Earth and Planetary SciencesInviernoSentinel-1TrigoImágenes por SatélitesÍndice de Superficie FoliarIrrigationRiegoRemote Sensing; Volume 14; Issue 22; Pages: 5867
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Proprotein convertase 5/6 is critical for embryo implantation in women: regulating receptivity by cleaving ebp50, modulating ezrin binding, and membr…

2011

Establishment of endometrial receptivity is vital for successful embryo implantation; its failure causes infertility. Epithelial receptivity acquisition involves dramatic structural changes in the plasma membrane and cytoskeleton. Proprotein convertase 5/6 (PC6), a serine protease of the proprotein convertase (PC) family, is up-regulated in the human endometrium specifically at the time of epithelial receptivity and stromal cell decidualization. PC6 is the only PC member tightly regulated in this manner. The current study addressed the importance and mechanisms of PC6 action in regulating receptivity in women. PC6 was dysregulated in the endometrial epithelium during the window of implantat…

Scaffold proteinmedicine.medical_specialtySodium-Hydrogen ExchangersPlasma protein bindingBiologyEndometriumMiceEndocrinologyEzrinInternal medicinemedicineAnimalsHumansEmbryo ImplantationCytoskeletonCytoskeletonCellular localizationBinding proteinDecidualizationEpithelial CellsPhosphoproteinsProprotein convertaseCytoskeletal ProteinsEndocrinologyProprotein Convertase 5FemaleProtein Binding
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