Search results for " MIC"

Activation of NF-kappaB and IL-8 by yersinia enterocolitica invasin protein is conferred by engagement of rac1 and MAP kinase cascades.

2003

International audience; Yersinia enterocolitica triggers activation of the nuclear factor (NF)-kappaB and production of the proinflammatory chemokine interleukin (IL)-8 in intestinal epithelial cells. This activation is due to adhesion of the bacteria via their outer membrane protein invasin to the host cells. Using Clostridium difficile toxins that specifically inactivate small GTPases, and transfection of inhibitory proteins of the Rho-GTPases, we demonstrate that Rac1, but not Cdc42 or Rho, is required for activation of NF-kappaB by invasin. Invasin activated the mitogen activated protein kinases (MAPK) p38 and c-Jun N-terminal protein kinase (JNK) but not extracellular signal regulated …

Biological and Mechanical Characterization of the Random Positioning Machine (RPM) for Microgravity Simulations

2021

The rapid improvement of space technologies is leading to the continuous increase of space missions that will soon bring humans back to the Moon and, in the coming future, toward longer interplanetary missions such as the one to Mars. The idea of living in space is charming and fascinating; however, the space environment is a harsh place to host human life and exposes the crew to many physical challenges. The absence of gravity experienced in space affects many aspects of human biology and can be reproduced in vitro with the help of microgravity simulators. Simulated microgravity (s-μg) is applied in many fields of research, ranging from cell biology to physics, including cancer biology. In…

INSECTS AND SMALL MAMMALS TRENDS IN THE DIET OF THE BARN OWL (TYTO ALBA) IN A MEDITERRANEAN ISLAND (SICILY).

1992

Le associazioni tra microrganismi

2008

Le associazioni tra microrganismi rivestono un ruolo centrale nell’ecologia microbica, la branca della microbiologia che studia le interelazioni tra micror- ganismi, dei microrganismi con organismi eucarioti (protozoi, nematodi, piante e animali) e con le componenti abiotiche dell’ambiente. I microrgani- smi possono anche partecipare ad associazioni genetiche, quali coniugazione, trasduzione e trasformazione, in particolare i batteri sono frequentemente implicati in una serie di interazioni non genetiche con altri microrganismi oggetto di questo capitolo. Infatti, in qualsiasi habitat i microrganismi viva- no e si moltiplichino essi devono interagire con altri micro- e macrorganismi facendo…

Effect of aerobic exercise and low carbohydrate diet on pre-diabetic non-alcoholic fatty liver disease in postmenopausal women and middle aged men: s…

2014

Background. Pre-diabetes and non-alcoholic fatty liver disease (NAFLD) are associated with an unhealthy lifestyle and pose extremely high costs to the healthcare system. In this study, we aim to explore whether individualized aerobic exercise (AEx) and low carbohydrate diet (LCh) intervention affect hepatic fat content (HFC) in pre-diabetes via modification of gut microbiota composition and other post-interventional effects. Methods/design. A 6-month randomized intervention with 6-month follow-up is conducted from January 2013 to December 2015. The target sample size for intervention is 200 postmenopausal women and middle-aged men aged 50–65 year-old with pre-diabetes and NAFLD. The qualifi…

Enterobacter cloacae administration induces hepatic damage and subcutaneous fat accumulation in high-fat diet fed mice.

2018

Accumulating evidence indicates that gut microbiota plays a significant role in obesity, insulin resistance and associated liver disorders. Family Enterobacteriaceae and especially Enterobacter cloacae strain B29 have been previously linked to obesity and hepatic damage. The underlying mechanisms, however, remain unclear. Therefore, we comprehensively examined the effects of E. cloacae subsp. cloacae (ATCC® 13047™) administration on host metabolism of mice fed with high-fat diet (HFD). C57BL/6N mice were randomly divided into HFD control, chow control, and E. cloacae treatment groups. The E. cloacae treatment group received live bacterial cells in PBS intragastrically twice a week, every ot…

Valoración de los parámetros inflamatorios como factores de riesgo independiente para supervivencia en los pacientes con cáncer de pulmón no microcít…

2021

Antecedentes: El cáncer de pulmón sigue siendo la causa principal de muerte por cáncer en nuestro medio. En concreto, el cáncer de pulmón no microcítico (CPNM) supone un 80% de los casos y el pronóstico, incluso en enfermedad localmente avanzada sigue siendo pobre, con una supervivencia en torno al 20% en estadio III. Además, la enfermedad localmente avanzada supone un subgrupo heterogéneo, en el que las opciones terapéuticas y la evolución pueden ser muy dispares, y puede incluir tanto la cirugía, como el tratamiento con quimiorradioterapia (QRT), con o sin tratamiento de mantenimiento con inmunoterapia, y el tratamiento paliativo. En este escenario cobra especial importancia la búsqueda d…

Effect of cholesterol-lowering treatment with a 585 on plasma membrane function and liver electron microscope appearence in rats.

1990

Oxidative and nitrosative stress in the metastatic microenvironment.

2010

Metastases that are resistant to conventional therapies are the main cause of most cancer-related deaths in humans. Tumor cell heterogeneity, which associates with genomic and phenotypic instability, represents a major problem for cancer therapy. Additional factors, such as the attack of immune cells or organ-specific microenvironments, also influence metastatic cell behavior and the response to therapy. Interaction of cancer and endothelial cells in capillary beds, involving mechanical contact and transient adhesion, is a critical step in the initiation of metastasis. This interaction initiates a cascade of activation pathways that involves cytokines, growth factors, bioactive lipids and r…

TRATTAMENTO DI SEDIMENTI MARINI MEDIANTE REATTORI BIOSLURRY: ANALISI DI PROCESSO E CARATTERIZZAZIONE MICROBIOLOGICA

2020

I sedimenti, elementi essenziali e dinamici di tutti i sistemi acquatici, rappresentano un potenziale serbatoio di sostanze tossiche di origine antropogenica. In ambiente marino, essi costituiscono un comparto ambientale estremamente complesso, con modalità di formazione, caratteristiche chimico-fisiche, organismi viventi e tipi di contaminazione estremamente variabili. In particolare, gli idrocarburi di origine petrolifera (indicati globalmente con la misura dei TPH - Total Petroleum Hydrocarbon) inquinanti prioritari particolarmente diffusi nelle aree fortemente industrializzate, tendono a rimanere intrappolati nei sedimenti per lunghi periodi di tempo; ciò li rende una fonte permanente d…