Search results for " Middle"

showing 10 items of 1097 documents

Rapid left ventricular filling in untreated hypertensive subjects with or without left ventricular hypertrophy

1992

In this study, independent contribution of age, HR, BMI, casual and ambulatory blood pressure, LVM and LVEF in evaluating diastolic filling have been investigated in 34 never-treated hypertensive patients and in 15 healthy normotensive subjects. All the subjects were free from coronary artery disease, valvular disease, heart failure, renal disease and psychiatric problems. All the hypertensive subjects (never treated) were subgrouped according to presence or absence of LVH. The PFR decreased significantly and tPFR increased significantly in hypertensive patients in comparison with normotensive subjects and they did not change in the presence vs absence of LVH. The PFR was inversely correlat…

AdultMalePulmonary and Respiratory Medicinemedicine.medical_specialtyAmbulatory blood pressureSettore MED/09 - Medicina InternaDiastoleBlood PressureCritical Care and Intensive Care MedicineLeft ventricular hypertrophyVentricular Function LeftBlood Pressure Echocardiography Female Humans Hypertension/complications Hypertension/physiopathology* Hypertension/radionuclide imaging Hypertension/ultrasonography Hypertrophy Left Ventricular/complications Hypertrophy Left Ventricular/physiopathology* Hypertrophy Left Ventricular/radionuclide imaging Hypertrophy Left Ventricular/ultrasonography Male Middle Aged Radionuclide Angiography Ventricular Function Left*Coronary artery diseaseInternal medicinemedicineHumanscardiovascular diseasesRadionuclide AngiographyEjection fractionbusiness.industryMiddle Agedmedicine.diseaseSettore MED/11 - Malattie Dell'Apparato CardiovascolareMean blood pressureEchocardiographyHeart failureHypertensionCardiologyEnd-diastolic volumeFemaleHypertrophy Left VentricularCardiology and Cardiovascular Medicinebusiness
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Asthma control in severe asthmatics under treatment with omalizumab: A cross-sectional observational study in Italy

2015

Few data are available on the proportion of asthmatics achieving a good asthma control (according GINA guidelines) and on the level of airway inflammation during omalizumab treatment. The aim of this cross-sectional national observational study was to assess the level of control (according to GINA guidelines) achieved in a group of asthmatics on omalizumab treatment, and to characterize the factors that influence the lack of control. We studied 306 asthmatics under omalizumab treatment for a median of 32 months (range 4-120). The level of control according to GINA was good in 25.2%, partial in 47.1% and poor in 24.5% of patients (data were missing for the remaining 3.2%). Comparison between…

AdultMalePulmonary and Respiratory Medicinemedicine.medical_specialtyExacerbationCross-sectional studyOmalizumabOmalizumabComorbiditySettore MED/10 - Malattie Dell'Apparato RespiratorioExhaled nitric oxide; Exacerbations; Comorbidities; Asthma; Omalizumab; ControlSeverity of Illness IndexComorbiditiesExacerbationsExhaled nitric oxideInternal medicineSeverity of illnessControlMedicineAnti-Asthmatic AgentHumansPharmacology (medical)Anti-Asthmatic AgentsInflammation MediatorAsthmaRespiratory Function TestAgedCross-Sectional Studiebusiness.industryBiochemistry (medical)ExacerbationMiddle Agedmedicine.diseaseComorbidityAsthmaRespiratory Function TestsCross-Sectional StudiesItalyExhaled nitric oxidePhysical therapyObservational studyAsthma; Comorbidities; Control; Exacerbations; Exhaled nitric oxide; Omalizumab; Adult; Aged; Anti-Asthmatic Agents; Asthma; Comorbidity; Cross-Sectional Studies; Female; Humans; Inflammation Mediators; Italy; Male; Middle Aged; Omalizumab; Respiratory Function Tests; Severity of Illness Index; Pulmonary and Respiratory Medicine; Biochemistry (medical); Pharmacology (medical)FemaleComorbiditieInflammation Mediatorsbusinessmedicine.drugHuman
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Bloating is associated with worse quality of life, treatment satisfaction, and treatment responsiveness among patients with constipation-predominant …

2016

Background The management of bloating is unclear and its relationship with patients' well-being and treatment satisfaction independent of other abdominal symptoms is uncharacterized. We evaluated the association of bloating with patient-reported outcomes. Methods Thirty-nine centers for functional gastrointestinal disorders joined the laxative inadequate relief survey. We enrolled 2203 consecutive outpatients with functional constipation (FC) or constipation-predominant irritable bowel syndrome (IBS-C) in two cross-sectional waves. Both wave 1 and 2 included the SF-12, the patient assessment of constipation-symptoms (PAC-SYM), and the treatment satisfaction questionnaire for medication (TSQ…

