Search results for " MODELLI"

A longitudinal person-centred view on perceived employability : The role of job insecurity

2013

The primary aim of the present 1-year longitudinal study among university employees (N = 1314) was to investigate individual development of perceived employability (PE) by utilizing a person-centred approach. Thus, we identified latent classes of PE across 1 year based on growth mixture modelling. In addition, the latent classes were characterized by perceived job insecurity and the type of employment contract and its changes over the 1-year time period. The results showed four latent classes of PE that differed in the level and the direction of mean-level changes over time. These latent classes were: (1) stable relatively high PE (n = 641); (2) unstable decreasing PE (n = 45); (3) unstable…

A longitudinal person-centred approach to the job demands-control model

2016

We used a longitudinal design and a person-centred methodology to test the strain and learning hypotheses of the job demands–control model among Finnish employees (n = 926), who were followed-up at three time points covering a period of 2 years (2008–2010). First, we identified longitudinal subgroups in demands and control across three measurement points. Second, we examined how these subgroups differed in strain (job exhaustion) and motivation-related outcomes (vigour at work, work–family enrichment). Growth mixture modelling revealed four subgroups: “stable high strain”, “stable low strain”, “increasing control”, and “decreasing control”. The stable high- and low-strain subgroups also dif…

Changes in goal-related affects: Decrease burnout during a group psychotherapy intervention.

2011

The study examined the role played by changes in employees' goal-related affects in decreasing burnout during a group intervention. 62 white-collar employees, suffering from severe burnout, were randomized into 10-month group intervention programmes consisting of 16 intensive 1-day sessions every second week. The participants appraised their work and interpersonal goals according to their positive and negative affects weekly for 54 weeks. During the pre- and postintervention and follow-up (6 months later) measurements, the participants filled out a burnout measurement. The results, analysed by multilevel modelling, showed that a decrease in the negative affects and an increase in the positi…

Work engagement-team performance relationship : shared job crafting as a moderator

2016

The aims of this study were twofold: first, to investigate whether both individual and team work engagement are associated with team members' perceived team performance, and, second, to explore whether shared job crafting within teams moderates the relationship between work engagement and team members' perceived team performance. Data were collected from 1,074 Finnish educational sector employees working in 102 teams. Multilevel analysis revealed that both individual and team work engagement were associated with high levels of perceived team performance. The association between work engagement (both individual and team) and perceived team performance, however, varied across teams. The varia…

A Statistical Model of Spine Shape and Material for Population-Oriented Biomechanical Simulation

2021

In population-oriented ergonomics product design and musculoskeletal kinetics analysis, digital spine models of different shape, pose and material property are in great demand. The purpose of this study was to construct a parameterized finite element spine model with adjustable spine shape and material property. We used statistical shape model approach to learn inter-subject shape variations from 65 CT images of training subjects. Second order polynomial regression was used to model the age-dependent changes in vertebral material property derived from spatially aligned CT images. Finally, a parametric spine generator was developed to create finite element instances of different shapes and m…

Ottimizzazione della gestione della rete di adduzione primaria di Acquedotto Pugliese S.p.A. tramite modelli di supporto alle decisioni: l'utilizzo d…

2014

Through Predictive Personalized Medicine.

2020

Neuroblastoma (NBM) is a deadly form of solid tumor mostly observed in the pediatric age. Although survival rates largely differ depending on host factors and tumor-related features, treatment for clinically aggressive forms of NBM remains challenging. Scientific advances are paving the way to improved and safer therapeutic protocols, and immunotherapy is quickly rising as a promising treatment that is potentially safer and complementary to traditionally adopted surgical procedures, chemotherapy and radiotherapy. Improving therapeutic outcomes requires new approaches to be explored and validated. In-silico predictive models based on analysis of a plethora of data have been proposed by Lomba…

Pharmacophore modelling as useful tool in the lead compounds identification and optimization

2012

The goal of computer-aided molecular design methods in modern medicinal chemistry is to reduce the overall cost and time associated to the discovery and development of a new drug by identifying the most promising candidates to focus the experimental efforts on. Very often, many drug discovery projects have reached already a well-advanced stage before detailed structural data on the protein target have become available. A possible consequence is that often, medicinal chemists develop novel compounds for a target using preliminary structure–activity information, together with the theoretical models of interactions. Only responses that are consistent with the working hypothesis contribute to a…

Frequency-specific network activity predicts bradykinesia severity in Parkinson’s disease

2021

Highlights • Parallel subnetworks are affected in bradykinesia. • The primary motor and the premotor cortex are common nodes with task-specificity. • Beta activity decreases, gamma activity increases with improvement of bradykinesia. • Subthalamic stimulation reduces beta, increases gamma power in ipsilateral cortex. • Subnetworks act with frequency-specific oscillations.

Palermo tra innesti e piante originarie

2019

Se vi è qualcosa di profondamente e visceralmente connaturato alla stessa dimensione esistenziale della città di Palermo, sin dalle sue molteplici e stratificate origini fenicio-puniche, questo è certamente il concetto di “innesto”. Ed in analogia con l’innesto agrario, cioè con la pratica del far concrescere in una pianta esistente una parte di un altro vegetale, al fine di rafforzare il primo soggetto ma modificandolo verso un genere diverso da quello iniziale, l’intera storia millenaria della città potrà essere riguardata come il frutto di continue, cicliche introduzioni di modelli architettonici e urbani esogeni, declinati rispetto alle contingenze culturali autoctone dei diversi esempi…