Search results for " Macro"
showing 10 items of 522 documents
Synthesis of hydrophilic polymers in supercritical carbon dioxide in the presence of a siloxane-based macromonomer surfactant: Heterogeneous polymeri…
2003
Batch free radical polymerization of 1-vinyl-2-pyrrolidone (VP) in super- critical carbon dioxide (scCO2) was studied in the presence of a reactive polysiloxane surfactant (PDMS-mMA). Phase behavior investigation showed that when the initial concentration of the surface active macromonomer was higher than 2.5% w/w with respect to the monomer, the reaction mixture, in the absence of efficient stirring, was initially opaque to the visible light, and it slowly turned to an orange tint. Polymeriza- tion experiments carried out with surfactant concentration higher than the aforemen- tioned value proceeded with a fast kinetics, and led to the formation of spherical nanoparticles with almost quant…
Role of Myeloid-Epithelial-Reproductive Tyrosine Kinase and Macrophage Polarization in the Progression of Atherosclerotic Lesions Associated With Non…
2019
Recent lines of evidence highlight the involvement of myeloid-epithelial-reproductive tyrosine kinase (MerTK) in metabolic disease associated with liver damage. MerTK is mainly expressed in anti-inflammatory M2 macrophages where it mediates transcriptional changes including suppression of proinflammatory cytokines and enhancement of inflammatory repressors. MerTK is regulated by metabolic pathways through nuclear sensors including LXRs, PPARs, and RXRs, in response to apoptotic bodies or to other sources of cholesterol. Nonalcoholic fatty liver disease (NAFLD) is one of the most serious public health problems worldwide. It is a clinicopathological syndrome closely related to obesity, insuli…
Evaluando la evaluación continua
2013
El principal proposito de este trabajo es analizar el impacto que tienen las nuevas metodologias educativas sobre los resultados del aprendizaje. En el mismo se compara el efecto sobre las notas de la evaluacion tradicional, basada en una prueba final unicamente, con la evaluacion continua. Los datos utilizados para el estudio provienen de una encuesta realizada el dia del examen final. Al ser la encuesta no anonima se ha podido combinar esta informacion con las calificaciones. El principal resultado del analisis realizado es que los alumnos que han optado por el itinerario de evaluacion continua han obtenido una mejor calificacion y, por tanto, un mejor resultado del aprendizaje. Esta mej…
Versican and Tumor-Associated Macrophages Promotes Tumor Progression and Metastasis in Canine and Murine Models of Breast Carcinoma
2019
Versican and tumor-associated macrophages (TAMs) are involved in growth and metastases in several cancers. Here, we investigated the potential role of versican, a matrix proteoglycan, and its correlation with TAMs infiltrates in different stages of two different breast cancer models: spontaneous canine mammary gland carcinomas and the murine 4T1 breast cancer model. The stromal versican expression was correlated with TAMs accumulation in tumors with an advanced stage from spontaneous canine mammary carcinoma samples. Versican expression in mice, identified in late stages of tumor progression, was associated to a high number of peri-tumoral infiltrating TAMs. Indeed, TAMs were related to a p…
Loss of histone macroH2A1 in hepatocellular carcinoma cells promotes paracrine-mediated chemoresistance and CD4+CD25+FoxP3+ regulatory T cells activa…
2020
Rationale: Loss of histone macroH2A1 induces appearance of cancer stem cells (CSCs)-like cells in hepatocellular carcinoma (HCC). How CSCs interact with the tumor microenvironment and the adaptive immune system is unclear. Methods: We screened aggressive human HCC for macroH2A1 and CD44 CSC marker expression. We also knocked down (KD) macroH2A1 in HCC cells, and performed integrated transcriptomic and secretomic analyses. Results: Human HCC showed low macroH2A1 and high CD44 expression compared to control tissues. MacroH2A1 KD CSC-like cells transferred paracrinally their chemoresistant properties to parental HCC cells. MacroH2A1 KD conditioned media transcriptionally reprogrammed parental …
Genetic ablation of macrohistone H2A1 leads to increased leanness, glucose tolerance and energy expenditure in mice fed a high-fat diet.
2015
Contains fulltext : 155347.pdf (Publisher’s version ) (Closed access) BACKGROUND/OBJECTIVES: In the context of obesity, epigenetic mechanisms regulate cell-specific chromatin plasticity, perpetuating gene expression responses to nutrient excess. MacroH2A1, a variant of histone H2A, emerged as a key chromatin regulator sensing small nutrients during cell proliferation and differentiation. Mice genetically ablated for macroH2A1 (knockout (KO)) do not show overt phenotypes under a standard diet. Our objective was to analyse the in vivo role of macroH2A1 in response to nutritional excess. METHODS: Twelve-week-old whole-body macroH2A1 KO male mice were given a high-fat diet (60% energy from lard…
Multiple morphological characters needed for field identification of cryptic long‐eared bat species around the Swiss Alps
2010
The identification of cryptic species may significantly change our view about their distribution, abundance, ecology and therefore conservation status. In the European Alps, molecular studies have revealed the existence of three sibling species of plecotine bats Plecotus auritus, Plecotus austriacus and, very recently, Plecotus macrobullaris. Knowledge of the ecological niche partitioning of cryptic species is a requisite to develop sound conservation policies. Yet, this requests the development of unambiguous identification methods easily applicable in the field. This study investigates the reliability of several morphological methods used for species recognition and proposes a new identif…
The invasion history of Elodea canadensis and E. nuttallii (Hydrocharitaceae) in Italy from herbarium accessions, field records and historical litera…
2022
AbstractWe analysed the invasion history of two North American macrophytes (Elodea canadensis and E. nuttallii) in Italy, through an accurate census of all available herbarium and field records, dating between 1850 and 2019, and a rich literature collection describing the initial introduction and naturalisation phase that supports the results obtained by the occurrence records. Elodea canadensis arrived in Italy before 1866 and had two invasion phases, between the 1890s and 1920s and between the 1990s and 2000s; E. nuttallii, probably arrived in the 1970s, started invading in 2000 and the invasion is still ongoing. Botanical gardens and fish farming played a crucial role in dispersal and na…
Isoëtes sabatina (Isoëtaceae, Lycopodiopsida). Taxonomic distinctness and preliminary ecological insights
2021
1) Isoëtes sabatina is the rarest aquatic quillwort in Europe. Although recently found (2013) in Lake Bracciano (central Italy), the species is just one step away from extinction with an estimated population not exceeding 400 individuals and a spatial range of a few hundred square metres. 2) Lake Bracciano is a deep, oligo-mesotrophic Mediterranean volcanic lake that has been subjected to human activities. From January to October 2017, the lake experienced a dramatic water level decrease (up to −1.50 m), which significantly affected the littoral zone and the habitat of I. sabatina. 3) To improve the chances of survival of I. sabatina, the first eco-taxonomic investigation on this species wa…
Macro-uncertainty and financial stress spillovers in the Eurozone
2020
Abstract This paper studies macro-uncertainty and financial distress spillovers within the Eurozone. We propose a novel methodology to derive the indices of spillovers, by using a Global Vector autoregressive model fitted to data sampled at mixed-frequencies. We find that macro-uncertainty and financial stress are relatively disconnected in the Eurozone. We also show that connectedness between core and periphery Eurozone countries mainly operates through financial stress and it decreases since the outbreak of the Eurozone sovereign debt crisis (with an increasing role played by peripheral countries). As a result, investors and policymakers should monitor separately macro-uncertainty and fin…