AdultMaleQuality of lifemedicine.medical_specialtyConstipationCross-sectional studyPhysiologyBloating; Chronic constipation; Functional constipation; Irritable bowel syndrome; Patient-reported outcomes; Quality of life; Treatment satisfaction; Physiology; Endocrine and Autonomic Systems; GastroenterologyBloating; Chronic constipation; Functional constipation; Irritable bowel syndrome; Patient-reported outcomes; Quality of life; Treatment satisfaction; Adult; Constipation; Cross-Sectional Studies; Female; Flatulence; Humans; Irritable Bowel Syndrome; Male; Middle Aged; Prevalence; Quality of Life; Surveys and QuestionnairesEndocrine and Autonomic System03 medical and health sciences0302 clinical medicineBloatingQuality of lifeSurveys and QuestionnairesInternal medicinePrevalencemedicineFlatulenceHumansIrritable bowel syndromePatient-reported outcomeChronic constipationSettore MED/12 - GastroenterologiaPatient-reported outcomesTreatment satisfactionBloating; Chronic constipation; Functional constipation; Irritable bowel syndrome; Patient-reported outcomes; Quality of life; Treatment satisfaction; Adult; Constipation; Cross-Sectional Studies; Female; Flatulence; Humans; Irritable Bowel Syndrome; Male; Middle Aged; Prevalence; Quality of Life; Surveys and Questionnaires; Physiology; Endocrine and Autonomic Systems; GastroenterologyEndocrine and Autonomic Systemsbusiness.industryChronic constipationBloatingSettore MED/09 - MEDICINA INTERNAGastroenterologyMiddle Agedmedicine.diseaseIrritable bowel syndromeSettore MED/18 - Chirurgia GeneraleCross-Sectional StudiesTolerability030220 oncology & carcinogenesisPhysical therapyFunctional constipationFemale030211 gastroenterology & hepatologymedicine.symptombusinessConstipationFunctional constipation
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Therapy expectations and physical comorbidity affect quality of life in chronic hepatitis C virus infection.

2007

Summary.  Hepatitis C virus (HCV) infection is associated with a significant reduction of health related quality of life (QOL), the causes and mechanisms of which are still unknown. To explore whether treatment history could affect QOL, we examined patients with detectable HCV viraemia who had a different therapeutic background. Two hundred sixty-four consecutive subjects with chronic HCV infection and detectable viraemia were enrolled. Of these, 163 were untreated patients, 43 were relapsers, 58 were nonresponders (NR) to nonpegylated interferon (IFN) therapy. To assess QOL, three self-report instruments were employed: the Short Form-36 (SF-36), the Chronic Liver Disease Questionnaire (CLD…

AdultMaleQuestionnairesmedicine.medical_specialtyHealth StatusHepatitis C virusComorbidityAffect (psychology)Chronic liver diseasemedicine.disease_causeliver-specific quality of life nonresponse to treatment physical comorbidity quality of lifeWorld healthVirusQUALITY OF LIFEChronic hepatitisQuality of lifeSurveys and QuestionnairesVirologyInternal medicineHumansMedicineChronicAgedHepatologybusiness.industryHepatitis C ChronicMiddle Agedmedicine.diseaseHepatitis CComorbidityhumanitiesAdult Aged Comorbidity Female Health Status Hepatitis C; Chronic; drug therapy/virology Humans Interferons; therapeutic use Linear Models Male Middle Aged Quality of Life Questionnairesdrug therapy/virologyInfectious Diseasestherapeutic useHCVLinear ModelsPhysical therapyFemaleInterferonsbusiness
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Health-related quality of life in epilepsy: findings obtained with a new Italian instrument

2008

The aim of the present study was to evaluate the Epi-QoL, a new Italian-specific measure of health-related quality of life (HRQOL) for adults with epilepsy; the clinical variables that affected the HRQOL score were also assessed. The Epi-QoL is a 46-item self-administered questionnaire focusing on six domains: Physical Functioning, Cognitive Functioning, Emotional Well-Being, Social Functioning, Seizure Worry, and Medication Effects. Eight hundred fifteen patients recruited from 24 secondary and tertiary Italian centers for the care of epilepsy were assessed. The results supported the reliability and validity of the Epi-QoL as a measure of HRQOL. The variables that significantly affected HR…

