6533b7cffe1ef96bd12586b1

RESEARCH PRODUCT

Frequency-specific network activity predicts bradykinesia severity in Parkinson’s disease

Gábor FeketeLászló HalászLászló BognárGünther DeuschlMuthuraman MuthuramanMarcell PalotaiLoránd ErőssBorbála Jávor-durayAndrea KelemenNabin KoiralaGertrúd Tamás

subject

PPC posterior parietal cortexBradykinesiaParkinson's diseaseDeep brain stimulationCognitive Neurosciencemedicine.medical_treatmentComputer applications to medicine. Medical informaticsR858-859.7FT finger tappingHypokinesiaElectromyographyElectroencephalographyPS pronation-supinationGamma oscillationPremotor cortexCER cerebellumSubthalamic NucleusDeep brain stimulationmedicineHumansRadiology Nuclear Medicine and imagingRC346-429SMA supplementary motor cortexM1 primary motor cortexResting state fMRImedicine.diagnostic_testbusiness.industryRegular ArticleBeta oscillationmedicine.diseasehumanitiesnervous system diseasesParkinson diseaseHG hand graspingSubthalamic nucleusCross-Sectional Studiesmedicine.anatomical_structurePMC premotor cortexNeurologyDLPFC dorsolateral prefrontal cortexFinger tappingStrEM structural equation modellingNeurology. Diseases of the nervous systemNeurology (clinical)businessNeuroscienceSTN subthalamic nucleus

description

Highlights • Parallel subnetworks are affected in bradykinesia. • The primary motor and the premotor cortex are common nodes with task-specificity. • Beta activity decreases, gamma activity increases with improvement of bradykinesia. • Subthalamic stimulation reduces beta, increases gamma power in ipsilateral cortex. • Subnetworks act with frequency-specific oscillations.

yearjournalcountryeditionlanguage
2021-10-01NeuroImage: Clinical
https://doi.org/10.1016/j.nicl.2021.102857