Search results for " Modeling"

Using a Multidimensional Measure of Resilience to Explain Life Satisfaction and Academic Achievement of Adults With Reading Difficulties.

2014

We assessed the impact of intrapersonal and interpersonal resilience, persistence, and number of difficulties in addition to reading problems on life satisfaction (general, social, and self) and academic achievement. A total of 120 adults with reading difficulties who either were completing a university degree or were recent graduates responded to an in-lab or online survey. Results indicated that intrapersonal resilience correlated positively with interpersonal resilience and persistence, and both resilience factors were negatively associated with number of difficulties. Using structural equation modeling, intrapersonal resilience explained general satisfaction, intrapersonal resilience a…

Predicting First-Year College Student Retention: Validation of the College Persistence Questionnaire in a Spanish Sample

2019

This paper analyzes the factorial and predictive validity of a Spanish adaptation of the College Persistence Questionnaire (SCPQ) on the retention of first year students (FYS) at university. The participants were 490 FYS from two public universities in Southern Europe (Spain). Factorial analysis of the SCPQ (&chi

Prospective study of sport dropout: A motivational analysis as a function of age and gender

2012

Abstract Introduction: This paper aimed to analyse the predictive ability of a self-determination theory (SDT) based model describing competitive sport dropout, and variance as a function of age and gender. Variables included in the model were: psychological need satisfaction, self-determined motivation, perceived conflict between sport and study, intention to practise sport, and dropout. Methods: A prospective study was performed over a period of 19 months. Variables considered as predictors of sport dropout were measured initially, and after 19 months persistence or dropout was assessed. The sample consisted of 857 athletes aged 11–19 (mean value 15.3; standard deviation = 1.77), 680 male…

A 3D reworking of the urban transformations of Palermo in recent history for a hypothesis of a "City Museum" based on digital visualizations

2021

The objective that drives this research is given by a multitude of information which, in addition to the contribution of technology, allows us to study, analyze, verify and remodel the sites, monuments and evolutions of the city through graphic processes of perspective restitution that start from the analysis of historical photos. The drawing methods, the digital graphic rendering and through the aid of geometric techniques, contribute to the reconstruction of projects and architectures that are now lost, this is possible thanks to the methods of perspective, axonometry and three-dimensional restitution. This remarkable photographic heritage belonging to Palermo, but also to any other city …

Trajectories of change in reading self-efficacy: A longitudinal analysis of self-efficacy and its sources

2021

The beliefs children hold about their capabilities as readers are known to influence their reading achievement. The aim of this study was to extend previous work by examining trajectories of change in reading self-efficacy among primary school students (N = 1327) and the relations between the trajectories of self-efficacy and their hypothesized sources over 11 months. Using growth mixture modeling, we identified four trajectories of change in reading self-efficacy, involving increasing, stable, and declining trends. These trajectories of change in reading self-efficacy were associated with students’ varying experiences with the four sources of self-efficacy over time. Higher levels of maste…

Isolated myocardiocytes and DNA synthesis: a possible experimental model to predict the in vivo cardiotoxicity

1989

3D-QSAR pharmacophore modeling and in silico screening of new Bcl-xl inhibitors.

2010

Bcl-2 proteins family members play several roles in tumoral proliferation: they inhibit proapoptotic activity during oncogenesis, support tumor cells survival, induce chemoresistance. The discovery of new small inhibitors of Bcl-xl represents a new frontier for cancer treatment. In this study, a 3D-QSAR pharmacophore model was developed, based on 42 biarylacylsulfonamides, and used to understand the structural factors affecting the inhibitory potency of these derivatives. Aromatic, negative charge, and hydrogen bond acceptor effects contribute to the inhibitory activity. The model was then employed as 3D search query to screen ZINC drug-like database in order to select new scaffolds. Finall…

1,2,4-Amino-triazine derivatives as pyruvate dehydrogenase kinase inhibitors: Synthesis and pharmacological evaluation

2023

: Among the different hallmarks of cancer, deregulation of cellular metabolism turned out to be an essential mechanism in promoting cancer resistance and progression. The pyruvate dehydrogenase kinases (PDKs) are well known as key regulators in cells metabolic process and their activity was found to be overexpressed in different metabolic alerted types of cancer, including the high aggressive pancreatic ductal adenocarcinoma (PDAC). To date few PDK inhibitors have been reported, and the different molecules developed are characterized by structural chemical diversity. In an attempt to find novel classes of potential PDK inhibitors, the molecular hybridization approach, which combine two or m…

Un’esperienza di rilevamento architettonico con tecniche integrate

2004

Lo studio esposto riguarda la sperimentazione sulle tecniche per il rilevamento e la rappresentazione di manufatti architettonici caratterizzati dalla presenza di una ricca decorazione scultorea. In particolare, è stata condotta una applicazione sulla parete di ingresso dell’Oratorio del SS. Rosario presso la chiesa di Santa Cita, nel centro storico di Palermo. Nel corso dello studio sono stati messi a confronto ed integrati i dati provenienti dal rilevamento diretto, topografico, fotogrammetrico, e da acquisizioni eseguite con laser a scansione. This paper is addressed to test suitable techniques for surveying and restitution of architectural surfaces decorated with free-form masses (i.e. …

Validation of a two-dimensional modeling of an externally irradiated slurry photoreactor

2015

Abstract A two-dimensional model describing the behavior of a batch cylindrical photoreactor has been validated through a series of photocatalytic reactivity runs. The light intensity radiation field produced by 1–6 external UV fluorescent lamps was modeled together with Langmuir–Hinshelwood kinetics and 4-nitrophenol (NP) and Degussa P25 TiO 2 were used as the probe molecule and the catalyst, respectively. The experiments were carried out under different conditions of light intensity, photocatalyst amount and substrate concentration. The model parameters were the kinetic constant of substrate adsorption, desorption and degradation and the exponent of the power law expressing the kinetics d…