AdultMaleQuestionnairesmedicine.medical_specialtymedia_common.quotation_subjectHealth StatusMEDLINEHRQOL epilepsy questionnairepsychologySeverity of Illness IndexBehavioral NeuroscienceEpilepsyQuality of life (healthcare)epidemiology/psychologySurveys and QuestionnairesSeverity of illnessMedicineHealth Status IndicatorsHumansCognitive skillPsychiatrymedia_commonHealth related quality of lifeEpilepsybusiness.industryAdult Epilepsy; epidemiology/psychology Female Health Status Health Status Indicators Humans Italy; epidemiology Male Middle Aged Quality of Life; psychology Questionnaires Severity of Illness IndexMiddle Agedmedicine.diseaseComorbidityhumanitiesSettore MED/26 - NEUROLOGIANeurologyItalyQuality of LifeepidemiologyFemaleNeurology (clinical)Worrybusiness
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Long-term outcome of patients with or without osseointegrated implants after resection of mandibular ameloblastoma and reconstruction with vasculariz…

2018

BACKGROUND: The optimal management after the resection of mandibular ameloblastoma has been very challenging to surgeons. The aim of this study is to evaluate the functional, aesthetic, and quality of life outcomes of patients who had a segmental mandibular resection and immediate reconstruction with or without osseointegrated implants. METHOD: Patients' demographics, tumor characteristics, treatment, and complications were retrieved. Patients were divided into two groups: dental rehabilitated vs. nondental rehabilitated depending on the placement of osseointegrated implants followed by an implanted-retained prosthesis. Functional outcomes and quality of life were assessed using the Perform…

AdultMaleRadical treatmentmedicine.medical_specialtyMandibular Ameloblastoma Radical treatment Segmental Resection Fibular flap Dental rehabilitation.AdolescentVisual Analog ScaleVisual analogue scalemedicine.medical_treatmentMandibular OsteotomyMandibular NeoplasmsMandibular AmeloblastomaDental rehabilitation; Fibular flap; Mandibular Ameloblastoma; Radical treatment; Segmental Resection; Adolescent; Adult; Aged; Ameloblastoma; Child; Female; Fibula; Humans; Male; Mandibular Neoplasms; Mandibular Osteotomy; Middle Aged; Osseointegration; Patient Satisfaction; Quality of Life; Surgical Flaps; Visual Analog Scale; Young Adult; Dental Implantation Endosseous; Dental Implants; Mandibular ReconstructionProsthesisOsseointegrationSurgical FlapsAmeloblastoma03 medical and health sciencesYoung Adult0302 clinical medicinePatient satisfactionQuality of lifeOsseointegrationMedicineHumansFibular flapChildAgedSegmental ResectionDental ImplantsPerformance statusbusiness.industryDental Implantation Endosseous030206 dentistryMiddle AgedSurgeryDental ImplantationMandibular NeoplasmsFibulaPatient Satisfaction030220 oncology & carcinogenesisQuality of LifeSurgeryFemaleSegmental resectionMandibular ReconstructionEndosseousbusinessDental rehabilitationJournal of plastic, reconstructiveaesthetic surgery : JPRAS
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Prevalence of peripheral artery disease by abnormal ankle-brachial index in atrial fibrillation: implications for risk and therapy.

2013

AdultMaleRegistrieRiskMiddle AgedPeripheral Arterial Diseaseatrial fibrillation; cardiovascular disease; peripheral vascular disease; Adult; Aged; Atrial Fibrillation; Female; Humans; Internal Medicine; Italy; Male; Middle Aged; Peripheral Arterial Disease; Prevalence; Registries; Risk; Societies Medical; Ankle Brachial Index; Cardiology and Cardiovascular MedicineItalycardiovascular diseaseperipheral vascular diseaseMedicalAtrial FibrillationInternal MedicinePrevalenceHumansFemaleAnkle Brachial IndexRegistriesSocietiesCardiology and Cardiovascular MedicineSocieties MedicalAgedHuman
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Clinical analysis following lumbar interspinous devices implant: where we are and where we go

2014

Objectives:We present our experience with patients treated with interspinous devices who are affected by neurogenic intermittent claudication (NIC) or lumbar disc herniation (LDH) where the interspinous system has been inserted following microdiscectomy.Study design:Retrospective study.Methods:This study included patients (n=100) with NIC secondary to lumbar spinal stenosis (group 1), and patients (n=100) with LDH (group 2) in whom the interspinous device has been implanted following radicular decompression in a period spanning 6 years. The latter have been compared with a homogenous group of patients (n=100) where no interspinous system has been implanted following microdiscectomy (group 3…

