0000000000621077

AUTHOR

Rosario Cuomo

showing 6 related works from this author

Confirmatory factor analysis of the Patient Assessment of Constipation-Symptoms (PAC-SYM) among patients with chronic constipation.

2015

Background and aim: PAC-SYM is widely adopted to asses constipation severity. However, it has been validated in a small sample, few items have been included based on expert opinion and not on empirical grounds, and its factor structure has never been replicated. We aimed at evaluating the psychometric properties of PAC-SYM in patients with chronic constipation. Methods: We enrolled 2,203 outpatients with chronic constipation in two waves. We used wave I sample to test the psychometric properties of the PAC-SYM and wave II sample to cross-validate its factor structure, to assess criterion validity, responsiveness to clinical change, and its minimal clinically important difference. Results: O…

AdultMalemedicine.medical_specialtyAbdominal painConstipationConstipation severityChronic constipation; Chronic non-organic constipation; Constipation severity; Quality of life; Adult; Chronic Disease; Constipation; Female; Humans; Male; Middle Aged; Patient Care; Quality of Life; Reproducibility of Results; Surveys and Questionnaires; Factor Analysis Statistical; Public Health Environmental and Occupational Health; Medicine (all)Reproducibility of ResultChronic constipation; Chronic non-organic constipation; Constipation severity; Quality of life; Adult; Chronic Disease; Constipation; Female; Humans; Male; Middle Aged; Patient Care; Quality of Life; Reproducibility of Results; Surveys and Questionnaires; Factor Analysis Statistical; Public Health Environmental and Occupational HealthQuality of lifeInternal medicineSurveys and QuestionnairesmedicineCriterion validitySurveys and QuestionnaireHumansChronic constipationSettore MED/12 - Gastroenterologiabusiness.industryChronic constipationMinimal clinically important differenceMedicine (all)Environmental and Occupational HealthSettore MED/09 - MEDICINA INTERNAPublic Health Environmental and Occupational HealthReproducibility of ResultsStatisticalMiddle Agedmedicine.diseaseConfirmatory factor analysisSettore MED/18 - Chirurgia GeneraleChronic DiseasePhysical therapyQuality of LifeFunctional constipationChronic constipation; Chronic non-organic constipation; Constipation severity; Quality of life; Public Health Environmental and Occupational HealthChronic constipation; Chronic non-organic constipation; Constipation severity; Quality of life; Adult; Chronic Disease; Constipation; Female; Humans; Male; Middle Aged; Patient Care; Quality of Life; Reproducibility of Results; Surveys and Questionnaires; Factor Analysis StatisticalFemalePublic HealthChronic non-organic constipationPatient Caremedicine.symptombusinessFactor Analysis StatisticalFactor AnalysisConstipationHumanQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation
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Common variants in the HLA-DQ region confer susceptibility to idiopathic achalasia

2014

Idiopathic achalasia is characterized by a failure of the lower esophageal sphincter to relax due to a loss of neurons in the myenteric plexus(1,2). This ultimately leads to massive dilatation and an irreversibly impaired megaesophagus. We performed a genetic association study in 1,068 achalasia cases and 4,242 controls and fine-mapped a strong MHC association signal by imputing classical HLA haplotypes and amino acid polymorphisms. An eight-residue insertion at position 227-234 in the cytoplasmic tail of HLA-DQ beta 1 (encoded by HLA-DQB1*05:03 and HLA-DQB1*06:01) confers the strongest risk for achalasia (P = 1.73 x 10(-19)). In addition, two amino acid substitutions in the. extracellular …

MaleModels MolecularAchalasiaImmunogeneticsBiologyMajor histocompatibility complexPolymorphism Single Nucleotidedigestive systemHLA-DQ alpha-ChainsHLA-DQ AntigensHLA-DQotorhinolaryngologic diseasesGeneticsmedicineHLA-DQ beta-ChainsHumansGenetic Predisposition to DiseaseEsophagusAllelesGenetic Association StudiesGenetic associationGeneticsAchalasiaMotility disorderASSOCIATIONmedicine.diseasedigestive system diseasesEsophageal AchalasiaINSIGHTSLogistic Modelsmedicine.anatomical_structureAmino Acid SubstitutionHaplotypesCase-Control StudiesImmunologybiology.proteinFemaleIdiopathic achalasiageneticMHCNature Genetics
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Constipation severity is associated with productivity losses and healthcare utilization in patients with chronic constipation

2014

OBJECTIVE: We sought to evaluate the association between constipation severity, productivity losses and healthcare utilization in a national sample of Italian patients with chronic non-organic constipation (CC). METHODS: We enrolled 878 outpatients with CC. Clinical and demographic data were collected by physicians during clinical examinations. Patients completed a self-administered questionnaire (Patient Assessment of Constipation-Symptoms, PAC-SYM; Work Productivity and Activity Impairment; healthcare utilization, and Symptoms Checklist 90 Revised - Somatization Scale, SCL-90 R). RESULTS: Mean PAC-SYM score was 1.62 ± 0.69. Mean weekly sick time due to constipation was 2.7 ± 8.6 h and pro…

medicine.medical_specialtyConstipationChronic constipation; Cost-of-illness study; Direct cost; Functional constipation; Healthcare utilization; Indirect cost; Irritable bowel syndrome; Productivity loss; Oncology; Gastroenterologymacromolecular substancesIndirect costsdirect costMedicineIn patientIntensive care medicineProductivitycost-of-illness studyIrritable bowel syndromeirritable bowel syndromeChronic constipation; cost-of-illness study; direct cost; functional constipation; healthcare utilization; indirect cost; irritable bowel syndrome; productivity lossChronic constipationChronic constipationbusiness.industryGastroenterologyhealthcare utilizationfunctional constipationOriginal Articlesmedicine.diseaseproductivity lossOncologyHealthcare utilizationindirect costPhysical therapyFunctional constipationmedicine.symptombusinessUnited European Gastroenterology Journal
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The HLA-DQβ1 insertion is a strong achalasia risk factor and displays a geospatial north-south gradient among Europeans.

