6533b870fe1ef96bd12cf05d

RESEARCH PRODUCT

Histaminanaloge, 27. Mitt. Bis (2,2′-histamine)

Walter SchunackRobert Steffens

subject

Agonistchemistry.chemical_compoundmedicine.drug_classStereochemistryChemistryDrug DiscoverymedicinePharmaceutical ScienceBiological activityNuclear magnetic resonance spectroscopyHistamine

description

Es wurden p-Phenylen-bis(2,2′-histamin) (6a), Ethylen-bis(2,2′-histamin) (6b), Tetramethylen-bis(2,2′-histamin) (6c) und Hexamethylen-bis(2,2′-histamin) (6d) dargestellt und auf Histamin-H1-und H2-agonistische Aktivitat untersucht. Histamine Analogues, XXVII: Bis(2,2′-histamines) p-Phenylenebis(2,2′-histamine) (6a), ethylenebis(2,2′-histamine) (6b), tetramethylenebis(2,2′-histamine) (6c), and hexamethylenebis(2,2′-histamine) (6d) were prepared and tested for histamine H1,-and H2-agonistic activity.

https://doi.org/10.1002/ardp.19853180703