AdultMaleReoperationMicrosurgerymedicine.medical_specialtyTime FactorsVisual analogue scaleDecompressionlumbar interspinous devicesAdult Prostheses and Implants Aged Decompression Surgical Disability Evaluation Female Follow-Up Studies Intermittent Claudication Intervertebral Disc Displacement Humans Lumbar Vertebrae Microsurgery Minimally Invasive Surgical Procedures Middle Aged Male Retrospective Studies Pain Measurement Patient Satisfaction Surveys and Questionnaires Reoperation Recurrence Treatment Outcome Spinal StenosisDisability EvaluationSpinal StenosisLumbarRecurrenceSurveys and QuestionnairesmedicineHumansMinimally Invasive Surgical ProceduresAgedPain MeasurementRetrospective StudiesLumbar VertebraeSettore MED/27 - Neurochirurgiabusiness.industryLumbar spinal stenosisProstheses and ImplantsGeneral MedicineIntermittent ClaudicationMiddle AgedDecompression Surgicalmedicine.diseaseIntermittent claudicationOswestry Disability IndexSurgeryTreatment OutcomeNeurologyPatient SatisfactionFemaleNeurology (clinical)Implantmedicine.symptombusinessClaudicationIntervertebral Disc DisplacementFollow-Up StudiesSpinal Cord
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The impact of prior TURP on radical prostatectomy surgical margins: A multicenter analysis and members of the mirror study, LUNA foundation

2013

Objective: To analyze positive surgical margins (PSM) after radical prostatectomy (RP) in the overall population and in patients previously treated with transurethral resection of the prostate (TURP). Materials and Methods: 2,408 patients treated with RP for clinically localized prostate cancer (PCa) were consecutively enrolled in 135 departments. We correlated PSM rates and all preoperative, surgical and pathological features. We stratified the site of PSM as unique or multifocal. Moreover, we analyzed differences between 75 patients who had undergone previous TURP and the remaining 2,333 patients. Results: In the entire study population, we identified 702 patients with PSM (29%). Using un…

AdultMaleRiskPrognosiBiopsyUrologyUrinary BladderPositive surgical marginurologic and male genital diseasesAgedAged 80 and overProstatectomyProstate cancerfungiProstateTransurethral Resection of ProstateMiddle AgedProstate-Specific AntigenRadical prostatectomyTransurethral prostate resectionPositive surgical margins; Prostate cancer; Radical prostatectomy; Transurethral prostate resection; Adult; Aged; Aged 80 and over; Biopsy; Humans; Italy; Male; Middle Aged; Neoplasm Grading; Prognosis; Prostate; Prostate-Specific Antigen; Prostatectomy; Prostatic Neoplasms; Risk; Transurethral Resection of Prostate; Treatment Outcome; Urinary Bladder; UrologyTreatment OutcomeItalyProstatic NeoplasmNeoplasm GradingHuman
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Variability of reverse transcriptase and overlapping S gene in hepatitis B virus isolates from untreated and lamivudine-resistant chronic hepatitis B…

2009

Background The high degree of diversity of the hepatitis B virus (HBV) quasispecies in chronically infected individuals raises the possibility that HBV genetic variants favouring resistance to nucleoside/nucleotide analogues (NAs) might pre-exist to treatment. The aim of this study was to investigate the genetic variability of the entire HBV reverse transcriptase (RT) domain and of the overlapping S gene in a large series of untreated hepatitis B surface antigen carriers and in lamivudine (3TC)-resistant patients. Methods Sequencing analysis of the entire HBV RT domain of isolates from 100 untreated (treatment- naive group) and 59 3TC-resistant (3TC-resistant group) consecutive patients wit…

AdultMaleSettore MED/07 - Microbiologia E Microbiologia ClinicaHepatitis B virusAdult; Aged; Drug Resistance; Viral; Female; Genetic Variation; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B; Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; RNA-Directed DNA Polymerase; Reverse Transcriptase Inhibitors; Sequence Analysis; DNA; Treatment OutcomeDrug ResistanceViral quasispeciesmedicine.disease_causeVirusHepatitis B ChronicOrthohepadnavirusDrug Resistance ViralmedicineHumansPharmacology (medical)ViralChronicAgedPharmacologyHepatitis B virusSettore MED/12 - GastroenterologiaHepatitis B Surface AntigensbiologyReverse-transcriptase inhibitorLamivudineGenetic VariationRNA-Directed DNA PolymeraseSequence Analysis DNADNAMiddle Agedbiology.organism_classificationHepatitis BVirologyReverse transcriptaseInfectious DiseasesTreatment OutcomeHepadnaviridaeLamivudineMutationReverse Transcriptase InhibitorsHBV reverse transcriptase gene S lamivudine resistantFemaleSequence Analysismedicine.drug
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