2016

Idiopathic achalasia is a severe motility disorder of the esophagus and is characterized by a failure of the lower esophageal sphincter to relax due to a loss of neurons in the myenteric plexus. Most recently, we identified an eight-amino-acid insertion in the cytoplasmic tail of HLA-DQβ1 as strong achalasia risk factor in a sample set from Central Europe, Italy and Spain. Here, we tested whether the HLA-DQβ1 insertion also confers achalasia risk in the Polish and Swedish population. We could replicate the initial findings and the insertion shows strong achalasia association in both samples (Poland P=1.84 × 10(-04), Sweden P=7.44 × 10(-05)). Combining all five European data sets - Central E…

0301 basic medicineMaleEuropean Continental Ancestry GroupShort ReportAchalasiaHuman leukocyte antigenWhite People03 medical and health sciences0302 clinical medicineSwedish populationGeneticGenetics esophageal achalasiaMutation RateGeneticsmedicineotorhinolaryngologic diseasesPrevalenceHLA-DQ beta-ChainsHumansIn patientEsophagusRisk factorGenetics (clinical)GeneticsHLA-DQ beta-ChainPolymorphism Geneticbusiness.industryEuropean populationmedicine.diseaseEsophageal AchalasiaEuropeMutagenesis Insertional030104 developmental biologymedicine.anatomical_structureAttributable risk030211 gastroenterology & hepatologyFemalebusinessHumanDemography
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Potential options to optimize therapy of gastroesophageal reflux disease with proton pump inhibitors.

2007

Proton pump inhibitors (PPIs) are antisecretory agents that are widely used in the short- and long-term management of gastroesophageal reflux disease (GERD) to relieve symptoms, heal esophagitis, and prevent complications, such as strictures and Barrett’s esophagus. The total healthcare costs of GERD are high, especially for maintenance treatment. Therefore, the choice of cost-effective therapeutic options is an ineluctable challenge for public health authorities, third-party payers, and patients. In some European Union countries, a recent trend of public health authorities is to promote the choice of less expensive PPIs, regardless of their antisecretory potency – this in spite of the evid…

medicine.medical_specialtybusiness.industryGastroenterologyRefluxAntisecretory agentsEsomeprazoleProton Pump InhibitorsDiseaseProton pump inhibitorGastroesophageal reflux diseasemedicine.diseaseGastroenterologydigestive system diseasesInternal medicineGERDmedicineGastroesophageal RefluxHumansbusinessEsophagitisTherapy optimizationRandomized Controlled Trials as TopicDigestion
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Bloating is associated with worse quality of life, treatment satisfaction, and treatment responsiveness among patients with constipation-predominant …

2016

Background The management of bloating is unclear and its relationship with patients' well-being and treatment satisfaction independent of other abdominal symptoms is uncharacterized. We evaluated the association of bloating with patient-reported outcomes. Methods Thirty-nine centers for functional gastrointestinal disorders joined the laxative inadequate relief survey. We enrolled 2203 consecutive outpatients with functional constipation (FC) or constipation-predominant irritable bowel syndrome (IBS-C) in two cross-sectional waves. Both wave 1 and 2 included the SF-12, the patient assessment of constipation-symptoms (PAC-SYM), and the treatment satisfaction questionnaire for medication (TSQ…

AdultMaleQuality of lifemedicine.medical_specialtyConstipationCross-sectional studyPhysiologyBloating; Chronic constipation; Functional constipation; Irritable bowel syndrome; Patient-reported outcomes; Quality of life; Treatment satisfaction; Physiology; Endocrine and Autonomic Systems; GastroenterologyBloating; Chronic constipation; Functional constipation; Irritable bowel syndrome; Patient-reported outcomes; Quality of life; Treatment satisfaction; Adult; Constipation; Cross-Sectional Studies; Female; Flatulence; Humans; Irritable Bowel Syndrome; Male; Middle Aged; Prevalence; Quality of Life; Surveys and QuestionnairesEndocrine and Autonomic System03 medical and health sciences0302 clinical medicineBloatingQuality of lifeSurveys and QuestionnairesInternal medicinePrevalencemedicineFlatulenceHumansIrritable bowel syndromePatient-reported outcomeChronic constipationSettore MED/12 - GastroenterologiaPatient-reported outcomesTreatment satisfactionBloating; Chronic constipation; Functional constipation; Irritable bowel syndrome; Patient-reported outcomes; Quality of life; Treatment satisfaction; Adult; Constipation; Cross-Sectional Studies; Female; Flatulence; Humans; Irritable Bowel Syndrome; Male; Middle Aged; Prevalence; Quality of Life; Surveys and Questionnaires; Physiology; Endocrine and Autonomic Systems; GastroenterologyEndocrine and Autonomic Systemsbusiness.industryChronic constipationBloatingSettore MED/09 - MEDICINA INTERNAGastroenterologyMiddle Agedmedicine.diseaseIrritable bowel syndromeSettore MED/18 - Chirurgia GeneraleCross-Sectional StudiesTolerability030220 oncology & carcinogenesisPhysical therapyFunctional constipationFemale030211 gastroenterology & hepatologymedicine.symptombusinessConstipationFunctional constipation
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