Search results for " Matrix"
showing 10 items of 2053 documents
Impairing Otp homeodomain function in oral ectoderm cells affects skeletogenesis in sea urchin embryos
2003
AbstractIn the sea urchin embryo skeletogenesis is the result of a complex series of molecular and cellular events that coordinate the morphogenetic process. Past and recent evidence strongly indicate that skeletal initiation and growth are strictly dependent on signals emanating from the oral ectodermal wall. As previously suggested, Orthopedia (Otp), a homeodomain-containing transcription factor specifically expressed in a small subset of oral ectoderm cells, might be implicated in this signalling pathway. In this study, we utilize three different strategies to address the issue of whether Otp is an upstream regulator of sketelogenesis. We describe the effects of microinjection of Otp mor…
Model for T2K indication with maximalθ23and trimaximalθ12
2011
Recently T2K experiment gives hint in favor of large reactor angle ${\ensuremath{\theta}}_{13}$. Most of the models, with tribimaximal mixing at the leading order, can not reproduce such a large mixing angle since they predict typically corrections for the reactor angle of the order ${\ensuremath{\theta}}_{13}\ensuremath{\sim}{\ensuremath{\lambda}}_{C}^{2}$, where ${\ensuremath{\lambda}}_{C}\ensuremath{\sim}0.2$. In this paper, we discuss the possibility to achieve large ${\ensuremath{\theta}}_{13}$ within the T2K region with maximal atmospheric mixing angle, ${sin}^{2}{\ensuremath{\theta}}_{23}=1/2$, and trimaximal solar mixing angle, ${sin}^{2}{\ensuremath{\theta}}_{12}=1/3$, through th…
Fast Poisson solvers for graphics processing units
2013
Two block cyclic reduction linear system solvers are considered and implemented using the OpenCL framework. The topics of interest include a simplified scalar cyclic reduction tridiagonal system solver and the impact of increasing the radix-number of the algorithm. Both implementations are tested for the Poisson problem in two and three dimensions, using a Nvidia GTX 580 series GPU and double precision floating-point arithmetic. The numerical results indicate up to 6-fold speed increase in the case of the two-dimensional problems and up to 3- fold speed increase in the case of the three-dimensional problems when compared to equivalent CPU implementations run on a Intel Core i7 quad-core CPU…
MMP-10/stromelysin-2 promotes invasion of head and neck cancer.
2011
BackgroundPeriostin, IFN-induced transmembrane protein 1 (IFITM1) and Wingless-type MMTV integration site family, member 5B (Wnt-5b) were previously identified as the invasion promoted genes of head and neck squamous cell carcinoma (HNSCC) by comparing the gene expression profiles between parent and a highly invasive clone. We have previously reported that Periostin and IFITM1 promoted the invasion of HNSCC cells. Here we demonstrated that Wnt-5b overexpression promoted the invasion of HNSCC cells. Moreover, stromelysin-2 (matrix metalloproteinase-10; MMP-10) was identified as a common up-regulated gene among Periostin, IFITM1 and Wnt-5b overexpressing HNSCC cells by using microarray data s…
Hematologic malignancies: The exosome contribution in tumor progression
2020
Abstract The bone marrow, composed of cells, extracellular matrix, and soluble factors, such as cytokines, chemokines and signaling molecules, provides a favorable microenvironment for hematologic tumor progression and for the development of drug resistance. Recently, extracellular vesicles (EVs), released by tumor and surrounding cells, have emerged as important players within the bone marrow niche. Here we will discuss the current knowledge on the EV- mediated crosstalk between tumor and normal cells, in order to better understand how vesicles can contribute to tumor progression. Advances in the knowledge of the role of cell-derived EVs in tumor microenvironment highlight the possibility …
Ultrasonic phased array inspection of wire plus arc additive manufacture (WAAM) samples using conventional and total focusing method (TFM) imaging…
2018
In this study, three aluminium samples produced by wire + arc additive manufacture (WAAM) are inspected using ultrasonic phased array technology. Artificial defects are machined using a centre drill, ø3 mm, and electro-discharge machining (EDM), ø0.5-1 mm, in a cylindrical through hole topology. The sample was first inspected by a single element wheel probe mounted on a KUKA robot in order to investigate the feasibility of using a conventional ultrasonic transducer approach. Unfortunately, the wheel probe was found to be unsuitable for scanning of the WAAM specimens and ultrasonic phased arrays were employed next. The setup included 5 MHz and 10 MHz arrays (128 elements) in direct contact w…
New Insights into the Anterior Complex
2020
<b><i>Objective:</i></b> To introduce visualization of the germinal matrix (GM), external angle of the frontal horn, and periventricular white matter while evaluating the anterior complex (AC) during basic ultrasound assessment of the fetal brain. <b><i>Case Presentations:</i></b> This is a retrospective observational study of healthy women with singleton pregnancies, with no increased risk of fetal central nervous system anomalies, attending routine ultrasound screening at 20–32 weeks’ gestation. Seventeen cases are presented in which an abnormal aspect of the GM or external angle of the frontal horn or periventricular white matter on AC eval…
Reconstruction of Peritoneal-like Structure in Three-Dimensional Collagen Gel Matrix Culture
1997
The peritoneum is a serous membrane consisting of different kinds of cells and extracellular matrix components (ECM). The aim of the present study was to develop a three-dimensional (3D) in vitro culture system for possible investigation of pathological conditions of the peritoneum. Human omental mesothelial cells (MC) and endothelial cells from the umbilical vein (EC) were cultivated either on (MC) or in (EC) a preformed type I collagen matrix. In 3D culture mesothelial cells showed their phenotypical in vivo characteristics and the synthesis of a new basal membrane (BM). Endothelial cells developed vessel-like structures, produce a BM and express E-selectin after TNF-alpha stimulation. Th…
Deep conservation of bivalve nacre proteins highlighted by shell matrix proteomics of the Unionoida Elliptio complanata and Villosa lienosa.
2016
The formation of the molluscan shell nacre is regulated to a large extent by a matrix of extracellular macromolecules that are secreted by the shell-forming tissue, the mantle. This so-called ‘calcifying matrix’ is a complex mixture of proteins, glycoproteins and polysaccharides that is assembled and occluded within the mineral phase during the calcification process. Better molecular-level characterization of the substances that regulate nacre formation is still required. Notable advances in expressed tag sequencing of freshwater mussels, such as Elliptio complanata and Villosa lienosa , provide a pre-requisite to further characterize bivalve nacre proteins by a proteomic approach. In this…
Association of AUUUA-binding Protein with A + U-rich mRNA during nucleo-cytoplasmic transport
1992
Resealed nuclear envelope (NE) vesicles from rat liver containing entrapped exogenous RNA were used to study the effect of adenosine+uridine binding factor (AUBF), present in cytosolic cell extracts, on ATP-dependent transport of A+U-rich RNA (AU+RNA) and A+U-free RNA (AU-RNA) across the NE. This factor specifically binds to A+U-rich sequences present in the 3' untranslated regions of lymphokine and cytokine mRNAs, containing overlapping AUUUA boxes (granulocyte-macrophage colony stimulating factor, interleukin-3). Addition of AUBF to the extravesicular compartment markedly increased the efflux of the in vitro transcribed, capped and polyadenylated AU+ RNAs. Export of entrapped AU- control …