Search results for " Magnetic Resonance"

Women with borderline personality disorder do not show altered BOLD responses during response inhibition.

2015

Impulsivity is central to borderline personality disorder (BPD). Response inhibition, addressing the ability to suppress or stop actions, is one aspect of behavioral impulse control which is frequently used to assess impulsivity. BPD patients display deficits in response inhibition under stress condition or negative emotions. We assessed whether response inhibition and its neural underpinnings are impaired in BPD when tested in an emotionally neutral setting and when co-morbid attention-deficit/hyperactivity disorder (ADHD) is excluded. To this end, we studied response inhibition in unmedicated BPD patients and healthy controls (HC) in two independent samples using functional magnetic reson…

Serum magnesium and lipids: More clarity is needed

2007

Imaging of sarcopenia.

2016

Sarcopenia is currently considered a geriatric syndrome increasing in older people. The consequences of sarcopenia – in terms of impaired mobility, limited self-sufficiency and disability – have been amply demonstrated, increasing the need to develop methods to identify muscle mass loss as early as possible. Although sarcopenia involves a reduction in both muscle mass and function, loss of muscle mass remains the essential criterion for diagnosing this condition in daily practice. Computed tomography and magnetic resonance imaging represent the gold standard for studying body composition, and can identify quantitative and qualitative changes in muscle mass. These techniques are costly, time…

Brainstem reflex circuits revisited

2004

Our current understanding of brainstem reflex physiology comes chiefly from the classic anatomical-functional correlation studies that traced the central circuits underlying brainstem reflexes and establishing reflex abnormalities as markers for specific areas of lesion. These studies nevertheless had the disadvantage of deriving from post-mortem findings in only a few patients. We developed a voxel-based model of the human brainstem designed to import and normalize MRIs, select groups of patients with or without a given dysfunction, compare their MRIs statistically, and construct three-plane maps showing the statistical probability of lesion. Using this method, we studied 180 patients with…

Histaminanaloge, 27. Mitt. Bis (2,2′-histamine)

1985

Es wurden p-Phenylen-bis(2,2′-histamin) (6a), Ethylen-bis(2,2′-histamin) (6b), Tetramethylen-bis(2,2′-histamin) (6c) und Hexamethylen-bis(2,2′-histamin) (6d) dargestellt und auf Histamin-H1-und H2-agonistische Aktivitat untersucht. Histamine Analogues, XXVII: Bis(2,2′-histamines) p-Phenylenebis(2,2′-histamine) (6a), ethylenebis(2,2′-histamine) (6b), tetramethylenebis(2,2′-histamine) (6c), and hexamethylenebis(2,2′-histamine) (6d) were prepared and tested for histamine H1,-and H2-agonistic activity.

The first sorbicillinoid alkaloids, the antileukemic sorbicillactones A and B, from a sponge-derived Penicillium chrysogenum strain

2005

The saltwater culture of a Penicillium chrysogenum strain isolated from the Mediterranean sponge Ircinia fasciculata yielded three new sorbicillin-derived compounds (1-3), whose structures were elucidated mainly by 2D NMR and mass spectrometry. Among them, sorbicillactones A (1) and B (2) are the first sorbicillinoid natural products that contain nitrogen. Compound 1 is anti-HIV active and it exhibits a strong cytotoxic activity against L5178y leukemic cells, combined with a relatively low toxicity to cervical carcinoma HeLa S3 cells and pheochromocytoma PC 12 cells. The absolute configurations of I and 2 were elucidated by quantum chemical calculation of circular dichroism (CD) spectra. An…

ALANINE/ESR DOSIMETRY FOR TOTAL BODY IRRADIATION USING AN ANTHROPOMORPHIC PHANTOM

2016

Introduction: Total Body Irradiation (TBI) is a technique widely used in the radiation blood-oncology in the treatment of patients that need bone marrow transplantation or peripheral stem cell transplantation. This technique has some limitations such as the lack of homogeneity of the dose distribution (which may show variations of 20% in the different areas), irradiation of critical organs such as the lungs, the liver, the intestine and the eye-lens which can receive a dose comparable to that nominal and require appropriate shielding and a proper evaluation of the dose absorbed by them. The positive outcome of this type of radiation therapy is strictly related to a precise and accurate meas…

Anomalous temperature dependence of the IR spectrum of polyalanine

1997

Abstract We have studied the temperature dependence of the infrared spectra of acetanilide (ACN), tryptophan–(alanine) 15 , and tyrosine–(alanine) 15 . No sidebands of the amide-I vibration were observed in the polypeptides, but two anomalous sidebands of the NH stretch with a similar temperature dependence as that of the anomalous amide-I vibrational mode at 1650 cm −1 of crystalline ACN were detected. Fermi resonance combined with the appearance of a red-shifted sideband of NH stretch through coupling to lattice modes seems to explain this band structure. Observations are indicative of excitons that may occur in polypeptides as well as in single crystals of ACN.

Pitfalls to be considered on the metabolomic analysis of biological samples by HR-MAS

2014

HR-MAS (High-Resolution Magic AngleSpinning) is considered a powerfultechnique for metabolomic studies ofbiological samples that provides “intact”tissue spectra (Cheng et al., 1998; Waterset al., 2000; Sitter et al., 2002; Martinez-Bisbal et al., 2004; Payne et al., 2006;Coen et al., 2007; Bathen et al., 2010).The performance of HR-MAS, fol-lowed by quantitative histopathology hasdemonstrated that, despite some changes,HR-MAS can preserve approximately thetissue histopathologic features producingwell-resolved spectra of cellular metabo-lites (Cheng et al., 2000). Nevertheless,therearesomeaspectsarousedintheliter-ature about the possible biochemical andstructural changes that can occur durin…

Synthesis, characterization of diorganotin(IV) complexes of N-(2-hydroxyarylidene)aminoacetic acid and antitumour screening in vivo in ehrlich ascite…

2001

Some new diorganotin(IV) complexes have been prepared by reacting potassium N-(2-hydroxyarylidene)aminoacetate with R2SnCl2(R = Me,nBu,Ph). The complexes have been characterized by 1H,13C,119Sn NMR, IR and 119mSn Mössbauer spectroscopic techniques in combination with elemental analysis. In the solid state, the complexes possess penta- and hexa-coordinated tin centres. The hexa-coordinated tin complexes were found to dissociate in solution, giving rise to penta-coordinated species as revealed by 119Sn NMR spectroscopy. Antitumour screening in vivo of the complexes L4snPh2,L4SnPh2· Ph3SnCl and L4SntBU2·t Bu2SnCl2 (L4 = N-(2-hydroxyacetophenone)aminoacetate) is also reported. Copyright © 2001 …