Search results for " Mito"

Sicilia terra del mito. Atti del Convegno nazionale di studi, Palermo 13-14 novembre 2004.

2005

Contributi su miti riguardanti la Sicilia in autori del del mondo greco-romano

The Norman myth in the artistic culture of Hapsburgs’ Sicily: identity construction and representation of power

2015

In Sicilia, nell’Ottocento, si assistette in architettura a un revival neonormanno che trovava in quel momento glorioso della storia isolana la legittimazione per rivendicazioni autonomiste mirate alla ricostituzione di un regno di Sicilia finalmente libero dal giogo borbonico e da Napoli. Tuttavia, un fenomeno culturale analogo si era già registrato nel corso del xvi secolo. Nel rinascimento siciliano, infatti, si guardò non soltanto al classicismo e alla Roma dei Cesari, ma anche all’eredità del medioevo normanno, nel tentativo forse di costruire un’identità per un’isola, come la Sicilia asburgica, non libera e melting pot di culture diverse. Il caso del mito normanno presenta, però, in s…

Sicilia anima mundi. Lugares, Figuras e imàgenes de la Isla-Mito

2006

RACCONTO PER IMMAGINI MITICHE DELL'iSOLA MITO e visita poetica dei luoghi più belli della Sicilia

Simboli e potere tra mito e storia

2007

Ceļš: Latvijas Universitātes Teoloģijas fakultātes teoloģisks, reliģijpētniecisks un kultūrvēsturisks izdevums, Nr.61

2011

The mitotic kinase Aurora-A promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα+ breast cancer cells

2013

In this study, we demonstrate that constitutive activation of Raf-1 oncogenic signaling induces stabilization and accumulation of Aurora-A mitotic kinase that ultimately drives the transition from an epithelial to a highly invasive mesenchymal phenotype in estrogen receptor α-positive (ERα(+)) breast cancer cells. The transition from an epithelial- to a mesenchymal-like phenotype was characterized by reduced expression of ERα, HER-2/Neu overexpression and loss of CD24 surface receptor (CD24(-/low)). Importantly, expression of key epithelial-to-mesenchymal transition (EMT) markers and upregulation of the stemness gene SOX2 was linked to acquisition of stem cell-like properties such as the ab…

Post-Transcriptional Regulation of Human Inducible Nitric-Oxide Synthase Expression by the Jun N-terminal Kinase

2007

Human inducible nitric-oxide synthase (iNOS) expression is regulated both at transcriptional and post-transcriptional levels. In the present study, the effect of Jun N-terminal kinase (JNK) on human iNOS expression was investigated. In A549/8 human alveolar epithelial cells, both the inhibition of JNK by a pharmacological inhibitor anthra[1,9-cd]pyrazol-6(2H)-one1,9-pyrazoloanthrone (SP600125) and small interfering RNA (siRNA)-mediated down-regulation of JNK led to a reduction of iNOS mRNA and protein expression. iNOS promoter activity was not affected by these treatments. Hence, JNK seems to regulate iNOS expression through post-transcriptional mechanisms by stabilizing iNOS mRNA. Our labo…

The Mitochondrial tRNASer(UCN) Gene: A Novel m.7484A>G Mutation Associated with Mitochondrial Encephalomyopathy and Literature Review

2023

Mitochondrial tRNASer(UCN) is considered a hot-spot for non-syndromic and aminoglycoside-induced hearing loss. However, many patients have been described with more extensive neurological diseases, mainly including epilepsy, myoclonus, ataxia, and myopathy. We describe a novel homoplasmic m.7484A>G mutation in the tRNASer(UCN) gene affecting the third base of the anticodon triplet in a girl with profound intellectual disability, spastic tetraplegia, sensorineural hearing loss, a clinical history of epilepsia partialis continua and vomiting, typical of MELAS syndrome, leading to a myoclonic epilepticus status, and myopathy with severe COX deficiency at muscle biopsy. The mutation was also …

Molecular phylogenetics and historical biogeography of the west-palearctic common toads (Bufo bufo species complex)

2012

In most pan-Eurasiatic species complexes, two phenomena have been traditionally considered key processes of their cladogenesis and biogeography. First, it is hypothesized that the origin and development of the Central Asian Deserts generated a biogeographic barrier that fragmented past continuous distributions in Eastern and Western domains. Second, Pleistocene glaciations have been proposed as the main process driving the regional diversification within each of these domains. The European common toad and its closest relatives provide an interesting opportunity to examine the relative contributions of these paleogeographic and paleoclimatic events to the phylogeny and biogeography of a wide…

Characterizing a hybrid zone between a cryptic species pair of freshwater snails.

2015

Characterizing hybrid zones and their dynamics is a central goal in evolutionary biology, but this is particularly challenging for morphologically cryptic species. The lack of conspicuous divergence between parental types means intermediate hybrid forms often go undetected. We aimed to detect and characterize a suspected hybrid zone between a pair of morphologically cryptic lineages of the freshwater snail, Radix. We sampled Radix from across a contact zone between two mitochondrial lineages (Radix balthica and an undescribed lineage termed 'MOTU3') and detected admixture between two nuclear genotype clusters, which were significantly but not categorically associated with the mitochondrial …