Search results for " Mapping"
showing 10 items of 1411 documents
Concurrent TMS-fMRI for causal network perturbation and proof of target engagement
2021
The experimental manipulation of neural activity by neurostimulation techniques overcomes the inherent limitations of correlative recordings, enabling the researcher to investigate causal brain-behavior relationships. But only when stimulation and recordings are combined, the direct impact of the stimulation on neural activity can be evaluated. In humans, this can be achieved non-invasively through the concurrent combination of transcranial magnetic stimulation (TMS) with functional magnetic resonance imaging (fMRI). Concurrent TMS-fMRI allows the assessment of the neurovascular responses evoked by TMS with excellent spatial resolution and full-brain coverage. This enables the functional ma…
Structure and evolution of the leucine plasmids carried by the endosymbiont (Buchnera aphidicola) from aphids of the family Aphididae.
1998
In all examined species of the family Aphididae, the bacterial endosymbiont Buchnera aphidicola carries a plasmid encoding the genes leuABCD (involved in leucine biosynthesis) along with repA1, repA2 and ORF1. The gene organisation of the leucine plasmids was conserved, except in Buchnera isolated from Pterocomma populeum, where ORF1 was located in a different position. An inverted repeat (LIR1) located between repA2 and leuA is found in all of the Buchnera leucine plasmids examined. The predicted secondary structure of the LIR1 transcript conforms to a long hairpin loop, suggesting an involvement in transcription termination or messenger stability. Phylogenetic reconstruction based on repA…
A region on human chromosome 4 (q35.1→qter) induces senescence in cell hybrids and is involved in cervical carcinogenesis
2005
Human papillomavirus (HPV) types 16 and 18 are known to play a major role in cervical carcinogenesis. Additional genetic alterations are required for the development and progression of cervical cancer. Previously, we showed that the introduction of an entire human chromosome 4 into HPV-immortalized cells by microcell-mediated chromosome transfer (MMCT) can induce senescence in cell hybrids. In the present study, we established eight new murine donor cell lines harboring different fragments of the human chromosome 4. These were tested for their ability to induce senescence by MMCT into HPV16-immortalized keratinocytes (HPK II) and cervical carcinoma cells (HeLa). By exclusion, we could ident…
Human kininogens interact with M protein, a bacterial surface protein and virulence determinant.
1995
Streptococcus pyogenes, the most significant streptococcal species in clinical medicine, expresses surface proteins with affinity for several human plasma proteins. Here we report that kininogens, the precursors to the vasoactive kinins, bind to the surface of S. pyogenes. M protein, a surface molecule and a major virulence factor-in these bacteria, occurs in > 80 different serotypes. Among 49 strains of S. pyogenes, all of different M serotypes, 41 bound radiolabelled kininogens, whereas 6 M protein-negative mutant strains showed no affinity. M protein of most serotypes bind fibrinogen, and among the 55 strains tested, binding of kininogens was closely correlated to fibrinogen bindi…
Design of an ICT Tool for Decision Making in Social and Health Policies
2015
The governance requires technical support regarding the complexity in deciding health policies to assist people who require long-term care. Long-term care policies require the use of ICT simulation tools that can provide policy makers with the option of going into a decision theatre and virtually knowing the consequences of different policies prior to finally determining the real policy to be adopted. In this sense, there is an absence of simulation tools for decision making about long-term care policies. In this chapter, the authors propose the foundations and guidelines of SSIMSOWELL, a new scalable, multiagent simulation tool that increases the prediction capacity of governance in the lo…
A geostatistical approach to map near-surface soil moisture through hyperspatial resolution thermal inertia.
2021
Thermal inertia has been applied to map soil water content exploiting remote sensing data in the short and long wave regions of the electromagnetic spectrum. Over the last years, optical and thermal cameras were sufficiently miniaturized to be loaded onboard of unmanned aerial systems (UASs), which provide unprecedented potentials to derive hyperspatial resolution thermal inertia for soil water content mapping. In this study, we apply a simplification of thermal inertia, the apparent thermal inertia (ATI), over pixels where underlying thermal inertia hypotheses are fulfilled (unshaded bare soil). Then, a kriging algorithm is used to spatialize the ATI to get a soil water content map. The pr…
Analyzing the impact of using the SRP (Simplified roughness parameterization) method on soil moisture retrieval over different regions of the globe
2015
International audience; This paper focuses on a new approach to account for soil roughness effects in the retrieval of soil moisture (SM) at L-band in the framework of the SMOS (Soil Moisture and Ocean Salinity) mission: the Simplified Roughness Parameterization (SRP). While the classical retrieval approach considers SM and τ nad (vegetation optical depth) as retrieved parameters, this approach is based on the retrieval of SM and the TR parameter combining τ nad and soil roughness (TR τ nad + Hr /2). Different roughness parameterizations were tested to find the best correlation (R), bias and unbiased RMSE (ubRMSE) when comparing homogeneous retrievals of SM and in situ SM measurements carri…
The stem rust resistance gene Rpg5 encodes a protein with nucleotide-binding-site, leucine-rich, and protein kinase domains
2008
We isolated the barley stem rust resistance genes Rpg5 and rpg4 by map-based cloning. These genes are colocalized on a 70-kb genomic region that was delimited by recombination. The Rpg5 gene consists of an unusual structure encoding three typical plant disease resistance protein domains: nucleotide-binding site, leucine-rich repeat, and serine threonine protein kinase. The predicted RPG5 protein has two putative transmembrane sites possibly involved in membrane binding. The gene is expressed at low but detectable levels. Posttranscriptional gene silencing using VIGS resulted in a compatible reaction with a normally incompatible stem rust pathogen. Allele sequencing also validated the candi…
Multicolor fate mapping of Langerhans cell homeostasis
2013
The adult epidermal Langerhans cell network is formed by adjacent proliferative units composed of dividing cells and their terminally differentiated daughter cells.
The Latomiae of Syracuse: A Geotechnical Mapping Through Rock Reflectivity
2014
The archeological site of the Latomia del Paradiso (Syracuse) is endangered by severe instability phenomena due to the shape of walls and underground excava-tion related with the poor mechanical characteristics of the weathered and wet rock. The failure of huge blocks from the ceiling of the underground areas and the detaching of rock "flakes" from the walls surface make the geotechnical zon-ing particularly complex. the zoning is based on the characteristics of the rock wall surface that, in first approximation, can be distinguished in regularized sur-faces because of mining , and in irregular surfaces characterized by fracture prop-agation. The elaboration of reflectivity values obtained …