Search results for " Maintenance"
showing 4 items of 214 documents
Pre-sleep arousal and sleep quality during the COVID-19 lockdown in Italy
2021
Abstract Objective The COVID-19 pandemic has strongly affected daily habits and psychological wellbeing, and many studies point to large modifications in several sleep and sleep-related domains. Nevertheless, pre-sleep arousal during the pandemic has been substantially overlooked. Since hyperarousal represents one of the main factors for the development and the perpetuation of chronic insomnia disorder, the assessment of variables associated with high levels of pre-sleep arousal during the pandemic is clinically relevant. The study aimed to assess the prevalence and predictors of perceived sleep quality and pre-sleep arousal in an Italian sample during the COVID-19 lockdown. Methods We used…
Fault-proneness of open source software: Exploring its relations to internal software quality and maintenance process
2013
The goal of this study is to explore how fault-proneness of open source software (OSS) could be explained in terms of internal quality attributes and maintenance process metrics. We reviewed earlier studies and performed a multiple case study of eight Java-based projects based on data available in the Source Forge repository. Overall, we studied 342 re- leases of those systems. As is usual, software quality was regarded as a set of internal and external quality attributes. A to- tal of 76 internal quality attributes were measured from the source code of the selected systems via the tool SoftCalc. Two external quality attributes contributing to fault-proneness were in turn obtained from the …
VERNACULAR ARCHITECTURE IN INSULAR ITALY: HERITAGE TO PRESERVE AND VALUE
2021
The Mediterranean civilisation, in its millenary history, has also expressed itself through particular artefacts that have strongly characterised the territory. Knowledge of the artefacts that "qualify" a territory, both in historical and material terms, is a necessary prerequisite for tackling the planning and management problems relating to their protection and conservation. The architecture of the "vernacular" is linked to domestic life, customs, the "dialects" of places and the essence of the Genius Loci. The building heritage of the islands surrounding Sicily features special building techniques and systems that exploit natural resources to generate original artefacts and extremely fun…
The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress.
2021
Summary: Chromatin organization plays a crucial role in tissue homeostasis. Heterochromatin relaxation and consequent unscheduled mobilization of transposable elements (TEs) are emerging as key contributors of aging and aging-related pathologies, including Alzheimer’s disease (AD) and cancer. However, the mechanisms governing heterochromatin maintenance or its relaxation in pathological conditions remain poorly understood. Here we show that PIN1, the only phosphorylation-specific cis/trans prolyl isomerase, whose loss is associated with premature aging and AD, is essential to preserve heterochromatin. We demonstrate that this PIN1 function is conserved from Drosophila to humans and prevents…