Search results for " MIS"
showing 10 items of 1281 documents
Risk-reducing hysterectomy and bilateral salpingo-oophorectomy in female heterozygotes of pathogenic mismatch repair variants: a Prospective Lynch Sy…
2021
Abstract Purpose To determine impact of risk-reducing hysterectomy and bilateral salpingo-oophorectomy (BSO) on gynecological cancer incidence and death in heterozygotes of pathogenic MMR ( path_MMR ) variants. Methods The Prospective Lynch Syndrome Database was used to investigate the effects of gynecological risk-reducing surgery (RRS) at different ages. Results Risk-reducing hysterectomy at 25 years of age prevents endometrial cancer before 50 years in 15%, 18%, 13%, and 0% of path_MLH1 , path_MSH2 , path_MSH6 , and path_PMS2 heterozygotes and death in 2%, 2%, 1%, and 0%, respectively. Risk-reducing BSO at 25 years of age prevents ovarian cancer before 50 years in 6%, 11%, 2%, and 0% and…
The Role of Hydrophobic Mismatch on Transmembrane Helix Dimerization in Living Cells
2019
The sharedneoantigen landscape of MSI cancers reflects immunoediting during tumor evolution
2019
AbstractThe immune system can recognize and attack cancer cells, especially those with a high load of mutation-inducedneoantigens. Suchneoantigens are particularly abundant in DNA mismatch repair (MMR)-deficient, microsatellite-unstable (MSI) cancers. MMR deficiency leads to insertion/deletion (indel) mutations at coding microsatellites (cMS) and toneoantigen-inducing translational frameshifts. The abundance of mutationalneoantigens renders MSI cancers sensitive to immune checkpoint blockade. However, the neoantigen landscape of MMR-deficient cancers has not yet been systematically mapped. In the present study, we used a novel tool to monitorneoantigen-inducing indel mutations in MSI colore…
Vadītājs kā līderis komandas darba vecināšanai pirmsskolas izglītības iestādē
2022
Pirmsskolas izglītības iestādes vadītāja loma ir nodrošināt labvēlīgu emocionālo un fizisko vidi. Tā kā mūsdienu sabiedrībā aktuāls ir jautājums par veiksmīgu izglītības iestādi un tās vadīšanu, tad šī jautājuma aktualitāte noteica arī maģistra darba tēmas izvēli. Darba mērķis: izpētīt izglītības iestādes vadītāja kā līdera ietekmi uz komandas darba veicināšanu. Pētījuma metodes: 1.Teorētiskā: zinātniskās literatūras analīze; 2.Empīriskās: Pirmsskolas izglītības iestādes pedagogu anketēšana, datu statistiskā apstrāde un analīze, PII vadītāja intervija. Secinājumi: Vadītājs kā līderis ietekmē komandas darba veicināšanu, to vadītājs var panākt rūpīgi izvēloties vadības stilu, izvērtējot fakto…
El sujeto en Psicoterapia Cognitiva
2015
En este trabajo se reflexiona sobre el tipo de sujetos implícitos en psicoterapia cognitiva. El modelo cognitivo de Beck, al que podemos considerar como un modelo racionalista y modernista, ejemplificará estos sujetos. En primer lugar, debemos situar a la terapia cognitiva en un contexto histórico y relacionarla con un sujeto caracterizado por poseer racionalidad y la habilidad para observar y detectar cogniciones, emociones y conductas. Este trabajo desarrolla todo ello introduciendo tres tipos principales de sujetos. El primero es el sujeto introspectivo y consciente, que es capaz de observar lo que pasa en su interior, tiene acceso libre y es consciente de su mundo cognitivo. El segundo,…
Racial discourse in James Baldwin's Blues for Mister Charlie (1964) : drama and the hegemonic struggle
2012
An expression of concern on research during the Covid-19 pandemic
2020
An experimental search for a correlation between outdoor 222Rn concentration and 210Pb activity in air particulate samples
2018
This work was aimed to search for a correlation between outdoor 222Rn air concentration and 210Pb activity in particulate samples collected on a filter. The existence of a correlation could support the hypothesis that both 222Rn and its long-lived product 210Pb are embedded into the same air masses and undergo the same air transport phenomena. Lead-210 activity was determined by means of gamma ray spectrometric measurement carried out a few days after the sampling whereas 222Rn concentration was measured through a commercial monitor. Experimental tests allowed to obtain a weak correlation between 222Rn and 210Pb air concentration as a preliminary result due to high uncertainties of outdoor …
Alcuni aspetti protezionistici nell’impiego di composti di 223Ra nella terapia medico-nucleare ambulatoriale
2018
L’impiego di composti di 223Ra, essenzialmente nella terapia medico-nucleare ambulatoriale delle metastasi ossee da carcinoma prostatico, ha posto diverse questioni dal punto di vista radioprotezionistico. Infatti, pur essendo il radionuclide caratterizzato da una emissione prevalentemente alfa, è comunque presente in bassa percentuale una componente gamma, costituita da emissioni di diversa energia e intensità, facilmente rilevabile con un monitor di dose o con uno spettrometro gamma portatile. In questo lavoro sono prese in esame le attività svolte all’interno di un reparto di Medicina Nucleare in cui è esercitata l’attività di terapia ambulatoriale (preparazione dei composti, somministra…
Visual mismatch negativity (vMMN): A review and meta-analysis of studies in psychiatric and neurological disorders
2016
The visual mismatch negativity (vMMN) response is an event-related potential (ERP) component, which is automatically elicited by events that violate predictions based on prior events. VMMN experiments use visual stimulus repetition to induce predictions, and vMMN is obtained by subtracting the response to rare unpredicted stimuli from those to frequent stimuli. One increasingly popular interpretation of the mismatch response postulates that vMMN, similar to its auditory counterpart (aMMN), represents a prediction error response generated by cortical mechanisms forming probabilistic representations of sensory signals. Here we discuss the physiological and theoretical basis of vMMN and review…