Search results for " Methods"
showing 10 items of 4102 documents
The Relationship between Gray Matter Quantitative MRI and Disability in Secondary Progressive Multiple Sclerosis
2016
Purpose: In secondary progressive Multiple Sclerosis (SPMS), global neurodegeneration as a driver of disability gains importance in comparison to focal inflammatory processes. However, clinical MRI does not visualize changes of tissue composition outside MS lesions. This quantitative MRI (qMRI) study investigated cortical and deep gray matter (GM) proton density (PD) values and T1 relaxation times to explore their potential to assess neuronal damage and its relationship to clinical disability in SPMS. Materials and Methods: 11 SPMS patients underwent quantitative T1 and PD mapping. Parameter values across the cerebral cortex and deep GM structures were compared with 11 healthy controls, and…
Two Enhancers Control Transcription of Drosophila muscleblind in the Embryonic Somatic Musculature and in the Central Nervous System
2014
The phylogenetically conserved family of Muscleblind proteins are RNA-binding factors involved in a variety of gene expression processes including alternative splicing regulation, RNA stability and subcellular localization, and miRNA biogenesis, which typically contribute to cell-type specific differentiation. In humans, sequestration of Muscleblind-like proteins MBNL1 and MBNL2 has been implicated in degenerative disorders, particularly expansion diseases such as myotonic dystrophy type 1 and 2. Drosophila muscleblind was previously shown to be expressed in embryonic somatic and visceral muscle subtypes, and in the central nervous system, and to depend on Mef2 for transcriptional activatio…
The effects of lasers on bond strength to ceramic materials: A systematic review and meta-analysis
2018
Lasers have recently been introduced as an alternative means of conditioning dental ceramic surfaces in order to enhance their adhesive strength to cements and other materials. The present systematic review and meta-analysis aimed to review and quantitatively analyze the available literature in order to determine which bond protocols and laser types are the most effective. A search was conducted in the Pubmed, Embase and Scopus databases for papers published up to April 2017. PRISMA guidelines for systematic review and meta-analysis were followed. Fifty-two papers were eligible for inclusion in the review. Twenty-five studies were synthesized quantitatively. Lasers were found to increase bo…
Effects of femtosecond laser and other surface treatments on the bond strength of metallic and ceramic orthodontic brackets to zirconia.
2017
Femtosecond laser has been proposed as a method for conditioning zirconia surfaces to boost bond strength. However, metallic or ceramic bracket bonding to femtosecond lasertreated zirconia surfaces has not been tested. This study compared the effects of four conditioning techniques, including femtosecond laser irradiation, on shear bond strength (SBS) of metallic and ceramic brackets to zirconia.Three hundred zirconia plates were divided into five groups: 1) control (C); 2) sandblasting (APA); 3) silica coating and silane (SC); 4) femtosecond laser (FS); 5) sandblasting followed by femtosecond laser (APA+SC). A thermal imaging camera measured temperature changes in the zirconia during irrad…
Scientometrics analysis of research activity and collaboration patterns in Chagas cardiomyopathy.
2018
Background Chagas cardiomyopathy is a serious and common complication of Chagas disease. Methods Through bibliometric and Social Network Analysis, we examined patterns of research on Chagas cardiomyopathy, identifying the main countries, authors, research clusters, and topics addressed; and measuring the contribution of different countries. Results We found 1932 documents on Chagas cardiomyopathy in the MEDLINE database. The most common document type was ‘journal article’, accounting for 79.6% of the total (n = 1538), followed by ‘review’ (n = 217, 11.2%). The number of published records increased from 156 in 1980–1984 to 311 in 2010–2014. Only 2.5% were clinical trials. Brazil and the USA …
Modeling Multi-label Recurrence in Data Streams
2019
Most of the existing data stream algorithms assume a single label as the target variable. However, in many applications, each observation is assigned to several labels with latent dependencies among them, which their target function may change over time. Classification of such non-stationary multi-label streaming data with the consideration of dependencies among labels and potential drifts is a challenging task. The few existing studies mostly cope with drifts implicitly, and all learn models on the original label space, which requires a lot of time and memory. None of them consider recurrent drifts in multi-label streams and particularly drifts and recurrences visible in a latent label spa…
On the Trustworthiness of Error-Correcting Codes
2007
The use of error-correcting codes protects data against accidental or intentional errors, but to what extent can a decoded message be trusted? To answer this question, one has to take the role of the receiver. First, the maximum number of errors Lambda acceptable for decoding is fixed. With the weight distribution, the probability of false decoding can be calculated, conditioned on such a Lambda-bounded strategy. This probability is a monotonously increasing function in the channel error probability p and in the maximum number of accepted errors Lambda. Therefore, pure error detection is more trustworthy than error correction. Moreover, for sufficiently small p, codes with the lexicographic…
Analog joint source-channel Multiple Description coding scheme over AWGN parallel channels
2011
We propose a low complexity analog joint source channel coding Multiple Description (MD) scheme for transmitting the symbols of a Gaussian source across a pair of independent AWGN channels. The outputs of these channels have each a separated receiver, whereas a third receiver has both outputs available. At the transmitter side, a pair of bandwidth-reduction analog mappings are used for joint source-channel coding. The presented scheme has the inherent advantage over digital MD schemes based on separation, that coding and decoding can be performed by using a single-letter (or symbol), a strategy that is very suitable for applications where latency originated by the digital compression and th…
Incomplete Charge Collection at Inter-Pixel Gap in Low- and High-Flux Cadmium Zinc Telluride Pixel Detectors.
2022
The success of cadmium zinc telluride (CZT) detectors in room-temperature spectroscopic X-ray imaging is now widely accepted. The most common CZT detectors are characterized by enhanced-charge transport properties of electrons, with mobility-lifetime products μeτe > 10−2 cm2/V and μhτh > 10−5 cm2/V. These materials, typically termed low-flux LF-CZT, are successfully used for thick electron-sensing detectors and in low-flux conditions. Recently, new CZT materials with hole mobility-lifetime product enhancements (μhτh > 10−4 cm2/V and μeτe > 10−3 cm2/V) have been fabricated for high-flux measurements (high-flux HF-CZT detectors).…
World Influence of Infectious Diseases from Wikipedia Network Analysis
2019
AbstractWe consider the network of 5 416 537 articles of English Wikipedia extracted in 2017. Using the recent reduced Google matrix (REGOMAX) method we construct the reduced network of 230 articles (nodes) of infectious diseases and 195 articles of world countries. This method generates the reduced directed network between all 425 nodes taking into account all direct and indirect links with pathways via the huge global network. PageRank and CheiRank algorithms are used to determine the most influential diseases with the top PageRank diseases being Tuberculosis, HIV/AIDS and Malaria. From the reduced Google matrix we determine the sensitivity of world countries to specific diseases integrat…