Search results for " Methods"
showing 10 items of 4102 documents
La valutazione dei drop-out terapeutici: verso un'integrazione dei dati quantitativi e qualitativi nell'analisi del cambiamento in psicoterapia
2012
Il presente studio ha l'obiettivo di valutare se l'utilizzo di un paradigma mixed methods (Dattilio et al., 2010) possa favorire la comprensione degli aspetti che possono essere associati ad un esito positivo o negativo (drop-out) di un trattamento. Sono stati selezionati 4 casi di psicoterapia psicodinamica individuale da un database di ricerca relativo a pazienti seguiti presso un servizio pubblico specialistico per il trattamento dei disturbi alimentare (DCA). Due casi hanno interrotto il trattamento entro 6 mesi dall'inizio, mentre altri due continuano il percorso terapeutico. Ai pazienti sono stati somministrati i seguenti strumenti: una batteria testologica al baseline, finalizzata a …
Magnētiskā šķidruma pilieni rotējošā laukā: teorija, eksperimenti un simulācijas
2022
Magnētiskā šķidruma pilieni ir reizē deformējami un ietekmējami ar ārējo magnētisko lauku, kas tos padara par interesantu materiālu, kas is atradis daudzus pielietojumus mikrofluīdikā. Šajā darbā tiek aplūkota šādu pilienu dinamika rotējošā magnētiskajā laukā. Pilieni tiek pētīti, izmantojot vairākas pieejas - teorētiski, eksperimentāli un izmantojot simulācijas. Kad rotējošais magnētiskais lauks lauks ir vājš un piliena deformācija ir maza, piliena kustība tiek aprēķināta analītiski. Konstatēts, ka piliena formas attīstību laikā regulē trīs nelineāru diferenciālvienādojumu sistēma. Mazo deformāciju tuvinājumā piliena uzvedību kvalitatīvi raksturo viens parametrs, kas ir proporcionāls kapil…
Microparticle preparation by a propylene carbonate emulsification-extraction method
2018
Abstract The use of various harmful organic solvents for microparticle formulations is still widespread. Here, an alternative low toxicity solvent (propylene carbonate; PC) is proposed for the preparation of poly(lactic-co-glycolic-acid) (PLGA) microparticles. Based on the classical emulsification-solvent extraction methodology, the use of PC offers the unique advantage of an additional solvent extraction step using hydrolytic solvent cleavage during microparticle preparation. Spherical, rough-surfaced microparticles were obtained with a volume median diameter range from 20 to 60 µm. The residual PC content has been identified to be the major factor for the solidification hindrance, leading…
3D-Printed Solid Dispersion Drug Products.
2019
With the well-known advantages of additive manufacturing methods such as three-dimensional (3D) printing in drug delivery, it is disappointing that only one product has been successful in achieving regulatory approval in the past few years. Further research and development is required in this area to introduce more 3D printed products into the market. Our study investigates the potential of fixed dose combination solid dispersion drug products generated via 3D printing. Two model drugs&mdash
Predictive factors for sustained virological response after treatment with pegylated interferon α-2a and ribavirin in patients infected with HCV geno…
2014
BackgroundPrevious trials have often defined genotype 2 and 3 patients as an "easy to treat" group and guidelines recommend similar management.AimsThe present study looks for differences between the two genotypes and analyzes predictive factors for SVR.MethodsProspective, community-based cohort study involving 421 physicians throughout Germany. The analysis includes 2,347 patients with untreated chronic HCV genotype 2 (n = 391) and 3 (n = 1,956) infection treated with PEG-IFN α-2a plus ribavirin between August 2007 and July 2012.ResultsWhen compared with genotype 2 patients, those with genotype 3 were younger, had a shorter duration of infection, lower values of total cholesterol, LDL chole…
Interpretation of Ocular Melanin Drug Binding Assays. Alternatives to the Model of Multiple Classes of Independent Sites
2016
Melanin has a high binding affinity for a wide range of drugs. The determination of the melanin binding capacity and its binding affinity are important, e.g., in the determination of the ocular drug distribution, the prediction of drug effects in the eye, and the trans-scleral drug delivery. The binding parameters estimated from a given data set vary significantly when using different isotherms or different nonlinear fitting methods. In this work, the commonly used bi-Langmuir isotherm, which assumes two classes of independent sites, is confronted with the Sips isotherm. Direct, log-log, and Scatchard plots are used, and the interpretation of the binding curves in the latter is critically a…
Observational Approach and Perspective
1983
Well you did not cover more than half of my planned talk! (laughter). Let me comment on interferometric techniques, in particular speckle imaging which you mentioned. Doing speckle imaging with the largest telescopes now available will not give you better than the theoretical resolving power of the telescope. With a 4m telescope that is about 30 marc sec in the visible. That happens to be the radius of the supergiant Betelguese. So you are not going to achieve much with speckle imaging on these stars. One technique which has not been adequately exploited is that of lunar occultation which can give much better angular resolution than speckle, of the order of 2-3 marc sec. By using suitably c…
Mode-superposition correction method for deterministic and stochastic analysis of structural systems
2001
The role played by the modal analysis in the framework of structural dynamics is fundamental from both deterministic and stochastic point of view. However the accuracy obtained by means of the classical modal analysis is not always satisfactory. Therefore it is clear the importance of methods able to correct the modal response in such a way to obtain the required accuracy. Many methods have been proposed in the last years but they are meaningful only when the forcing function is expressed by an analytical function. Moreover in stochastic analysis they fail for white noise excitation. In the paper a method able to give a very accurate response for both deterministic and stochastic input is p…
Massive evaluation and analysis of Poincar�� recurrences on grids of initial data: a tool to map chaotic diffusion
2020
We present a novel numerical method aimed to characterize global behaviour, in particular chaotic diffusion, in dynamical systems. It is based on an analysis of the Poincar\'e recurrence statistics on massive grids of initial data or values of parameters. We concentrate on Hamiltonian systems, featuring the method separately for the cases of bounded and non-bounded phase spaces. The embodiments of the method in each of the cases are specific. We compare the performances of the proposed Poincar\'e recurrence method (PRM) and the custom Lyapunov exponent (LE) methods and show that they expose the global dynamics almost identically. However, a major advantage of the new method over the known g…
E-Learning Experiences in La Ribera Health Department
2014
This paper shows how the training of health professionals is improving thanks to the use of new technologies, in particular e-learning. This type of technology is widely used in medical education and there are multiple research works that report its effective deployment by health professionals and students. However, there is a need to incorporate e-learning platforms and online methods in healthcare organizations through a systematic and rigorous approach what is proposed in the current work. This approach has been applied since 2009 in the context of La Ribera Health Department implementing a high number of e-learning experiences. The obtained outcomes reveal how useful have been these exp…