6533b827fe1ef96bd12871bb
RESEARCH PRODUCT
Bloating is associated with worse quality of life, treatment satisfaction, and treatment responsiveness among patients with constipation-predominant irritable bowel syndrome and functional constipation
L. NeriP. IovinoDonato Francesco AltomareVito AnneseDanilo BadialiGuido BasiliscoGabrio BassottiEdda BattagliaGabriele BazzocchiMassimo BelliniEmanuele BendiaLuigi BeniniGiuseppe BiscagliaIvano BivianoRenato BocchiniSebastiano BonventreFabrizio BossaGiovanni BrandimarteRenato CannizzaroMichele CicalaLivio CipollettaVirgilio ClaraRosanna CogliandroGiulia ComandiniEnrico CorazziariSergio CrottaRosario CuomoLucia D'albaFrancesco De GiorgiMario Del PianoMichela Di FonzoFrancesco Di MarioMichele Di StefanoVittorio D'onofrioKostantinos EfthymakisPierluigi FioreManuela FortunaWalter FriesEleonora GaetaniFrancesca GaleazziAntonio GasbarriniAndrea GeccherleFrancesco GiangregorioLisa GirardiMario GrassiniMarzia GroppoGiovanni GuarnieriMassimiliano Lo CascioRoberto LolliFrancesco LuzzaGiampiero MacarriMaria MarinoStefania MiragliaSanto MonastraMaria Cristina NeriMatteo NeriRoberto Antonio NorisSilvia OrselliSandro PassarettiAlberto PaviottiPaolo PazziAlberto PilottoPiero PortincasaNunzio RanaldoPaolo RavelliFrancesca RogaiRenato SablichVincenzo SavarinoGiancarlo SpinziVincenzo StanghelliniLeonardo TammaroFrancesco TorresanPaolo Usai SattaC. Claudio Vallesubject
AdultMaleQuality of lifemedicine.medical_specialtyConstipationCross-sectional studyPhysiologyBloating; Chronic constipation; Functional constipation; Irritable bowel syndrome; Patient-reported outcomes; Quality of life; Treatment satisfaction; Physiology; Endocrine and Autonomic Systems; GastroenterologyBloating; Chronic constipation; Functional constipation; Irritable bowel syndrome; Patient-reported outcomes; Quality of life; Treatment satisfaction; Adult; Constipation; Cross-Sectional Studies; Female; Flatulence; Humans; Irritable Bowel Syndrome; Male; Middle Aged; Prevalence; Quality of Life; Surveys and QuestionnairesEndocrine and Autonomic System03 medical and health sciences0302 clinical medicineBloatingQuality of lifeSurveys and QuestionnairesInternal medicinePrevalencemedicineFlatulenceHumansIrritable bowel syndromePatient-reported outcomeChronic constipationSettore MED/12 - GastroenterologiaPatient-reported outcomesTreatment satisfactionBloating; Chronic constipation; Functional constipation; Irritable bowel syndrome; Patient-reported outcomes; Quality of life; Treatment satisfaction; Adult; Constipation; Cross-Sectional Studies; Female; Flatulence; Humans; Irritable Bowel Syndrome; Male; Middle Aged; Prevalence; Quality of Life; Surveys and Questionnaires; Physiology; Endocrine and Autonomic Systems; GastroenterologyEndocrine and Autonomic Systemsbusiness.industryChronic constipationBloatingSettore MED/09 - MEDICINA INTERNAGastroenterologyMiddle Agedmedicine.diseaseIrritable bowel syndromeSettore MED/18 - Chirurgia GeneraleCross-Sectional StudiesTolerability030220 oncology & carcinogenesisPhysical therapyFunctional constipationFemale030211 gastroenterology & hepatologymedicine.symptombusinessConstipationFunctional constipationdescription
Background The management of bloating is unclear and its relationship with patients' well-being and treatment satisfaction independent of other abdominal symptoms is uncharacterized. We evaluated the association of bloating with patient-reported outcomes. Methods Thirty-nine centers for functional gastrointestinal disorders joined the laxative inadequate relief survey. We enrolled 2203 consecutive outpatients with functional constipation (FC) or constipation-predominant irritable bowel syndrome (IBS-C) in two cross-sectional waves. Both wave 1 and 2 included the SF-12, the patient assessment of constipation-symptoms (PAC-SYM), and the treatment satisfaction questionnaire for medication (TSQM-2). Wave 2 only included a global rating of change (GRC) scale to assess patients' assessment of efficacy concerning treatment switches occurred in the 3 months prior to the interview. Bloating in the abdomen was defined on the basis of PAC-SYM item 3. Key Results The average age was 50.1 years (SD, 16.7) and 82.1% of patients were women. The prevalence of bloating was 91.6% (n = 1970). Bloating was associated with SF-12 Physical Composite Score (p < 0.01), SF-12 Mental Composite Score (p < 0.01), GRC (p < 0.01), Satisfaction with treatment effectiveness (p < 0.01), convenience of administration (p < 0.01), and side effects (p < 0.01) after adjustment for possible confounders. Conclusions & Inferences Our data suggest that patients regard bloating as a key element in assessing clinical changes and treatments' efficacy as this symptom exerts a strong influence on patient-reported outcomes independent of possible confounders and other symptoms of constipation. Our data provide the rationale to investigate the efficacy and tolerability of new treatments specifically addressing this important, yet disregarded, patients' complain.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-01-01 |