6533b828fe1ef96bd1288edc
RESEARCH PRODUCT
Nano-structured myelin: new nanovesicles for targeted delivery to white matter and microglia, from brain-to-brain
Valentina Di LibertoGiorgia AdamoPatrizia CancemiPasquale Massimo PiconeAntonella BongiovanniValeria VetriVera MuccilliFabio Salvatore PalumboSara AnselmoGiovanna PitarresiGiuseppe SancataldoSalvatore FedericoAntonio ChavesValentina GiglioDomenico Nuzzosubject
Medicine (General)QH301-705.5nanovesiclesbrain deliveryBiomedical EngineeringBioengineeringmicroglia cellsBiomaterialsWhite matterMyelinR5-920Full Length Articlemedicinewithe matterBiology (General)nanovesicles myelin nanovesicles brain delivery withe matter microglia cellsMolecular BiologyMicrogliaAverage diameterChemistryCell Biologymyelin nanovesiclesmedicine.anatomical_structureSettore CHIM/09 - Farmaceutico Tecnologico ApplicativoMyelin sheathNeuroscienceBiotechnologydescription
Neurodegenerative diseases affect millions of people worldwide and the presence of various physiological barriers limits the accessibility to the brain and reduces the efficacy of various therapies. Moreover, new carriers having targeting properties to specific brain regions and cells are needed in order to improve therapies for the brain disorder treatment. In this study, for the first time, Myelin nanoVesicles (hereafter defined MyVes) from brain-extracted myelin were produced. The MyVes have an average diameter of 100–150 nm, negative zeta potential, spheroidal morphology, and contain lipids and the key proteins of the myelin sheath. Furthermore, they exhibit good cytocompatibility. The MyVes were able to target the white matter and interact mainly with the microglia cells. The preliminary results here presented allow us to suppose the employment of MyVes as potential carrier to target the white matter and microglia in order to counteract white matter microglia-related diseases.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-09-01 | Materials Today Bio |