Search results for " Mapping"
showing 10 items of 1411 documents
Different conformations of nascent polypeptides during translocation across the ER membrane
2000
Abstract Background In eukaryotic cells, proteins are translocated across the ER membrane through a continuous ribosome-translocon channel. It is unclear to what extent proteins can fold already within the ribosome-translocon channel, and previous studies suggest that only a limited degree of folding (such as the formation of isolated α-helices) may be possible within the ribosome. Results We have previously shown that the conformation of nascent polypeptide chains in transit through the ribosome-translocon complex can be probed by measuring the number of residues required to span the distance between the ribosomal P-site and the lumenally disposed active site of the oligosaccharyl transfer…
Membrane-insertion fragments of Bcl-xL, Bax, and Bid.
2004
Apoptosis regulators of the Bcl-2 family associate with intracellular membranes from mitochondria and the endoplasmic reticulum, where they perform their function. The activity of these proteins is related to the release of apoptogenic factors, sequestered in the mitochondria, to the cytoplasm, probably through the formation of ion and/or protein transport channels. Most of these proteins contain a C-terminal putative transmembrane (TM) fragment and a pair of hydrophobic alpha helices (alpha5-alpha6) similar to the membrane insertion fragments of the ion-channel domain of diphtheria toxin and colicins. Here, we report on the membrane-insertion properties of different segments from antiapopt…
Rilievo ed elaborazione di dati laser acquisiti con sistemi MMS in un parco urbano
2013
Questo articolo riassume l'esperienza acquisita tra il 2012 e il 2013 dal Dipartimento di Ingegneria Civile, Ambientale, Aerospaziale e dei Materiali dell'Università degli Studi di Palermo per l'indagine integrata del Parco Ninni Cassarà a Palermo, Italia, e la successiva sperimentazione di metodi, strumenti e tecniche basate su ricerche in corso, per quanto riguarda l'acquisizione e l'elaborazione dei dati GNSS e laser Scanner. Il lavoro è stato affrontato al fine di selezionare le tecniche meno costose e veloci da applicare in fase di acquisizione. Dopo la prima monumentazione di sedici punti di controllo distribuiti all'interno del sito e rilevati con ricevitori GNSS, la è stata pianific…
Artificial General Intelligence vs. Industry 4.0 : Do They Need Each Other?
2022
Artificial Intelligence (AI) is known to be a driving force behind the Industry 4.0. Nowadays the current hype on development and industrial adoption of the AI systems is mostly associated with the deep learning, i.e., with the abilities of the AI to perform various specific cognitive activities better than humans do. However, what about the Artificial General Intelligence (AGI), associated with the generic ability of a machine to perform consciously any task that a human can? Do we have many samples of the AGI research adopted by Industry 4.0 and used for smart manufacturing? In this paper, we report the systematic mapping study regarding the AGI-related papers (published during the five-y…
Analyzing Protein-Protein Spatial-Temporal Dependencies from Image Sequences Using Fuzzy Temporal Random Sets
2008
Total Internal Reflection Fluorescence Microscopy (TIRFM) allows us to image fluorescenttagged proteins near the plasma membrane of living cells with high spatial-temporal resolution. Using TIRFM imaging of GFP-tagged clathrin endocytic proteins, areas of fluorescence are observed as overlapping spots of different sizes and durations. Standard procedures to measure protein-protein colocalization of dual labeled samples threshold the original graylevel images to segment areas covered by different proteins. This binary logic is not appropriate as it leaves a free tuning parameter which can influence the conclusions. Moreover, these procedures rely on simple statistical analysis based on corre…
Fine-mapping of the B-cell epitope domain at the N-terminus of the preS2 region of the hepatitis B surface antigen
2002
In this study, we report the exact localization and substitutional characterization of a B-cell epitope domain at the N-terminus of the preS2 region of the hepatitis B surface antigen. A set of deletion variants containing preS2 sequences of different length was generated on the basis of frCP as a carrier. It was found after Western blot analysis that three monoclonal antibodies (MAbs) (2-11B1, 3-11C2, HB.OT10) recognized the linear preS2 sequence within the amino acid (aa) stretch 3-WNSTTFHQTLQDP-13. The importance of each aa residue of the epitope was proved by comparison of antibody binding to alanine-substituted peptides in both free-peptide and Pepscan variants.
On the influence of using binary and distributed information for 2D hydraulic model calibration and uncertainty evaluation
2013
Floods are considered the most frequent natural disaster world-wide and may have serious socio economic impacts in a community. In order to accomplish flood risk mitigation, flood risk analysis and assessment are required to provide information on current or future flood hazard and risks. Hazard and risk maps involve different data, expertise and effort, depending also on the end-users. More or less advanced deterministic approaches can be used, but intuitively probabilistic approaches seem to be more correct and suited for modelling flood inundation given typical uncertainties. Two very important matters remain open for research: the calibration of hydraulic models (oriented towards the es…
$n$-harmonic coordinates and the regularity of conformal mappings
2014
This article studies the smoothness of conformal mappings between two Riemannian manifolds whose metric tensors have limited regularity. We show that any bi-Lipschitz conformal mapping or $1$-quasiregular mapping between two manifolds with $C^r$ metric tensors ($r > 1$) is a $C^{r+1}$ conformal (local) diffeomorphism. This result was proved in [12, 27, 33], but we give a new proof of this fact. The proof is based on $n$-harmonic coordinates, a generalization of the standard harmonic coordinates that is particularly suited to studying conformal mappings. We establish the existence of a $p$-harmonic coordinate system for $1 < p < \infty$ on any Riemannian manifold.
Comments on the paper "COINCIDENCE THEOREMS FOR SOME MULTIVALUED MAPPINGS" by B. E. RHOADES, S. L. SINGH AND CHITRA KULSHRESTHA
2011
The aim of this note is to point out an error in the proof of Theorem 1 in the paper entitled “Coincidence theorems for some multivalued mappings” by B. E. Rhoades, S. L. Singh and Chitra Kulshrestha [Internat. J. Math. & Math. Sci., 7 (1984), 429-434], and to indicate a way to repair it.
Assessment of the interpretability of data mining for the spatial modelling of water erosion using game theory
2021
Abstract This study undertook a comprehensive application of 15 data mining (DM) models, most of which have, thus far, not been commonly used in environmental sciences, to predict land susceptibility to water erosion hazard in the Kahorestan catchment, southern Iran. The DM models were BGLM, BGAM, Cforest, CITree, GAMS, LRSS, NCPQR, PLS, PLSGLM, QR, RLM, SGB, SVM, BCART and BTR. We identified 18 factors usually considered as key controls for water erosion, comprising 10 factors extracted from a digital elevation model (DEM), three indices extracted from Landsat 8 images, a sediment connectivity index (SCI) and three other intrinsic factors. Three indicators consisting of MAE, MBE, RMSE, and…