Search results for " Microglia"

showing 3 items of 13 documents

Intestinal ischemia/reperfusion promotes brain damage via microglia activation: can we do something now?

2012

MalePathologymedicine.medical_specialtycomplicationsetiologyBrain damageAnimals Brain Diseases; etiology Intestines; blood supply Ischemia; complications Male Memory Disorders; etiology Microglia; physiology Reperfusion Injury; complicationsCritical Care and Intensive Care MedicineIschemiamedicineAnimalsischemia reperfusion brain damageBrain DiseasesMemory DisordersMicrogliabusiness.industryIntestinal ischemiaSettore MED/27 - Neurochirurgiablood supplyIntestinesmedicine.anatomical_structureReperfusion InjuryphysiologyMicrogliamedicine.symptombusiness
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Identification of calcium sensing receptor (CaSR) mRNA-expressing cells in normal and injured rat brain

2009

Calcium sensing receptor (CaSR), isolated for the first time from bovine and human parathyroid, is a G-protein-coupled receptors that has been involved in diverse physiological functions. At present a complete in vivo work on the identification of CaSR mRNA-expressing cells in the adult brain lacks and this investigation was undertaken in order to acquire more information on cell type expressing CaSR mRNA in the rat brain and to analyse for the first time its expression in different experimental models of brain injury. The expression of CaSR mRNAs was found mainly in scattered cells throughout almost all the brain regions. A double labeling analysis showed a colocalization of CaSR mRNA expr…

Malemedicine.medical_specialtyTime FactorsCentral nervous systemHippocampusCell CountSettore BIO/11 - Biologia MolecolareBiologySettore BIO/09 - Fisiologiachemistry.chemical_compoundSeizuresInternal medicineSettore BIO/10 - BiochimicaCaSRmedicineAnimalsRNA MessengerRats WistarIbotenic AcidMolecular BiologyIn Situ HybridizationNeuronsKainic AcidGeneral NeuroscienceDentate gyrusBrainColocalizationImmunohistochemistryRatsOligodendrogliamedicine.anatomical_structureEndocrinologynervous systemchemistryBrain InjuriesNeurogliaNeurology (clinical)Pyramidal cellCaSR; BrainCalcium sensing receptor (CaSR) isolated for the first time from bovine and human parathyroid is a G-protein-coupled receptors that has been involved in diverse physiological functions. At present a complete in vivo work on the identification of CaSR mRNA-expressing cells in the adult brain lacks and this investigation was undertaken in order to acquire more information on cell type expressing CaSR mRNA in the rat brain and to analyse for the first time its expression in different experimental models of brain injury. The expression of CaSR mRNAs was found mainly in scattered cells throughout almost all the brain regions. A double labeling analysis showed a colocalization of CaSR mRNA expression in neurons and oligodendrocytes whereas it was not found expressed both in the microglia and in astrocytes. One week after kainate-induced seizure CaSR was found in the injured CA3 region of the hippocampus and very interestingly it was found up-regulated in the neurons of CA1-CA2 and dentate gyrus. Similarly 1 week following ibotenic acid injection in the hippocampus CaSR mRNA expression was increased in oligodendrocytes both in the lesioned area and in the contralateral CA1-CA3 pyramidal cell layers and dentate gyrus. One week after needle-induced mechanical lesion an increase of labeled cells expressing CaSR mRNA was observed along the needle track. In conclusion the present results contribute to extend available data on cell type-expressing CaSR in normal and injured brain and could spur to understand the role of CaSR in repairing processes of brain injury.Receptors Calcium-SensingIbotenic acidDevelopmental BiologyAstrocyte
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Nano-structured myelin: new nanovesicles for targeted delivery to white matter and microglia, from brain-to-brain

2021

Neurodegenerative diseases affect millions of people worldwide and the presence of various physiological barriers limits the accessibility to the brain and reduces the efficacy of various therapies. Moreover, new carriers having targeting properties to specific brain regions and cells are needed in order to improve therapies for the brain disorder treatment. In this study, for the first time, Myelin nanoVesicles (hereafter defined MyVes) from brain-extracted myelin were produced. The MyVes have an average diameter of 100–150 ​nm, negative zeta potential, spheroidal morphology, and contain lipids and the key proteins of the myelin sheath. Furthermore, they exhibit good cytocompatibility. The…

Medicine (General)QH301-705.5nanovesiclesbrain deliveryBiomedical EngineeringBioengineeringmicroglia cellsBiomaterialsWhite matterMyelinR5-920Full Length Articlemedicinewithe matterBiology (General)nanovesicles myelin nanovesicles brain delivery withe matter microglia cellsMolecular BiologyMicrogliaAverage diameterChemistryCell Biologymyelin nanovesiclesmedicine.anatomical_structureSettore CHIM/09 - Farmaceutico Tecnologico ApplicativoMyelin sheathNeuroscienceBiotechnologyMaterials Today Bio
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