Search results for " Localization"
showing 10 items of 319 documents
New insights in chemical reactivity from quantum chemical topology.
2021
International audience; Based on the quantum chemical topology of the modified electron localization function ELFx, an efficient and robust mechanistic methodology designed to identify the favorable reaction pathway between two reactants is proposed. We first recall and reshape how the supermolecular interaction energy can be evaluated from only three distinct terms, namely the intermolecular coulomb energy, the intermolecular exchange‐correlation energy and the intramolecular energies of reactants. Thereafter, we show that the reactivity between the reactants is driven by the first‐order variation in the coulomb intermolecular energy defined in terms of the response to changes in the numbe…
A high-temperature x-ray absorption spectroscopy study of
1996
We present for the first time a high-temperature x-ray absorption spectroscopy study of at the edge. The analysis both of the XANES and of the EXAFS regions shows that, in , a progressive localization of the 5d states following the temperature rise is accompanied at T > 350 K by a distortion of the octahedra, which increases up to the decomposition temperature . The distortion leads to the lowering of the rhenium site symmetry from and is due to the electron - phonon coupling of the 5d electrons with the and phonons and to the Jahn - Teller effect caused by the rhenium electron which becomes localized at high temperature.
Prédire le passé et le futur : rôle des représentations motrices dans l'inférence du mouvement
2012
The effectiveness of the visual system is permitted by a complex processing network, which relies on cortical, sub-cortical and peripheral structures. The purpose of this research is to improve the knowledge of the process sustaining the visual perception of motion, and to produce a computational model able to reproduce the features of human visual tracking of a moving object.This work includes an extensive bibliographic research, and a series of experiments. The thesis consists of two parts:The first part pertains to the determination of performance in the "backward" inference of a partially visible movement. It consist of defining the involvement of exogenous information (retinal signals)…
Filmu nosaukumu pragmatiskā adaptācija Latvijas auditorijai tulkojumos no angļu valodas latviešu un krievu valodā
2018
Maģistra darba tēma ir „Filmu nosaukumu pragmatiskā adaptācija Latvijas auditorijai tulkojumos no angļu valodas latviešu un krievu valodā”. Maģistra darba ietvaros veiktā pētījuma periods ir 25 gadi: no 1993. g. līdz 2018. g. Darba mērķis ir izpētīt, kā tiek tulkoti filmu nosaukumi no angļu valodas latviešu un krievu valodā, cik bieži tiek pielietota pragmatiskā adaptācija un lokalizācija, kā arī izpētīt filmas nosaukuma un vokatīvā teksta saikni. Būtiska maģistra darba pētījuma vadlīnija ir Andreja Veisberga un Ievas Zaubergas teorētiskais pamatojums. Rezultāti: Pēc daļēji strukturētās intervijas metodes tika aptaujāti eksperti, veikta kvalitatīvā un kvantitatīvā kontentanalīze, kurā izpēt…
CRITICAL ANALYSIS OF SHORELINE LOCALIZATION METHODS BY MEANS OF AERIAL OR SATELLITE IMAGERY ON MEDITERRANEAN SANDY BEACHES
2013
Shoreline localization is fundamental for designing and planning shore protection works as well as for managing and monitoring various anthropic activities along the coast. The sea-land boundary, however, changes continually with time because of waves and tides, which makes the shoreline detection complex and dubious and the boundary line finally assumed can only be conventional. In the last few decades the use of several geomorphologic indicators has been proposed, such as the berm above sea level, the groundwater exit point, historic high tide levels, etc., but the aim has not been achieved yet. Among the methods used, analysis of aerial and satellite imagery is common, in particular when…
A Deletion of the Nuclear Localization Signal Domain in the Fus Protein Induces Stable Post-stress Cytoplasmic Inclusions in SH-SY5Y Cells
2021
Mutations in Fused-in-Sarcoma (FUS) gene involving the nuclear localization signal (NLS) domain lead to juvenile-onset Amyotrophic Lateral Sclerosis (ALS). The mutant protein mislocalizes to the cytoplasm, incorporating it into Stress Granules (SG). Whether SGs are the first step to the formation of stable FUS-containing aggregates is still unclear. In this work, we used acute and chronic stress paradigms to study the SG dynamics in a human SH-SY5Y neuroblastoma cell line carrying a deletion of the NLS domain of the FUS protein (homozygous: ΔNLS–/–; heterozygous: ΔNLS+/–). Wild-type (WT) cells served as controls. We evaluated the subcellular localization of the mutant protein through immuno…
Unveiling the Unexpected Reactivity of Electrophilic Diazoalkanes in [3+2] Cycloaddition Reactions within Molecular Electron Density Theory
2021
The [3+2] cycloaddition (32CA) reactions of strongly nucleophilic norbornadiene (NBD), with simplest diazoalkane (DAA) and three DAAs of increased electrophilicity, have been studied within the Molecular Electron Density Theory (MEDT) at the MPWB1K/6-311G (d,p) computational level. These pmr-type 32CA reactions follow an asynchronous one-step mechanism with activation enthalpies ranging from 17.7 to 27.9 kcal·
Novel Insights into the Cellular Localization and Regulation of the Autophagosomal Proteins LC3A, LC3B and LC3C
2020
Macroautophagy is a conserved degradative process for maintaining cellular homeostasis and plays a key role in aging and various human disorders. The microtubule-associated protein 1A/1B light chain 3B (MAP1LC3B or LC3B) is commonly analyzed as a key marker for autophagosomes and as a proxy for autophagic flux. Three paralogues of the LC3 gene exist in humans: LC3A, LC3B and LC3C. The molecular function, regulation and cellular localization of LC3A and LC3C have not been investigated frequently, even if a similar function to that described for LC3B appears likely. Here, we have selectively decapacitated LC3B by three separate strategies in primary human fibroblasts and analyzed the evoked e…
Cellular and Subcellular Localization of Peroxidase Isoenzymes in Plants and Cell Suspension Cultures from Lupinus polyphyllus
1989
Abstract , leaf protoplasts and cell suspension cultures of Lupinus polyphyllus and isolated vacuoles were studied for cellular and subcellular localization of peroxidase isoenzymes. Isoelectric focusing revealed 16 peroxidase isoenzymes. The basic peroxidase isoenzymes are predominantly localized in the vacuole and, to a minor degree, unbound in the intercellular space. The acidic isoenzymes are cell wall-bound in plants and not detectable in suspension-cultured cells. Large amounts (up to 11.0 U/ml) of a single basic isoenzyme are detectable in the spent medium of cell suspension cultures.
Subcellular distribution of calpain-1 and calpain-2 as a key event for calpain-mediated functions in physiological and neoplastic mammary models
2019
Calpains are a family of calcium-dependent proteases, which modulate their substrates rather than degrade them in such a way that modifies them. Calpains deregulations have been determined as an aggravating factor of different diseases, including cancer. Nevertheless, there are no clear records about the particular contribution of each calpain isoform in physiological processes and how these isoforms are deregulated in pathological conditions. In vivo, each calpain isoform recognizes specific proteins as substrates, and it has been suggested that calpains subcellular localization might determine their substrate recognition, and consequently their functions. In the present study we have expl…